Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells

Konishi, Izumi; Hosokawa, Masashi; Sashima, Tokutake; Kobayashi, Hidetaka; Miyashita, Kazuo

doi:10.1016/j.cbpc.2005.10.005

Cited by 90 publications

(64 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hosokawa et al reported that fucoxanthin (at least 7.6 μM for 48 h) caused DNA fragmentation indicating apoptosis, which was partially inhibited by a caspase inhibitor, and that it reduced the BCL2 protein level in Caco-2 human colon cancer cells, all of which led them to conclude that BCL2 may contribute to apoptosis induced by fucoxanthin (24). In another report by the same group, fucoxanthin (25 μM) was shown to induce apoptosis in MCF-7 human breast cancer cells (25). Apoptosis was induced by 5-40 μg/ml of fucoxanthin (7.6-60.7 μM), as indicated by DNA ladder and morphological changes in lung cancer cells NSCLC-N6 and A549 cells (26).…”

Section: Fucoxanthin Inhibits Tumor Cell Growth By Inducing G 1 Cell-mentioning

confidence: 95%

Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid

Satomi

2017

View full text Add to dashboard Cite

Section: Fucoxanthin Inhibits Tumor Cell Growth By Inducing G 1 Cell-mentioning

confidence: 95%

Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid

Satomi

2017

View full text Add to dashboard Cite

“…FX as well as its metabolite FXOH have been shown to reduce the expression of per-L1 preadipocytes, which in turn resulted in the inhibited differentiation to mature adipocytes (Maeda et al, 2006), suggesting that FX also acts as an inhibitor against adipocyte maturation in addition to being a stimulator for UCP1 expression in WAT. Beside the antiobesity effect, it has been reported that dietary FX or FXOH increases the amount of docosahexaenoic acid (DHA) in the liver of KKAy mice (Tsukui et al, ly important benefits (Fischer et al, 2008;Harris et al, 2008;Kelley et al, 2008;Lindmark and Clough et al In vitro and in vivo studies further revealed that FXOH and/or FX possesses antioxidant activity (Sachindra et al -ity against different kinds of cancer cells (Das et al, 2008;Ishikawa et al, 2008;Konishi et al, 2006;Satomi (Shiratori et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice

Beppu¹,

Niwano²,

Tsukui

et al. 2009

J. Toxicol. Sci.

Self Cite

151

View full text Add to dashboard Cite

-Fucoxanthin (FX), a xanthophyll derivative, is an orange-colored pigment present in edible brown algae. As a part of safety evaluation, single and repeated oral dose toxicity study of FX was ICR mice at doses of 1,000 and 2,000 mg/kg. In a repeated doses study, FX at doses of 500 and 1,000 appearance were observed. In the repeated doses study, histological observation revealed no abnormal -ly increased total cholesterol concentrations were shown by plasma biochemical analyses in all FX-treated groups. Although total bilirubin concentrations were increased by FX, it was established that presence of fucoxanthinol, a major metabolite of FX, interfered with bilirubin determination in plasma. To further ascertain the safety of FX, the mechanism by which FX induces hypercholesterolemia in mice and species differences in the induction of hypercholesterolemia should be elucidated.

show abstract

“…Previous studies have shown that holocynthiaxanthin exhibits an antiproliferative effect on various tumor cells 3) , inhibition of reverse transcriptases of immunodeficiency viruses 4) , and suppression of both superoxide and nitric oxide generation 5) . We and others have also reported that halocynthiaxanthin and fucoxanthinol induce apoptosis in human leukemia, colon and breast cancer cells 6,7) . However, there are no reports concerning the health benefits of alloxanthin and diatoxanthin, which are the major carotenoids in H. roretzi.…”

Section: Introductionmentioning

confidence: 99%

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

et al. 2008

Self Cite

View full text Add to dashboard Cite

To investigate anti-inflammatory effects of carotenoids from Halocynthia roretzi, gene expression levels were measured for pro-inflammatory cytokines and enzymes in the murine macrophage-like cell line, RAW264.7, stimulated with lipopolysaccharide (LPS). All-trans alloxanthin, all-trans diatoxanthin, and their 9-cis isomers isolated from H. roretzi significantly suppressed expression of IL-1b and IL-6 mRNA in cells induced by LPS without cytotoxicity. The expression level of IL-1b mRNA in cells treated with 25 mM all-trans alloxanthin for 24 h, followed by stimulation with 0.1 mg/mL LPS for 24 h in the presence of carotenoid decreased to 33.7±3.0% from that of control cells stimulated with LPS alone. All-trans diatoxanthin, 9-cis alloxanthin and 9-cis diatoxanthin also decreased expression of IL-1b mRNA to 25.1±2.1, 28.2±0.9 and 32.9±3.3%, respectively, from that of control cells stimulated with LPS. IL-1b production in culture medium was also suppressed by all-trans alloxanthin and all-trans diatoxanthin. Furthermore, all-trans alloxanthin, all-trans diatoxanthin and their 9-cis isomers suppressed the overexpression of cyclooxygenase-2 and nitric oxide synthase mRNA in RAW264.7 cells induced by LPS. The suppressive effects of these carotenoids were remarkable compared to those of b-carotene and zeaxanthin.

show abstract

Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells

Cited by 90 publications

References 14 publications

Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid

Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid

Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

Contact Info

Product

Resources

About