Half sandwich platinum group metal complexes of thiourea derivative ligands with benzothiazole moiety possessing anti-bacterial activity and colorimetric sensing: Synthesis and characterisation

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

“…The solvents used for synthesis were dried and distilled prior to use according to the standard procedures [14]. The precursor ruthenium complex [(arene)RuCl2]2 was synthesized following the reported procedure [15] and [Cp*MCl2]2 (M = Rh/Ir) complexes were prepared using a synthesizer, Anton par mono-wave 50 [16].…”

In vitrobiological evaluation of half-sandwich platinum-group metal complexes containing benzothiazole moiety

“…The drying and distilling of the solvents were done in accordance with the standard procedures. Starting metal precursor [(p-cymene)Ru(μ-Cl)Cl]2 was prepared according to the published procedures and [Cp*MCl2]2 (M = Rh/Ir) were prepared using a synthesizer, Anton par mono-wave 50 [22].…”

Quantum Chemical and Experimental Studies of an Unprecedented Reaction Pathway of Nucleophilic Substitution of 2-Bromomethyl-1,3-thiaselenole with 1,3-Benzothiazole-2-thiol Proceeding Stepwise at Three Different Centers of Seleniranium Intermediates

“…1 H (400.1 MHz), 13 C (100.6 MHz), 15 N (40.56 MHz), and 77 Se (76.3 MHz) NMR spectra were recorded on a Bruker DPX-400 spectrometer (Bruker BioSpin GmbH, Rheinstetten, Germany) in 5%-10% solution in CDCl 3 referenced to HMDS ( 1 H−NMR, internal), the residual CDCl 3 peak (77.00 ppm for 13 C−NMR), MeNO 2 ( 15 N−NMR, external), and Me 2 Se ( 77 Se−NMR, external). Mass spectra were recorded on an Agilent 5975 Series Gas Chromatograph/Mass Selective Detector (GC/MSD) system (Agilent Technologies, Inc., Santa Clara, CA, USA) with electron impact (EI) ionization at 70 eV.…”

“…1 H−NMR (400 MHz, CDCl 3 ), δ: 7.04 (d, 3 J = 7.9 Hz, 2H, SCH=CHSe), 6.63 (d, 3 J = 7.9 Hz, 2H, SCH=CHSe), 6.42 (dd, 3 J cis = 9.8 Hz, 3 J trans = 16.4 Hz, 2H, H 2 C=CHS), 5.33 (d, 3 J cis = 9.8 Hz, 1H, H 2 C=CHS), 5.28 (d, 3 J trans = 16.4 Hz, 1H, H 2 C=CHS). 13 A solution of sodium 1,3-benzothiazole-2-thiolate (280 mg, 1.48 mmol) in acetonitrile (13 mL) was added to a solution of thiaselenole 1 (361 mg, 1.48 mmol) in acetonitrile (14 mL). The mixture was stirred at room temperature for 10 min.…”

“…Compounds containing a condensed thiazole ring, 2,3-dihydro [1,3]thiazolo [3,2-a]pyridines and [1,3]thiazolo [3,2-a]quinolines, show high antibacterial [5][6][7][8] and antitumor activity [9][10][11][12]. Platinum group metal complexes containing a benzothiazole moiety exhibit antibacterial [13] and antimicrobial [14] activity. Sulfur continues to maintain its status as the dominating heteroatom, integrated into a set of 362 sulfur-containing FDA-approved drugs [15].…”