Handbook of African Medicinal Plants

“…In Nigeria, it is called "Ireke omode" in Yoruba, "Okpete" in Igbo, "Kakizawa" in Hausa, "Mbritem"in Efik and Anglophone Cameroon calls it "Monkey sugar cane" 10 . Costus afer is an indigenous West African medicinal plant of the family of Zingiberaceae.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Potential of Methanol Extract of <i>Costus Afer</i> Leaf on Carbon Tetrachloride-Induced Cardiotoxicity in Albino Rats

Njoku

Nwodo

Ogugofor

2017

AJPRHC

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Costus afer leaf extract is one of the native heritages of folklore medicine in Nigeria, used for the treatment of various disease conditions. Therefore this study was undertaken to evaluate the cardioprotective potential of the methanol extract of Costus afer leaves on CCl 4 -induced cardiotoxicity in albino rats. Twenty-eight (28) albino rats were divided into four main groups: normal control (normal saline only), CCl 4 control (saline and CCl 4 ), aspirin treated (1.2 mg/kg b.w aspirin and CCl 4 ) and Costus afer extract treated (extract and CCl 4 ) groups. Costus afer extract was administered in four doses; 100, 200, 300, and 400 mg/kg b.w. p.o for 7 days. On day 7, CCl 4 (2.5 ml) cardiotoxicity was induced in animals of CCl 4 control, aspirin treated and extract pre-treatment groups. The parameters studied in this respect were cardiac biomarker enzymes; Creatine Kinase (CK), Aspartate Transaminases (AST) and Lactate Dehydrogenase (LDH), serum lipid profile; Triacylglycerol (TAG), Total Cholesterol (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and artherogenic index (AR), lipid peroxidation; malondialdehyde (MDA) level and enzymatic antioxidant levels of cardiac tissue homogenate; Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Reductase (GR). CCl 4 intoxication produced significant (p < 0.05) increases in cardiac biomarker enzymes, serum lipid profile (TAG, TC, and LDL) along with enhanced lipid peroxidation in heart, while significant (p < 0.05) decreases in enzymatic antioxidant activities and HDL contents were also observed when compared to normal control. Costus afer leaf extract protected against CCl 4 cardiotoxic effect by restoring the cardiac functions alterations, augmenting antioxidant activities, reducing lipid peroxidation and improving lipid profile levels near normal. From the results, Costus afer leaves expressed cardioprotective potential and could be helpful in the management of cardiac dysfunction.

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“…They are prescribed for dyspepsia and opacities of the cornea 17 . To complete the range of its applications, one could mention its use as an insecticide, in which case its juice is poured on to anthills, and also its ornamental use in Roman and medieval gardens 28 . Another authority declared that the distilled water took away pains in the teeth, the seeds, bruised and boiled in wine, were given to children as a vermifuge 36 .…”

Section: General Benefitsmentioning

confidence: 99%

“…The seeds are also calmative and will help slake a thirst 9 . An infusion is used as anthelmintic for children to expel roundworms, in high doses as an emetic and also as a cooling drink, with a mild diuretic effect 28 .…”

Section: General Benefitsmentioning

confidence: 99%