Hairpin-shaped tetranuclear palladium(II) complex: Synthesis, crystal structure, DNA binding and cytotoxicity activity studies

Gao, Enjun; Wang, Kehua; Zhu, Mingchang; Liu, Lei

doi:10.1016/j.ejmech.2010.02.061

Cited by 41 publications

(12 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Actually, EB had no perceptible emission in buffer solution; after adding DNA, the fluorescence intensity improved obviously, which was considered of its strongly intercalation with DNA base pairs. The intercalation of the compound with the base pairs of DNA can be confirmed when the DNA À EB emission can be decreased or quenched upon adding a compound (Li et al, 1996;Gao et al, 2010). As expected, the emission intensity apparently reduced (shown in Figure 5) by adding L 1 and L 3 to DNA-EB, which exhibits that L 1 and L 3 can bind to DNA at the sites occupied by EB, and it can interact with DNA by intercalation.…”

Section: Dna Binding Modessupporting

confidence: 63%

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

Zhao

Sun

et al. 2020

Drug Delivery

View full text Add to dashboard Cite

Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiffbases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix), MCF-7 (breast), A549 (lung), HepG2 (liver), and HUVEC (umbilical vein) cells by MTT assay. The toxicity of L 1 ÀL 10 (IC 50 ¼ 5.92À >100 lM) was lower than L 0 (1.27 lM) and DOX (4.40 lM) in every case. Compound L 1 had higher anti-HepG2 (0.66 lM), anti-MCF-7 (5.33 lM), and anti-A549 (2.11 lM) and compound L 3 had higher anti-HepG2 (1.63 lM) and anti-MCF-7 (2.65 lM) activities. Both of these compounds were recognized with high efficiency in apoptosis induction in HepG2 cells and intercalated binding modes with DNA. Moreover, with average IC 50 values of 0.66 and 5.98 lM, L 1 was nine times more effective at suppressing cultured HepG2 cells viability than normal cells (SI ¼ 9). The relative tumor proliferation rate (T/C) was 38.6%, the tumor inhibition rate was up to 61.2%, which indicated that L 1 had no significant toxicity but high anti-HepG2 activity in vivo. Thus, it may be a potential antiproliferation drug with nontoxic side effects.

show abstract

Section: Dna Binding Modessupporting

confidence: 63%

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

Zhao

Sun

et al. 2020

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…67 There are also reports on palladium derivatives interacting with DNA in covalent 68,69 and non-covalent fashions. 70,71 Conversely, most gold-based compounds do not display a strong interaction with DNA. 10,11 …”

Section: Resultsmentioning

confidence: 99%

Potential Anticancer Heterometallic Fe–Au and Fe–Pd Agents: Initial Mechanistic Insights

et al. 2013

View full text Add to dashboard Cite

A series of gold(III) and palladium(II) heterometallic complexes with new iminophosphorane ligands derived from ferrocenyl-phosphanes [{Cp-P(Ph2)=N-Ph}2Fe] (1), [{Cp-P(Ph2)=N-CH2-2-NC5H4}2Fe] (2) and [{Cp-P(Ph2)=N-CH2-2-NC5H4}Fe(Cp)] (3) have been synthesized and structurally characterized. Ligands 2 and 3 afford stable coordination complexes [AuCl2(3)]ClO4, [{AuCl2}2(2)](ClO4)2, [PdCl2(3)] and [{PdCl2}2(2)]. The complexes have been evaluated for their antripoliferative properties in human ovarian cancer cells sensitive and resistant to cisplatin (A2780S/R), in human breast cancer cells (MCF7) and in a non-tumorigenic human embryonic kidney cell line (HEK-293T). The highly cytotoxic trimetallic derivatives M2Fe (M = Au, Pd) are more cytotoxic to cancer cells than their corresponding monometallic fragments. Moreover, these complexes were significantly more cytotoxic than cisplatin in the resistant A2780R and the MCF7 cell lines. Studies of the interactions of the trimetallic compounds with DNA and the zinc-finger protein PARP-1 indicate that they exert anticancer effects in vitro based on different mechanisms of actions with respect to cisplatin.

show abstract

“…46 There are also reports on palladium derivatives interacting with DNA in covalent 47,48 and non-covalent ways. 49,50 Conversely, most gold-based compounds do not display strong interaction with DNA. 10,11 Thus, we performed agarose gel electrophoresis studies to unravel the effects of the new compounds 2 – 7 on plasmid (pBR322) DNA (Fig.…”

Section: Resultsmentioning

confidence: 99%

Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents

Frik

Jiménez

Vasilevski

et al. 2014

Inorg. Chem. Front.

View full text Add to dashboard Cite

A series of coordination gold(III), palladium(II), and platinum(II) complexes with a luminescent iminophosphorane ligand derived from 8-aminoquinoline [Ph3P=N-C9H6N] (1), have been synthesized and structurally characterized. The coordination palladium(II) and platinum(II) compounds can evolve further, under appropriate conditions, to give stable cyclometalated endo species [M{κ3-C,N,N-C6H4(PPh2=N-8-C9H6N}Cl] (M = Pd, Pt) by C-H activation of the phenyl group of the PPh 3 fragment. Iminophosphorane 1 and the new metallic complexes are luminescent in DMSO or DMSO:H2O (1:1 mixture) solutions at RT. The compounds have been evaluated for their antiproliferative properties in a human ovarian cancer cell line (A2780S), in human lung cancer cells (A-549) and in a non-tumorigenic human embryonic kidney cell line (HEK-293T). Most compounds have been more toxic to the ovarian cancer cell line than to the non-tumorigenic cell line. The new complexes interact with human serum albumin (HSA) faster than cisplatin. Studies of the interactions of the compounds with DNA indicate that, in some cases, they exert anticancer effects in vitro based on different mechanisms of action with respect to cisplatin.

show abstract

Hairpin-shaped tetranuclear palladium(II) complex: Synthesis, crystal structure, DNA binding and cytotoxicity activity studies

Cited by 41 publications

References 47 publications

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

Potential Anticancer Heterometallic Fe–Au and Fe–Pd Agents: Initial Mechanistic Insights

Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents

Contact Info

Product

Resources

About