Hämorrhagische Diathesen bei Lebererkrankungen unter besonderer Berücksichtigung der Thrombocytenfunktion

Breddin, K

doi:10.1159/000206746

Cited by 22 publications

(2 citation statements)

References 7 publications

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“…Haemostatic defects in liver disease may be associated with a decrease in coagulation factors (Rapaport et al, 1960), an increase in fibrinolytic activity (Fletcher et al, 1964), thrombocytopenia (Ratnoff et al, 1950), and qualitative platelet defects (Breddin, 1962). Evidence of disseminated intravascular coagulation (DIC) was first reported in patients with cirrhosis of the liver by Bergstrom et al (1960).…”

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confidence: 99%

Modification of factor VIII complex properties in patients with liver disease.

Maisonneuve¹,

Sultan²

1977

J Clin Pathol

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Factor VIII procoagulant activity (VIII:C), factor VIII related antigen (VIIIR:AG), and the von Willebrand factor (VIII:WF) were measured in 19 patients with liver disease (8 cases of alcoholic cirrhosis and 11 with acute viral hepatitis). In both groups of patients the levels of VIII:C, VIIIR:AG, and VIIIR:WF were above normal or normal with mean values well above the normal range. VIIR:AG was also measured in the same patients by two-dimensional electrophoresis, and its biological properties were measured after purification by chromatography. By both methods the VIIIR: AG in the patients with liver disease differed from normal VIIIR:AG. In five of the patients with acute viral hepatitis, who were tested after they had recovered, the previously elevated levels of VIII:C, VIIIR:AG, and VIIIR:WF had dropped to normal limits and the qualitative abnormalities had disappeared.

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confidence: 99%

Modification of factor VIII complex properties in patients with liver disease.

Maisonneuve¹,

Sultan²

1977

J Clin Pathol

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“…It is well known that liver cirrhosis is often accompanied by deficiencies in the plasma content of several coagulation factors (16,17,33), increased fibrinolytic activity ( I , 15,16), as well as thrombocytopenia (2,31) and probably qualitative platelet changes (7,20). Increased capillary fragility has also been reported Lowered coagulation factor levels in liver parenchymal disease have been ascribed b y most investigators to decreased synthesis (22,30,32,35).…”

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confidence: 99%