Halophilic Bacteria: Potentials and Applications in Biotechnology

Mohammadipanah, Fatemeh; Hamedi, Javad; Dehhaghi, Mona

doi:10.1007/978-3-319-14595-2_11

Cited by 26 publications

(10 citation statements)

References 276 publications

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“…Microorganisms are capable of producing a wide range of metabolites from antibiotics, [1][2][3] pigments, 4 and vitamins, to antioxidants, 5,6 enzymes, 7 and toxins. 8 They can exert positive or negative effects through the production of some of these metabolites when they live in the human body as microbiota.…”

Section: Introductionmentioning

confidence: 99%

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Dehhaghi

Panahi

Guillemin

2019

Int J�Tryptophan�Res

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137

122

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The kynurenine pathway is important in cellular energy generation and limiting cellular ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD+ (nicotinamide adenine dinucleotide). Prior to the production of NAD+, various intermediate compounds with neuroactivity (kynurenic acid, quinolinic acid) or antioxidant activity (3-hydroxykynurenine, picolinic acid) are synthesized. The kynurenine metabolites can participate in numerous neurodegenerative disorders (Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, and Parkinson disease) or other diseases such as AIDS, cancer, cardiovascular diseases, inflammation, and irritable bowel syndrome. Recently, the role of gut in affecting the emotional and cognitive centres of the brain has attracted a great deal of attention. In this review, we focus on the bidirectional communication between the gut and the brain, known as the gut-brain axis. The interaction of components of this axis, namely, the gut, its microbiota, and gut pathogens; tryptophan; the kynurenine pathway on tryptophan availability; the regulation of kynurenine metabolite concentration; and diversity and population of gut microbiota, has been considered.

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Section: Introductionmentioning

confidence: 99%

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Dehhaghi

Panahi

Guillemin

2019

Int J�Tryptophan�Res

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137

122

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“…Microorganisms occur ubiquitously and have abilities to metabolize a diverse range of metabolites ranging from enzymes (Hamedi et al, 2015;Mohammadipanah et al, 2015), therapeutic lead compounds (Mohammadipanah et al, 2016;Sajedi et al, 2018), and antioxidants (Dehhaghi et al, 2018b(Dehhaghi et al, , 2019a(Dehhaghi et al, ,c, 2020 to hydrocarbon-rich compounds, i.e., ethanol (Dehhaghi et al, 2019a;Kazemi Shariat Panahi et al, 2019b), butanol (Dehhaghi et al, 2019b), and methane (Dehhaghi et al, 2019b;Tabatabaei et al, 2019).…”

Section: The Gut Microbiota-brain Axismentioning

confidence: 99%

The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer

Dehhaghi

Panahi

Heng

et al. 2020

Front. Cell Dev. Biol.

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Human gut microbiota contains a large, complex, dynamic microbial community of approximately 10 14 microbes from more than 1,000 microbial species, i.e., equivalent to 4 × 10 6 genes. Numerous evidence links gut microbiota with human health and diseases. Importantly, gut microbiota is involved in the development and function of the brain through a bidirectional pathway termed as the gut-brain axis. Interaction between gut microbiota and immune responses can modulate the development of neuroinflammation and cancer diseases in the brain. With respect of brain cancer, gut microbiota could modify the levels of antioxidants, amyloid protein and lipopolysaccharides, arginase 1, arginine, cytochrome C, granulocytemacrophage colony-stimulating factor signaling (GM-CSF), IL-4, IL-6, IL-13, IL-17A, interferon gamma (IFN-γ), reactive oxygen species (ROS), reactive nitrogen species (e.g., nitric oxide and peroxynitrite), short-chain fatty acids (SCFAs), tryptophan, and tumor necrosis factor-β (TGF-β). Through these modifications, gut microbiota can modulate apoptosis, the aryl hydrocarbon receptor (AhR), autophagy, caspases activation, DNA integrity, microglia dysbiosis, mitochondria permeability, T-cell proliferation and functions, the signal transducer and activator of transcription (STAT) pathways, and tumor cell proliferation and metastasis. The outcome of such interventions could be either oncolytic or oncogenic. This review scrutinizes the oncogenic and oncolytic effects of gut microbiota by classifying the modification mechanisms into (i) amino acid deprivation (arginine and tryptophan); (ii) kynurenine pathway; (iii) microglia dysbiosis; and (iv) myeloid-derived suppressor cells (MDSCs). By delineating the complexity of the gutmicrobiota-brain-cancer axis, this review aims to help the research on the development of novel therapeutic strategies that may aid the efficient eradication of brain cancers.

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“…This has led to their applications in astrobiology, agriculture, food and nutrition industry, biosensor development and photochemical industry, bioremediation, textile and tanning industry, aquaculture, nanotechnology, sustainable chemical production and medical application (Le Borgne et al 2008;Lee 2013;Margesin and Schinner 2001;Rodrigo-Baños et al 2015). Several reviews on the biotechnologically valuable products generated by halophiles and their potential applications have been recently published (Antunes et al 2017;DasSarma et al 2010a;Mohammadipanah et al 2015;Oren 2010;Yin et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Haloferax volcanii for biotechnology applications: challenges, current state and perspectives

Haque

Paradisi

Allers

2019

Appl Microbiol Biotechnol

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Haloferax volcanii is an obligate halophilic archaeon with its origin in the Dead Sea. Simple laboratory culture conditions and a wide range of genetic tools have made it a model organism for studying haloarchaeal cell biology. Halophilic enzymes of potential interest to biotechnology have opened up the application of this organism in biocatalysis, bioremediation, nanobiotechnology, bioplastics and the biofuel industry. Functionally active halophilic proteins can be easily expressed in a halophilic environment, and an extensive genetic toolkit with options for regulated protein overexpression has allowed the purification of biotechnologically important enzymes from different halophiles in H. volcanii. However, corrosion mediated damage caused to stainless-steel bioreactors by high salt concentrations and a tendency to form biofilms when cultured in high volume are some of the challenges of applying H. volcanii in biotechnology. The ability to employ expressed active proteins in immobilized cells within a porous biocompatible matrix offers new avenues for exploiting H. volcanii in biotechnology. This review critically evaluates the various application potentials, challenges and toolkits available for using this extreme halophilic organism in biotechnology.

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Halophilic Bacteria: Potentials and Applications in Biotechnology

Cited by 26 publications

References 276 publications

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer

Haloferax volcanii for biotechnology applications: challenges, current state and perspectives

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