A Reassessment of Splenic Hypofunction in Celiac Disease

Corazza, Gino Roberto; Zoli, Giorgio; Sabatino, Antonio Di; Ciccocioppo, Rachele; Gasbarrini, Giovanni

doi:10.1111/j.1572-0241.1999.00865.x

Cited by 61 publications

(36 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its use is complex, and interpreting the results is difficult, thus it will probably be difficult to implement counting PIT as a reliable method for diagnosing hyposplenia. There was no significant correlation between PIT and age, as described earlier [15] in HC nor in patient groups.…”

Section: Discussionmentioning

confidence: 63%

“…Red cells bearing vacuoles, so-called pits, can be visualized by interference contrast microscopy (DIC) as previously described [15]. Two drops of fresh heparinized blood were fixed in 2 mL 0.1% glutaraldehyde, pH 7.4.…”

Section: Methodsmentioning

confidence: 99%

“…In patients with homozygous sickle cell disease (HbSS), the function of the spleen is clearly diminished and a spectacular improvement in life expectancy has been observed following the introduction of a vaccination program and the administration of prophylactic antibiotics in children with HbSS [14]. In milder forms of compound SCD, such as HbSC and HbSb 1 thalassemia, as well as in celiac disease [15], Crohns'disease, and ulcerative colitis [16,17], the degree of splenic function impairment is less clear and the utility of the numerous research and clinical tests of spleen function lacks standardization.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyposplenism: Comparison of different methods for determining splenic function

et al. 2012

View full text Add to dashboard Cite

Asplenic patients are at risk for pneumococcal sepsis. Patients with hyposplenic function, such as associated with sickle cell disease (SCD), are also at risk. However, tests to assess splenic function are either unavailable or lacking standardization. The aim of this study was to compare different methods for determining splenic function. Eighteen patients with SCD (i.e., 10 heterozygous (SC) and 8 homozygous (SS) SCD patients), and eight splenectomized patients were compared to 10 controls. All subjects underwent spleen scintigraphy, after which functional splenic volumes (FSV) were calculated. FSV was compared to immunological function and B cell-subsets, as well as phagocytic function represented by the presence of Howell Jolly bodies (HJB) and percentages of pitted red cells (PIT). Heterozygous SCD (SC) patients had increased splenic volumes, but diminished FSV, homozygous SCD (SS) patients were asplenic. Splenectomized and SS patients had a strongly reduced phagocytic and immunological function. SC patients had reduced anti-polysaccharide responses without an increase in PIT. FSV correlated significantly with phagocytic and immunological function. HJB were indicative of splenic dysfunction, HJB absence was not indicative of normal functioning splenic tissue. Although visualizing HJB is methodologically advantageous to PIT, both are valid biomarkers of splenic dysfunction. The amount of non-switched memory B cells is strongly correlated to FSV. Am. J. Hematol. 87:484-489, 2012. V

show abstract

Section: Discussionmentioning

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hyposplenism: Comparison of different methods for determining splenic function

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Other investigators have reported an incidence of 30% to 60% in adults with CD. [108][109][110][111] Hyposplenism appears to be more common when CD coexists with other autoimmune disorders such as insulin-dependent diabetes mellitus, autoimmune thyroiditis, and connective-tissue disorders and when CD is complicated by lymphoma, refractory CD, or ulcerative jejunitis (59%-80%) than uncomplicated CD (19%), according to a recent report from Italy (Di Sabatino et al 112 ). O'Grady et al 113 studied 177 patients with CD using pitted-erythrocyte counts.…”

Section: Splenic Dysfunctionmentioning

confidence: 99%

Hematologic manifestations of celiac disease

Halfdanarson¹,

Litzow²,

Murray

2006

Blood

320

281

View full text Add to dashboard Cite

Celiac disease is a common systemic disorder that can have multiple hematologic manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematologic problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid, and/or vitamin B12 is a common complication of celiac disease and many patients have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism, and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis, but strict adherence to a gluten-free diet may prevent its occurrence.

show abstract

“…This molecule is a part of a specific carrier γG 1 cytophilic globulin which is cleaved by an enzyme through two steps, the first occurring in the spleen and the second on neutrophil granulocytes or monocytic-macrophagic cell membrane [2]. Tuftsin deficiency has been found in several diseases and is chiefly attributable to impaired splenic function [3,4,5,6,7,8,9]. Such a defect may participate to development of the increased susceptibility to bacterial infections of these conditions.…”

Section: Introductionmentioning

confidence: 99%

Effect of Liver Transplantation on Tuftsin Activity and Phagocytic Activity of Neutrophil Granulocytes in Patients with Liver Cirrhosis

Foschi

Trevisani

Loggi

et al. 2005

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Tuftsin activity (TA) is reduced in cirrhosis. This contributes to the defective phagocytic activity (PA) of neutrophil granulocytes and is related to the impairment of splenic function. Orthotopic liver transplantation (OLT) cures cirrhosis and might restore TA. This study was aimed at determining if OLT restores TA and PA. Methods: We measured in 9 cirrhotic patients, before and after successful OLT, TA by a bioassay and PA by chemiluminescence in which neutrophils of the patient were tested with both autologous (PA1) and pooled sera from healthy subjects (PA2). Splenic function was assayed by the pitted red cell count. Results: Before OLT, TA was reduced in 7 patients, and PA1 in all the patients. Pitted cell count was elevated in all the patients. After OLT (median 39 months; range 21–49), TA improved in all cases [median: from 8% (5–16%) to 20% (9–22%), p < 0.008], normalizing in 5 out of the 7 patients with low values. PA1 improved in all the patients [from 102 cpm (65–128 cpm) to 235 cpm (78–280 cpm), p < 0.008], normalizing in 5. Pitted red count decreased in 7 patients and normalized in 3 [from 3.3% (2.1–6.0%) to 2.4% (1.4–2.8%), p < 0.021]. Platelet count [from 55 × 10³ (30–100) to 185 × 10³ (93–286), p < 0.008] and leucocyte count [from 3.60 × 10³ (1.81–5.23) to 5.53 × 10³ (3.31–6.71), p < 0.008] also improved. Conclusions: OLT improves TA and PA of cirrhotic patients. This effect is associated with an improvement of both functional hyposplenism and haematological hypersplenism. The restoration of natural defences against infections may mitigate the adverse effect of immunosuppressive treatment.

show abstract

A Reassessment of Splenic Hypofunction in Celiac Disease

Cited by 61 publications

References 33 publications

Hyposplenism: Comparison of different methods for determining splenic function

Hyposplenism: Comparison of different methods for determining splenic function

Hematologic manifestations of celiac disease

Effect of Liver Transplantation on Tuftsin Activity and Phagocytic Activity of Neutrophil Granulocytes in Patients with Liver Cirrhosis

Contact Info

Product

Resources

About