Hallucinations in narcolepsy with and without cataplexy: Contrasts with Parkinson’s disease

Leu‐Semenescu, Smaranda; Cock, Valérie Cochen De; Masson, V. Dauriac–Le; Debs, Rachel; Lavault, Sophie; Roze, Emmanuel; Vidailhet, Marie; Arnulf, Isabelle

doi:10.1016/j.sleep.2011.03.006

Cited by 57 publications

(44 citation statements)

References 42 publications

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“…In another detailed clinical interview, Leu-Semenescu et al found the prevalence of hallucinations to be 26% (26/100 PD patients). In almost half of the hallucinating PD patients, the prevalence of hallucinations clearly associated with sleep onset or offset was 12% (12/100 PD patients) [31]. In the present questionnaire study, we found these occurrences less frequent, that is, the prevalence of any hallucination as 17.2% and of hallucination with sleep onset or offset as 8.3%.…”

Section: Discussioncontrasting

confidence: 39%

Parkinson's disease and narcolepsy-like symptoms

et al. 2015

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Section: Discussioncontrasting

confidence: 39%

Parkinson's disease and narcolepsy-like symptoms

et al. 2015

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“…Hallucinations occur in up to 66% of patients with narcolepsy and cataplexy (Billiard et al 1983 ) . In a recent series of 100 patients with narcolepsy, hallucinations were more frequent in patients with cataplexy (59%) than in those without cataplexy (28%) (Leu-Semenescu et al 2011 ) . Sleep-onset and sleep-offset hallucinations are more severe in narcoleptic patients than in healthy subjects.…”

Section: Hypnagogic and Hypnopompic Hallucinationsmentioning

confidence: 96%

“…Even if patients are retrospectively well aware of the nature of these phenomena, some report dif fi culty in differentiating dreams from reality and might occasionally be misdiagnosed as schizophrenia. However, delusional thinking is exceptional (Dauvilliers et al 2007 ;Fortuyn et al 2009 ;Leu-Semenescu et al 2011 ) .…”

Section: Hypnagogic and Hypnopompic Hallucinationsmentioning

confidence: 99%

Hallucinations Associated with Neurological Disorders and Sensory Loss

Fénelon

2012

The Neuroscience of Hallucinations

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Hallucinations occur in a great variety of neurological conditions and are facilitated by sensory loss. The common end pathway of their pathophysiology involves the activation of cortical sensory areas implicated in normal sensory processing. Based on the presumed pathophysiology, we here classify the hallucinations in four main groups. In migraine aura and epilepsy, hallucinations result from spontaneous intrinsic overactivity in hyperexcitable sensory cortical areas. Deafferentation, i.e. the loss or impairment of sensory input, facilitates hallucinations in the corresponding sensory modality, probably by leading to chronic hyperexcitability of the corresponding cortical areas. The archetypal example of this mechanism is the Charles Bonnet syndrome, where hallucinations are associated with visual impairment. A third mechanism relies on the dissociation of dream and sleep mechanism, as illustrated by hypnagogic and hypnopompic hallucinations. Finally, in the course of neurodegenerative diseases such as Parkinson's disease and dementia with Lewy bodies, hallucinations are frequent and probably result from a combination of factors, including dysfunction of both bottomup sensory processing and top-down modulatory mechanisms, as well as dream intrusion phenomena and facilitating pharmacological factors.

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“…Kita studija taip pat pateikė panašius rezultatus: apie 80% narkoleptikų per savo gyvenimą yra patyrę haliucinacijų, iš kurių 65% buvo hipnagoginės arba hipnopompinės (35). Hipnagoginės ir hipnopompinės haliucinacijos neretai buvo lydimos taktilinių, taip pat ir regos bei klausos haliucinacijų (žingsniai, muzika, labai retais atvejais žmonių balsai) (35,36). Vienas iš patologinių mechanizmų, kodėl žmonės suserga narkolepsija, sietinas su hipokretiną sintezuojančių neuronų, esančių šoninėje pogumburio dalyje, žūtimi.…”

Section: Darbo Uždaviniai Ir Metodikaunclassified