Hair loss at injection sites of mesotherapy for alopecia

Abstract

Mesotherapy for androgenetic alopecia may paradoxically induce hair loss and scarring. Proper regulation and monitoring of the use of mesotherapy products for treating hair loss in women, needs to be addressed.

Mesotherapy: Safety profile and management of complications

“…In such a case presented by Kadry et al, the conservative treatment seemed to show no effect; so the surgical removal of the inflamed tissues was selected as the treatment of choice . El‐Komy et al describe a series of three patients, where the prominent histologic feature was not an inflammation of the fat tissue, but rather an inflammatory scarring process with perivascular and perifollicular lymphohistiocytic infiltration and sebaceous gland hyperplasia, as well as a hypertrophy of the perifollicular collagen fibers . The mesotherapy cocktail used in two out of the three cases included dutasteride 0.005% (Mesologica ® ), insulin‐like growth factor‐1 (IGF‐1), basic fibroblast growth factor (bfGf), vascular endothelial growth factor (VEGF), copper tripeptide‐1, multi‐vitamins, amino acids, and minerals (Mesologica MRS Hair ® ) .…”

“…El‐Komy et al describe a series of three patients, where the prominent histologic feature was not an inflammation of the fat tissue, but rather an inflammatory scarring process with perivascular and perifollicular lymphohistiocytic infiltration and sebaceous gland hyperplasia, as well as a hypertrophy of the perifollicular collagen fibers . The mesotherapy cocktail used in two out of the three cases included dutasteride 0.005% (Mesologica ® ), insulin‐like growth factor‐1 (IGF‐1), basic fibroblast growth factor (bfGf), vascular endothelial growth factor (VEGF), copper tripeptide‐1, multi‐vitamins, amino acids, and minerals (Mesologica MRS Hair ® ) . The management of this adverse reaction included the prescription of topical minoxidil or the application of intralesional saline injections twice daily at the affected area, combined with a topical melatonin solution .…”

“…The mesotherapy cocktail used in two out of the three cases included dutasteride 0.005% (Mesologica ® ), insulin‐like growth factor‐1 (IGF‐1), basic fibroblast growth factor (bfGf), vascular endothelial growth factor (VEGF), copper tripeptide‐1, multi‐vitamins, amino acids, and minerals (Mesologica MRS Hair ® ) . The management of this adverse reaction included the prescription of topical minoxidil or the application of intralesional saline injections twice daily at the affected area, combined with a topical melatonin solution . Cases of noncicatrical alopecia, as an acute side‐effect of mesotherapy, have also been described .…”

“…34 The management of this adverse reaction included the prescription of topical minoxidil or the application of intralesional saline injections twice daily at the affected area, combined with a topical melatonin solution. 34 Cases of noncicatrical alopecia, as an acute side-effect of mesotherapy, have also been described. 35,36 The main histopathologic features here are absent terminal anagen hair follicles, and increased numbers of telogen and catagen follicular units, as observed in the cases of anagen effluvium.…”

Androgenic alopecia and dutasteride in hair mesotherapy: A short review

“…Some studies reported patchy hair loss [54] and cicatricial alopecia [55] after the injections. Multifocal scalp abscesses with fat necrosis was also reported [56].…”