Half-dose vs one-third-dose photodynamic therapy for chronic central serous chorioretinopathy

Long-term results of half-dose photodynamic therapy for chronic central serous chorioretinopathy with contrast sensitivity changes

“…To find the safe, effective lowest dose, the effect of half-dose verteporfin was compared with one-third-dose verteporfin PDT, and half-dose PDT was observed to be more effective in the resolution of SRF for CCSC. 25 Prolonged detachment of the macula is known to lead to irreversible structural changes within the neurosensory retina, limiting the visual recovery Figure 2 The OCT image (a) shows SRF at diagnosis of acute CSC. The OCT image of same patients at 6th month (b) with granulation of the posterior surface of the detached retina (thick arrow) and granular deposits on RPE (thin arrow).…”

Photodynamic therapy for central serous chorioretinopathy

“…No complications were noted in the decreased-dose verterporfin group following PDT treatment. 17,19,21,22,29,35,47 Variation in Fluence: It is interesting to note that all of the studies with a variation in fluence had a recurrence of CSCR post PDT treatment within a 1-year-follow-up period. Recurrence rate of CSCR varied from 3 to 24%.…”

“…A similar pattern was noticed in Silva et al at 48 months with a reduction in CMT from 316 ± 114 to 169.7 ± 41.1 mm. 15,[17][18][19][20][21][22][23][24][25][26][27][29][30][31][33][34][35][36][37]46,47 Choroidal thickness on OCT Three studies assessed the choroidal thickness before and after PDT treatment (See Table 5 42 demonstrated that choroidal thickness in the area treated with PDT initially increased after treatment, then decreased. Pyrds and Larsen showed that choroidal thickness in the area where PDT was applied decreased from 407 mm (mean; 95% CI 356-458 mm) to 349 mm (mean; CI 95% 300-399 mm; Po0.0001), and subfoveal choroidal thickness was reduced from 421 mm (mean; CI 95% 352-489 mm) to 346 mm (mean; CI 95% 278-414 mm; P ¼ 0.0001).…”

“…Mean laser spot size ranged between 1300 and 6800mm. 15,[17][18][19][20][21][22][23][24][25][26][27][29][30][31][33][34][35][36][37]39,[41][42][43][44]46,47 Thirteen studies (n ¼ 13, 54.2%) used a mean spot size o4500 mm. The spot size was not mentioned in seven studies.…”

Central Serous Chorioretinopathy

“…Compared with laser photocoagulation, half-dose PDT may also facilitate an earlier resolution of macular detachment and the recovery of central retinal function [111]. One group studied even lower doses of verteporfin but obtained inferior results with one-third-dose PDT compared with half-dose PDT in terms of subretinal fluid resolution [112]. …”