Halothane–associated enhancement of the secondary immune response to sheep erythrocytes in mice: cell transfer studies

Puig, N; Elena, G; Barragan, J.; Comba, J. O.; Amerio, N

doi:10.1111/j.1399-6576.1993.tb03782.x

Cited by 11 publications

(13 citation statements)

References 17 publications

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“…In response to anaesthetic exposure, humoral parameters, such as the number of immunoglobulin G secreting cells, are altered in animal studies [19,20]. Exposure to low concentrations of volatile anaesthetics seems to inhibit predominantly T-helper cell function [11].…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to low concentrations of volatile anaesthetics seems to inhibit predominantly T-helper cell function [11]. It has been reported that low concentrations of anaesthetics preferentially impair T cell activity, whereas higher concentrations also affect B cells [19,20]. This effect could be explained by impaired T-helper cell activity that adversely affects B cell activity.…”

Section: Discussionmentioning

confidence: 99%

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Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

Gruber

Lirk²,

Amann

et al. 2002

Anaesthesia

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SummaryPersonnel working in operating theatres and recovery rooms are exposed to a variety of noxious substances. The results of studies of the effects of occupational exposure on immune parameters are conflicting. Neopterin is an acknowledged marker of immunostimulation. Urinary neopterin levels of 58 anaesthetists and anaesthetic nurses were measured over a 3-week period. Neopterin analyses were performed using high performance liquid chromatography. Neopterin levels were within the normal range for all subjects. Younger subjects (aged £ 35 years) had significantly higher urinary neopterin concentrations than older subjects (aged > 35 years). The present study is the first to investigate the influence of anaesthetic exposure on neopterin levels. No evidence of immunostimulation was found.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

Gruber

Lirk²,

Amann

et al. 2002

Anaesthesia

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“…Inhalatory anaesthetic may either produce reversible and short-term alterations on cellular functions or cause acute and chronic toxicity as a result of the formation of intermediate and end metabolic compounds (Rice & Fish 1994). Our group studied the effect of several inhalatory anaesthetics on components of the immune response as well as on their functional activities, both in vivo and in vitro in a mouse model (Puig et al 1993(Puig et al , 1995. We found an enhancement of the humoral response upon repeated halothane exposure.…”

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confidence: 99%

Effects of repetitive sevoflurane anaesthesia on immune response, select biochemical parameters and organ histology in mice

et al. 2003

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SummaryAnimal and technical models often require repeated anaesthetic administrations for surgical procedures. As there is evidence for immunomodulatory effects of anaesthesia, the effects of repeated exposure to sevo urane anaesthesia on the immune response in mice were studied. Sevo urane was administered in vivo under conditions that simulate those in clinical procedures. Adult male mice were anaesthetized with 3% sevo urane in oxygen for 40 min weekly for 3 weeks. Untreated animals served as controls. After sevo urane anaesthesia, peripheral blood leukocyte counts, the composition and in vitro function of spleen cells (lymphocytes and macrophages) and the in vivo immune response to a conventional T-dependent antigen were assessed. In addition, liver, spleen and kidney histopathology and also hepatic and renal function were studied. Three days after the latest anaesthetic procedure, the absolute number of both leukocyte and lymphocyte counts were reduced in peripheral blood. Splenic cell composition (LB, LTCD3‡ , LTCD4 ‡ and LTCD8 ‡ ), macrophage function and the mitogen-induced lymphoprolipherative response were preserved. Yet, the in vivo humoral response to a conventional antigen was augmented following the antigenic challenge. Assessment at day 9 after the last anaesthetic procedure revealed the persistence of the humoral response alteration. Nevertheless, sevo urane-treated animals showed no evidence of histological changes or alteration in hepatic or renal function.

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“…activation. Halothane increases the antibody titre 8 , and, as sevoflurane does, it increases the primary and secondary responses 5,8,9,20,21,27 .…”

Section: Il-6mentioning

confidence: 99%

“…Thus, part of the effect of anaesthetics on the immune system would be due to its action on the well-known immunomodulatory effect of glucocorticoids 3 . Diverse in vitro experiments with human immune cells 4 , ex vivo [5][6][7] , in vivo [8][9][10] or animal models have been used to study the effect of anaesthetic drugs on the immune system. .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2013

OA Anaesthetics

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IntroductionThe immune system protects us from infections through coordinate action of its components. Patients and animals undergoing anaesthesia and surgery show alterations in the immune response. In this paper, we review the effects of some of the most common anaesthetic drugs on the immune system, in particular the effects within 24 hours after their administration, describing their effects on cells and cytokines of the innate and acquired immune system. Discussion As it is difficult to isolate the effects of anaesthetic drugs in the case of surgery, diverse in vitro studies with human immune cells or in vivo with animal models have been used to study the effect of anaesthetic drugs on the immune system. These studies have demonstrated diverse effects, such as changes in immune cell counts and functionality, and on the secretion patterns of diverse cytokines affecting the inflammatory response in the postoperative period. Conclusion Effects of anaesthetic drugs on the immune system are clinically important because the amount and function of the immune cells, as well as the balance between pro-and anti-inflammatory cytokines secretion, are related to postoperative infections and tissue injury.

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Halothane–associated enhancement of the secondary immune response to sheep erythrocytes in mice: cell transfer studies

Cited by 11 publications

References 17 publications

Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

Effects of repetitive sevoflurane anaesthesia on immune response, select biochemical parameters and organ histology in mice

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