Hairy-Cell Leukemia Complicating Coeliac Disease: Report of a Case and Discussion of Possible Pathogenetic Mechanisms

Abstract

10–28% of the patients with chronic coeliac disease develop a second malignancy, such as non-Hodgkin’s lymphomas, particularly of the histiocytic type, and adenocarcinomas. The second tumor may arise in the intestinal tract or in other organs. We describe here a patient who developed a tartrate-resistant, acid phosphatase-positive, hairy-cell leukemia after a history of chronic coeliac disease. In the literature, no similar case has been described as yet.

Celiac Disease with Acute Myeloid Leukemia: A Rare Association

“…Molitor et al [5] described a case of T cell large granular leukaemia in a 70 years old female, diagnosed with celiac disease 3 months prior. Re G et al [6] reported a case of hairy cell leukaemia after a history of celiac disease. Kline et al [7] reported a case of celiac disease that developed acute myeloid leukaemia 3 years after diagnosis of celiac disease.…”