Handedness in post-traumatic stress disorder: A meta-analysis

Borawski, Jette; Παπαδάτου-Παστού, Μαριέττα; Packheiser, Julian; Ocklenburg, Sebastian

doi:10.1016/j.neubiorev.2022.105009

Cited by 16 publications

(10 citation statements)

References 62 publications

(58 reference statements)

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“…Hence, one might speculate that it is not left- but mixed-handedness/-footedness that shows the closest association with clinical constructs. Indeed, this is in line with several meta-analyses suggesting that disorders such as PTSD 36 and schizophrenia 32 are related to mixed-handedness in particular, rather than left-handedness. Therefore, it has been put forward that a reduction or an absence of asymmetries (such as mixed-handedness) rather than a reversal (such as left-handedness) is of relevance for clinical outcomes 36 .…”

Section: Discussionsupporting

confidence: 89%

“…This assumption gains further plausibility considering the fact that clinical samples frequently produce large effects with respect to laterality measures. For instance, as already mentioned in the introduction, meta-analyses univocally confirm a certain relation between atypical handedness or other forms of functional lateralization and diverse clinical diagnoses (e.g., schizophrenia 31 , 32 , ASD 35 , PTSD 36 ). Therefore, one might conclude there is some sort of rubicon covering noticeable qualitative differences between healthy and clinical samples regarding asymmetry measures.…”

Section: Discussionmentioning

confidence: 68%

“…Amongst others, a heightened prevalence of non-right-handedness was found in schizophrenia 31 , 32 , dyslexia 33 , 34 , and autism spectrum disorder (ASD) 35 . Recent meta-analyses further confirmed this pattern for post-traumatic stress disorder (PTSD) 36 , but not for depression 37 . Still, for depression 38 as well as for schizophrenia 32 , 39 , 40 , and dyslexia 41 , 42 , studies have shown a higher frequency of atypical language lateralization.…”

Section: Introductionmentioning

confidence: 99%

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A deep phenotyping approach to assess the association of handedness, early life factors and mental health

Pfeifer,

Schmitz,

Schwalvenberg

et al. 2023

Sci Rep

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The development of handedness and other form of functional asymmetries is not yet understood in its critical determinants. Early life factors (e.g., birth weight, birth order) have been discussed to contribute to individual manifestations of functional asymmetries. However, large-scale data such as the UK Biobank suggest that the variance in handedness that is explained by early life factors is minimal. Additionally, atypical handedness has been linked to clinical outcomes such as neurodevelopmental and psychiatric disorders. Against the background of this triad, the current study investigated associations between different forms of functional asymmetries and (a) early life factors as well as (b) clinical outcomes. Functional asymmetries were determined by means of a deep phenotyping approach which notably extends previous work. In our final sample of N = 598 healthy participants, the different variables were tested for associations by means of linear regression models and group comparisons (i.e., ANOVAs and Chi-squared tests). Confirming previous findings from larger cohorts with shallow phenotyping, we found that birth factors do not explain a substantial amount of variance in functional asymmetries. Likewise, functional asymmetries did not seem to have comprehensive predictive power concerning clinical outcomes in our healthy participants. Future studies may further investigate postulated relations in healthy and clinical samples while acknowledging deep phenotyping of laterality.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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A deep phenotyping approach to assess the association of handedness, early life factors and mental health

Pfeifer,

Schmitz,

Schwalvenberg

et al. 2023

Sci Rep

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“…In the general population, around 80–90% of individuals are right-handers whereas the frequency of left-handedness lies between 9.3% (according to stringent criteria when assessing left-handedness) to 18.1% for the broader definition of non-right-handedness, i.e., individuals favoring the left hand or use both hands equally often (Papadatou-Pastou et al 2020 ). In line with the hypothesis that atypical hemispheric asymmetries are associated with atypical behavioral lateralization (i.e., higher prevalence of non-right-side bias), higher rates of non-right-handedness are found in several mental disorders such as attention deficit hyperactivity disorder (Nastou et al 2022 ), autism spectrum disorders (Markou et al 2017 ), post-traumatic stress disorder (Borawski et al 2022 ), and schizophrenia (Dragovic and Hammond 2005 ; Hirnstein and Hugdahl 2014 ). One large cohort study even found an increased prevalence of 42.4% in subjects diagnosed with schizophrenia for non-right-handedness and 34.1% for mixed-handedness (Mallet et al 2022a ).…”

