Handbook of Aqueous Solubility Data

Yalkowsky, Samuel H.; He, Yan; Jain, Parijat

doi:10.1201/ebk1439802458

Cited by 302 publications

(260 citation statements)

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“…The spectrophotometric method was also verified to determine the solubilities of glycine, oxalic acid and benzoic acid. It was found that our solubility data for glycine, oxalic acid and benzoic acid are in agreement with those published by Yang, [16] Yalkowsky [17] and Mulin, [18] respectively.…”

Section: Sucrose Solubility and Metastable Zone Width In A Pure Systemsupporting

confidence: 92%

Spectrophotometry as a Method for the Determination of Solubility of Sucrose in Water and Metastable Zone Width of its Aqueous Solutions

Borji

Jourani

2018

Crystal Research and Technology

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Using a spectrophotometer solubility of sucrose in aqueous solutions without and with glucose and fructose additives and their metastable zone width have been investigated. Comparison of our results from pure solutions with those published in the literature shows the reliability of the method. In agreement with the literature the experimental data also show that the impurities decrease the solubility of sucrose in water and the metastable zone width of the solutions.

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Section: Sucrose Solubility and Metastable Zone Width In A Pure Systemsupporting

confidence: 92%

Spectrophotometry as a Method for the Determination of Solubility of Sucrose in Water and Metastable Zone Width of its Aqueous Solutions

Borji

Jourani

2018

Crystal Research and Technology

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“…The solubility of succinic acid in water is about one order of magnitude higher than that of fumaric acid, 51 (Table 3) suggesting that counterion replacement has less impact on the salt solubility compared to the alteration in the crystal structure. In contrast to the pH 6.8 medium, the solubility values of CIP and NFX in an acidic pH 1.2 buffer solution are similar, indicating a significant increase in hydration energy of the protonated species.…”

Section: Solubility Of the Solid Forms At Different Ph Valuesmentioning

confidence: 99%

Diversity of crystal structures and physicochemical properties of ciprofloxacin and norfloxacin salts with fumaric acid

et al. 2018

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adThe crystallization of norfloxacin and ciprofloxacin -antibacterial fluoroquinolone compounds -with fumaric acid resulted in the isolation of six distinct solid forms of the drugs with different stoichiometries and hydration levels. Each salt can be selectively obtained by mechanochemical treatment in the presence of water/organic mixtures of a particular composition. The new phases were analysed using TG, DSC and PXRD, and their structural parameters were determined using single crystal X-ray diffraction. Despite having the same counterion, the ciprofloxacin and norfloxacin fumarates crystallise to form distinct crystal structures, which consequently determine the differences in the relative stability and the corresponding physicochemical properties of the solid forms. The influence of water activity (a w ) on the solid form stability and transformation pathways of anhydrous and hydrated fumarates was elucidated. The solubility and phase stability of the salts were also investigated in pharmaceutically relevant buffer solutions with pH 6.8 and pH 1.2. The largest solubility improvement relative to the parent drug (≈33 times) in the pH 6.8 medium was observed in the case of ciprofloxacin hemifumarate sesquihydrate. In turn, the norfloxacin fumarates showed a moderate 3-fold enhancement in solubility.

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“…Miller and Hawthorne [19] presented solubilities of D-limonene, carvone, eugenol, 1,8-cineole, and nerol in subcritical water; while Fichan et al [20] and Tamura and Li [21] investigated water solubilities of monoterpenes at 25°C. By searching compilation books such as "Handbook of Aqueous Solubility Data" [22] it is possible to gauge the limited, and high inconsistency of the available data.…”

Section: Introductionmentioning

confidence: 99%

Terpenes solubility in water and their environmental distribution

Martins

Silva

Ferreira

et al. 2017

Journal of Molecular Liquids

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Terpenes and terpenoids belong to the largest and most diverse class of natural products. Due to the increasing importance of their applications and the emerging perception of their impact on the environment, the available physico-chemical characterization is insufficient. In this work the water solubility of geraniol, linalool, DL-citronellol, thymol, eugenol, carvacrol and p-cymene, in the temperature range from (298.15 to 323.15) K, and at atmospheric pressure, is studied. Due to the low solubility of these compounds a novel technique was adopted for their measurements and validated using the aqueous solubility data for sparingly soluble aromatic compounds. The thermodynamic properties of solution were derived from the experimental data at infinite dilution. It is shown that the solubility of terpenes in water is an endothermic process confirming the existence of UCST phase diagrams, and only for carvacrol and eugenol is entropically driven. The experimental information is shown in a two-dimensional chemical space diagram providing indications to their probable distribution in the environment once released.

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Handbook of Aqueous Solubility Data

Cited by 302 publications

References 0 publications

Spectrophotometry as a Method for the Determination of Solubility of Sucrose in Water and Metastable Zone Width of its Aqueous Solutions

Spectrophotometry as a Method for the Determination of Solubility of Sucrose in Water and Metastable Zone Width of its Aqueous Solutions

Diversity of crystal structures and physicochemical properties of ciprofloxacin and norfloxacin salts with fumaric acid

Terpenes solubility in water and their environmental distribution

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