2021
DOI: 10.2478/amma-2021-0017
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Objective: One of the most common side effects of haloperidol is the extrapyramidal syndrome, resulting from inhibition of nigrostriatal dopaminergic circuits and mitochondrial dysfunction due to structural similarities to pyridinium derivative, MPP+ that induce oxidative stress. In exchange, the use of metformin appears to enhance neurogenesis, energy metabolism, and oxidative status, so these properties can be speculated in the context of drug-induced pseudoparkinsonism by haloperidol. Methods: To assess mot… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(2 citation statements)
references
References 36 publications
0
2
0
Order By: Relevance
“…In contrast to MPTP, haloperidol does not cause neurodegeneration [ 20 ]. Haloperidol can induce extrapyramidal effects (mainly pseudo-parkinsonian symptoms such as catalepsy) by blocking postsynaptic D2 dopaminergic receptors in the mesolimbic system [ 22 ]. Catalepsy is a behavioral state of bradykinesia and rigidity in which the animal cannot correct externally imposed postures.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In contrast to MPTP, haloperidol does not cause neurodegeneration [ 20 ]. Haloperidol can induce extrapyramidal effects (mainly pseudo-parkinsonian symptoms such as catalepsy) by blocking postsynaptic D2 dopaminergic receptors in the mesolimbic system [ 22 ]. Catalepsy is a behavioral state of bradykinesia and rigidity in which the animal cannot correct externally imposed postures.…”
Section: Resultsmentioning
confidence: 99%
“…Neuroleptic-induced catalepsy has long been used as an animal model for screening drugs for parkinsonism, as described before [ 10 , 22 ]. Adult male Wistar rats were divided into four groups, each containing six animals.…”
Section: Methodsmentioning
confidence: 99%