Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.

Yamada, Takeshi; Kogure, Haruka; Kataoka, Mikiko; Kikuchi, Takashi; Hirano, Tomoya

doi:10.3390/md18060320

Cited by 13 publications

(4 citation statements)

References 30 publications

(65 reference statements)

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“…208 A macrodiolide 540 was isolated from a Halosphaeriaceae strain. 209 Hypoxylon rubiginosum yielded compound 541, in addition to 542 and 543 as new MNPs 210 and polyketides 544-550 were obtained from a Letendraea strain. 211 Microsphaeropsis sp.…”

Section: Cyanobacteriamentioning

confidence: 99%

Marine natural products

et al. 2022

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Section: Cyanobacteriamentioning

confidence: 99%

Marine natural products

et al. 2022

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“…However, the family Halosphaeriaceae has been reported as producers of the substance Halosmysin A, which exhibits activity against leukemias. (Yamada et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Tapping into Tapajos: antibacterial potential of fungal strains isolated from decaying wood in the Brazilian Amazon

Canto,

Bentes,

Silva

et al. 2023

Braz. J. Biol.

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The emergence of bacterial resistance to antimicrobials poses a significant health threat. To address this issue, exploring the fungal diversity in freshwater environments in the Amazon Forest has potential in the search for new antimicrobials. This study aimed to investigate the production of antibacterial metabolites by aquatic fungi from Amazon lakes, specifically Lake Juá and Lake Maicá (Brazil-PA). The fungal isolates were obtained from wood fragments submerged in these lakes, and the ethyl acetate extracts were evaluated for antibacterial activity against Staphylococcus aureus ATCC 25923, S. aureus (MRSA), ATCC 43300, Escherichia coli ATCC 25922, and E. coli (ESBL) NCTC 13353. Additionally, toxicity of the extracts (EtOAc with antimicrobial activity) against human fibroblasts MRC-5 was investigated. The study identified 40 fungal strains with antimicrobial screening, and the ethyl acetate extracts of Fluviatispora C34, Helicascus C18, Monodictys C15, and Fusarium solani LM6281 exhibited antibacterial activity. F. solani LM6281 showed the lowest minimum inhibitory concentration (MIC) of 50 µg/mL against S. aureus strains and MIC of 100 µg/mL against E. coli strains including ESBL. The cytotoxicity (IC50) of the extract (EtOAc) of F. solani LM6281 was 34.5 µg/mL. Preliminary studies of the TLC culture and RNM-H from the extract (EtOAc) of F. solani suggested the presence of substances from the class of terpenes, quinones, phenolics, and flavonoids. This study highlights the potential of submerged wood fungi in the Amazon region to produce antibacterial substances, thus identifying them as sources of novel bioactive compounds with potential use in the pharmaceutical industry and regional bioeconomy.

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“…It shows potent cancer cell growth inhibitory properties. [ 110 ] A marine‐derived Eurotium sp. produced a pair of salicylaldehyde derivative enantiomer (+)‐and (−)‐euroticin A ( 113 ), which features an unusual 6/6/6/5/7 pentacyclic skeleton.…”

Section: Hot‐spot Compoundsmentioning

confidence: 99%

Structural and Biological Insights into the Hot‐Spot Marine Natural Products Reported from 2012 to 2021

Zhang

2022

Chin. J. Chem.

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Comprehensive Summary The vast marine ecosystem contains a sea of natural products, which are potential model molecules for new drug development. With more than one thousand new structures been discovered each year, the past decade has become the golden time for marine natural product discovery, leading to a valuable but extra‐large chemical database. Serving as an epitome of the most promising compounds, which take the ultra‐new skeletons and/or excellent bioactivities, this review covers 243 hot‐spot marine natural products reported from 2012 to 2021, to abstract some important chemical and/or biological inspirations for marine natural product study and marine drug development in the future. In addition, some general rules regarding to the source organism, structure‐specialty, organism‐structure specificity, and organism‐bioactivity relationship of these outstanding compounds will also be presented.

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Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.

Cited by 13 publications

References 30 publications

Marine natural products

Marine natural products

Tapping into Tapajos: antibacterial potential of fungal strains isolated from decaying wood in the Brazilian Amazon

Structural and Biological Insights into the Hot‐Spot Marine Natural Products Reported from 2012 to 2021

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