Section: Introductionmentioning

confidence: 66%

Behavioral lateralization in bipolar disorders: a systematic review

Mundorf,

Borawski,

Ocklenburg

2023

Int J Bipolar Disord

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Background Bipolar disorder (BD) is often seen as a bridge between schizophrenia and depression in terms of symptomatology and etiology. Interestingly, hemispheric asymmetries as well as behavioral lateralization are shifted towards a tendency of left-side or mixed-side bias in schizophrenia whereas no shift is observed in subjects with depression. Given the role of BD with both, (hypo)manic and depressive episodes, investigating hemispheric asymmetries in subjects with BD is an interesting objective. Method A systematic review of studies including measures of behavioral lateralization in the form of handedness, footedness, eyedness, and language lateralization was performed resulting in 25 suitable studies. Results A broad variety of methods was used to assess behavioral lateralization, especially for eyedness, footedness, and language lateralization hindering the integration of results. Additionally, for hand preference, studies frequently used different cut-off scores and classification systems. Overall, studies do not support alteration in side preference in BD subjects. Studies focusing on differences in handedness demonstrate that subjects show equal rates of right- and non-right-handedness as the general population. Few studies focusing on manic episodes point towards increased left-side bias in ear and eye dominance, but the small sample sizes and conflicting results warrant further investigation. Conclusion The results reinforce that some disorders, such as BD, should not be treated as a homogenous group but sub-groups should be analyzed within the patient’s population. Particularly, clinical implications resulting from neuroimaging studies highlight the need to study hemispheric asymmetries given that they may be important to consider for brain stimulation protocols.

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“…In several simulation studies, RoBMA was found to be superior to other bias correction methods [28]. RoBMA has been used notably in the field of psychology [31][32][33]. We used RoBMA to provide a sensitivity analysis of i) the publication bias detection, when the Egger's test was significant and ii) the evaluation of the publication bias effect, by providing a corrected ORRoBMA and comparing it to the ORUncorrected as previously described with the T&F method.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Publication bias in pharmacogenetics of statin-associated muscle symptoms, an umbrella review with a meta-epidemiological study

Gougeon,

Aribi,

Guernouche

et al. 2024

Preprint

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Background: Statin-associated muscle symptoms (SAMS) are a major cause of treatment discontinuation. Adjusting statin dosages for solute carrier organic anion transporter family member 1B1 (SLCO1B1) genotype has been proposed to reduce SAMS. We hypothesized that the association between SLCO1B1 genotype and SAMS is misestimated because of publication bias. Methods: We searched for published systematic reviews evaluating the association between SLCO1B1 genotype and SAMS. We collected the odds ratio (OR) of this association in each clinical study. We assessed the presence of publication bias using the visual inspection of a funnel plot and Egger?s test and used the Bayes Factor (BFPublication-bias) of the Robust Bayesian Meta-Analysis (RoBMA) as a sensitivity analysis. We evaluated the effect of publication bias by comparing qualitatively and quantitatively (ratio of OR [ROR]) OR of the meta-analysis i) uncorrected for potential publication bias (ORUncorrected) and ii) corrected using the trim-and-fill (ORTrim&Fill). We also used the RoBMA (ORRoBMA) for corrected OR as a sensitivity analysis. Our primary analysis covered the associations between any SLCO1B1 genotype and any statin drug. Secondary analysis focused on SLCO1B1 genotypes and statin drug subgroups. Results: We included 8 cohort and 11 case-control studies, totaling 62 OR of three SLCO1B1 genotypes and five statin drugs plus one ?mixed? statin treatment. All controls were statin-tolerant patients. In the primary analysis, the funnel plot was suggestive of publication bias, confirmed by Egger?s test (p=0.001) and RoBMA (BFPublication-bias=18). Correcting the estimate for publication bias resulted in loss of the association, from a significant ORUncorrected (1.31 95% CI [1.13?1.53]) to corrected ORs suggesting no difference: i) ORTrim&Fill (1.07 95% CI [0.89?1.30]) and ii) ORRoBMA (1.02 95% CI [1.00?1.33]). The RORTrim&Fill and the RORRoBMA suggested that publication bias overestimated the association by 18% and 23%, respectively. The results were similar for the most studied SLCO1B1 genotype, as for simvastatin and atorvastatin. Conclusion: The effect of the SLCO1B1 genotype on the risk of developing SAMS is overestimated in the published literature. This could lead prescribers to incorrectly decreasing statin doses or even avoiding statin use, leading to a loss of the potential cardiovascular benefit of statins.

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Handedness in post-traumatic stress disorder: A meta-analysis

Cited by 16 publications

References 62 publications

A deep phenotyping approach to assess the association of handedness, early life factors and mental health

A deep phenotyping approach to assess the association of handedness, early life factors and mental health

Behavioral lateralization in bipolar disorders: a systematic review

Publication bias in pharmacogenetics of statin-associated muscle symptoms, an umbrella review with a meta-epidemiological study

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