Hair growth stimulation by a Natural Remedy: Animal Studies

Abstract

Hair follicles normally regenerate cyclically and this makes them a popular model for investigations of regeneration and aging. We studied the effects on mouse hair follicles of the Satura ® Rosta remedy manufactured from plant extracts and used to stimulate hair growth restoration. A prolonged application of the remedy to the skin of various strains of mice and of outbred white mice did not induce detectable negative effects and caused a significant increase of mean hair follicle size and hair root volume as well as skin thickening due to adipose elaboration. The volume increase took place mainly among the largest hair follicles. Mouse skin thickness is known to fluctuate cyclically in coordination with the waves of hair growth; anagen regions are thicker due to adipose increase. Satura ® Rosta did not abrogate hair growth waves. Apparently the observed effects could be explained by the remedy-induced prolongation of the anagen phase. Although the effect of Satura ® Rosta on fur appearance was insignificant in young animals, experiments with old mice exhibiting alopecia resulted in hair regrowth in alopecia regions. Transcriptome analysis of Satura ® Rosta action on dermal fibroblasts in vitro revealed significant changes of the expression of genes associated with the cell cycle, developmental processes and lipid metabolism.

PLANT ANTIOXIDANTS AND THEIR NON-TRADITIONAL SOURCES (review)

“…В частности, полифенольные соединения продемонстрировали способность модулировать состав и функцию микроорганизмов в ЖКТ, влияя на проницаемость мембран, а также повышая чувствительность бактерий к ксенобиотикам. При изменении состава пищевых ингредиентов состав микробиоты меняется в течение 24 ч, что влияет на функциональное состояние организма и его устойчивость к факторам среды (67,68).…”