Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Abstract

Benzhydrazone half-sandwich platinum group metal complexes were prepared by the reaction of metal precursors and benzhydrazone derivative ligands which yielded chelating N∩O and N∩N bidentate cationic complexes. Ruthenium complexes formed N∩O while rhodium and iridium complexes formed N∩N bonding modes respectively. Antibacterial activity (against Grampositive and Gram-negative bacteria) as well as anti-cancer (HCT116 p53 +/+ and HCT116 p53-/-) studies for these complexes were carried out.

In vitrobiological evaluation of half-sandwich platinum-group metal complexes containing benzothiazole moiety

“…This study confirms the formation of the in Table 2. The metal to chloride M(1)-Cl(1) and metal to nitrogen M(1)-N(1)/N(3) bond lengths found in these complexes are comparable to the previously reported values [32].…”

Synthesis, characterization, and anticancer activity of Ru(p-cymene) complexes bearing pyrazolyl–pyridine type ligands

“…Also, this method is relatively quick compared with other methods of evaluating antioxidant activities. [48][49][50][51] While Ru-bpy(1) fails to exhibit concentration-dependent antioxidant activity, Ru-pyn(2) displays constantly increasing radical scavenging activity at higher concentrations, such as 39.1 AE 1.5% at 30 mM, 43.8 AE 3.5% at 40 mM, and 67.5 AE 2.0% at 50 mM. Remarkably, Ru-pyn(2) shows nearly two-fold higher activity than Ru-bpy(1) at a 50 mM concentration.…”

Copper(II) and (η5-Cp*)rhodium(III) complexes of some imidazole and pyridine containing ligands

“…For example, the ( 5 -Cp*)Rh(III) complexes of some benzyhydrazone ligands (e.g. bzhyOH, Figure 1.12) have high cytotoxicity, and more importantly high selectivity towards HCT116 cancer cells [86]. The solution behaviours and anticancer activity of ( 5 -Cp*)Rh(III) complexes of several 8-hydroxyquinoline have been studied recently by Enyedy et al [87,88].…”