Haloperidol induced Parkinson’s disease mice model and motor-function modulation with Pyridine-3-carboxylic acid

Saeed, Atif; Shakir, Lubna; Khan, Mahtab Ahmad; Ali, Arsalan; Zaidi, Awais Ali

doi:10.15419/bmrat.v4i05.169

Cited by 19 publications

(9 citation statements)

References 18 publications

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“…The tendency of a mouse to stay on the respective bar for a given time without falling will show the grip strength and reduced cataleptic state (Deacon, 2013). In the triple horizontal bar apparatus, the cataleptic score was increased in RC 20 mg/kg treated mice as compared to DCG so they have more grip strength due to improvement of motor function which is following other studies (Saeed et al, 2017).…”

Section: Discussionsupporting

confidence: 59%

Appraisal of anti‐Parkinson activity of rhinacanthin‐C in haloperidol‐induced parkinsonism in mice: A mechanistic approach

et al. 2021

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Parkinson's disease (PD), the second most prevalent neurodegenerative disorder presented by impaired motor coordination (muscle rigidity, tremor, postural imbalance, and slowness of movements) and non-motor symptoms (mood disorders, sleep disorders, and cognitive deficit) (Malaiwong et al., 2019). Globally, 10 million individuals are suffering from PD. It affects 2-3% of people more than 65 years of age (Poewe et al., 2017). Neuropathologically, it is attributed to dopaminergic neuronal loss primarily in substantia nigra, accumulation

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Section: Discussionsupporting

confidence: 59%

Appraisal of anti‐Parkinson activity of rhinacanthin‐C in haloperidol‐induced parkinsonism in mice: A mechanistic approach

et al. 2021

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“…Neurodegeneration and neuronal dysfunction are considerably modulated by oxidative stress and neuroinflammation, leading to the reduction of various antioxidants. e reported prevalence of PD increases from 1 to 5% with an increase in age from 65 to 85 years, respectively, and is more occurring in men than women [5,38], and this gender discrimination is attributed to the neuroprotective effect of estrogen in females [39][40][41]. e neuropathological mechanisms of PD are multifactorial and include genetic and nongenetic as well as environmental factors, while the etiology of PD is still largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model

Saleem

Hussain

Shahid

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Parkinson’s disease (PD) is a complex, age-related neurodegenerative disease that causes neuronal loss and dysfunction over time. An imbalance of redox potential of oxidative stress in the cell causes neurodegenerative diseases and dysfunction of neurons. Plants are a rich source of bioactive substances that attenuate oxidative stress in a variety of neurological disorders. The aim of the present study was to evaluate the Prunus armeniaca L. methanolic extract (PAME) for anti-Parkinson activity in rats. PD was induced with haloperidol (1 mg/kg, IP). The PAME was administered orally at 100, 300, and 800 mg/kg dose levels for 21 days. Behavioral studies (catalepsy test, hang test, open-field test, narrow beam walk, and hole-board test), oxidative stress biomarkers (SOD, CAT, GSH, and MDA) levels, neurotransmitters (dopamine, serotonin, and noradrenaline) levels, and acetylcholinesterase activity were quantified in the brain homogenate. Liver function tests (LFTs), renal function tests (RFTs), complete blood count (CBC), and lipid profiles were measured in the blood/serum samples to note the side effects of PAME at the selected doses. Histopathological analysis was performed on the brain (anti-PD study), liver, heart, and kidney (to check the toxicity of PAME on these vital organs). Motor functions were improved in the behavioral studies. Dopamine, serotonin, and noradrenaline levels were significantly increased ( P < 0.001 ), whereas the level of acetylcholinesterase was decreased significantly ( P < 0.001 ). The levels of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were increased, while malondialdehyde (MDA) and nitrite levels were decreased in the PAME-treated groups significantly compared with the disease control group, hence reducing oxidative stress. The incidence of toxicity was determined by biochemical analysis of LFT and RFT biomarkers testing. The histopathological analysis indicated that neurofibrillary tangles and plaques decreased in a dose-dependent manner in the PAME-treated groups. Based on the data, it is concluded that PAME possessed good anti-Parkinson activity, rationalizing the plant’s traditional use as a neuroprotective agent.

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“…It is generally accepted that haloperidol, a non-selective dopaminergic receptor antagonist, possess the property of providing an empiric experimental model of Parkinson's disease in rodents due to its anti-dopaminergic mechanism of action and neurotoxicity, favoring bradykinesia and late dyskinesia [31]. However, the most obvious manifestation produced by haloperidol is catalepsy, following D 2 receptor blockade [16,32].…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of metformin on haloperidol-induced motor deficits in rats. A behavioral assessment

Jîtcă

Gáll

Vari

et al. 2021

Acta Marisiensis - Seria Medica

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Objective: One of the most common side effects of haloperidol is the extrapyramidal syndrome, resulting from inhibition of nigrostriatal dopaminergic circuits and mitochondrial dysfunction due to structural similarities to pyridinium derivative, MPP+ that induce oxidative stress. In exchange, the use of metformin appears to enhance neurogenesis, energy metabolism, and oxidative status, so these properties can be speculated in the context of drug-induced pseudoparkinsonism by haloperidol. Methods: To assess motor coordination and activity, rodents were divided into four groups: CTR (n = 10) - animals that received distilled water, METF (n = 10) - animals that received metformin 500 mg / kgbw, HAL (n = 10) - animals that received haloperidol 2mg / kgbw, HALMETF (n = 10) - haloperidol 2mg / kgbw and metformin 500 mg / kgbw. The treatment was administered for 34 days at the same time by gastric gavage, during which time behavioral tests, rotarod (days 7, 14, 21, 28), catalepsy (day 30), open field (day 32) and novel object recognition (day 34) were performed. Results: The monitored parameters, showed significant differences between the groups of interest (HAL and HALMETF respectively), so that the administration of metformin at the beginning of treatment reduces the cataleptic behavior. The HALMETF group shows an attenuation of the motor deficit during the rotarod test and the freezing period from the Open Field test, is diminished. Conclusions: Metformin treatment has a beneficial effect in haloperidol-treated rats, demonstrated by decreased cataleptic behavior, improved motor performance and reduced haloperidol-induced anxiety behavior.

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Haloperidol induced Parkinson’s disease mice model and motor-function modulation with Pyridine-3-carboxylic acid

Cited by 19 publications

References 18 publications

Appraisal of anti‐Parkinson activity of rhinacanthin‐C in haloperidol‐induced parkinsonism in mice: A mechanistic approach

Appraisal of anti‐Parkinson activity of rhinacanthin‐C in haloperidol‐induced parkinsonism in mice: A mechanistic approach

Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model

Beneficial effects of metformin on haloperidol-induced motor deficits in rats. A behavioral assessment

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