Hair Cortisol Measurement by an Automated Method

González, Diego; Jacobsen, Darío; Ibar, Carolina; Paván, Carlos Humberto; Monti, José Luis; Machulsky, Nahuel Fernandez; Balbi, Ayelen; Fritzler, Analy; Jamardo, Juan; Repetto, Esteban Martín; Berg, Gabriela; Fabre, Bibiana

doi:10.1038/s41598-019-44693-3

Cited by 42 publications

(38 citation statements)

References 24 publications

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“…The concentration values obtained in this study were low in comparison with modern dentine data (Nejad et al, 2016), archaeological hair concentrations (Webb et al, 2015a), and modern standards from hair, saliva, blood, and urine (Aardal & Holm, 1995;Deutschbein et al, 2011;Gonzalez et al, 2019). Not all of the samples in this analysis met the minimum detection threshold of the ELISA cortisol kits.…”

Section: Low Concentrations Detectedcontrasting

confidence: 73%

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Quade

Chazot

Gowland

2020

American J Phys Anthropol

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Objectives: Cortisol is a glucocorticoid hormone produced through activation of the hypothalamic pituitary adrenal axis. It is known as the "stress hormone" for its primary role in the body's stress response and has been the focus of much modern clinical research. Within archaeology, only a few studies have analyzed cortisol in human remains and these have been restricted to hair (Webb et al., 2010; Webb, White, van Uum, & Longstaffe, 2015a; Webb, White, van Uum, & Longstaffe, 2015b). This study examines the utility of dentine and enamel, which survive well archaeologically, as possible reservoirs for detectable levels of cortisol. Materials and methods: Then, 69 teeth from 65 individuals from five Roman and Post-Roman sites in France were tested via competitive enzyme-linked immunosorbent assay (ELISA) to assess and quantify the cortisol concentrations present within tooth dentine and enamel. Results: In both tooth dentine and enamel, detectable concentrations of cortisol were identified in multiple teeth. However, concentrations were low and not all teeth yielded results that were measurable through cortisol ELISA. Differences in cortisol values between dentine and enamel could suggest different uptake mechanisms or timing. Discussion: These results suggest that cortisol is incorporated within tooth structures and merits further investigation in both modern and archaeological contexts. Analysis of the results through liquid chromatographic-mass spectrometry would verify current results and might yield values that could be better integrated with published cortisol studies. Future studies of cortisol in tooth structures would greatly expand the research potential of cortisol in the past and could have implications for studies of human stress across deep time.

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Section: Low Concentrations Detectedcontrasting

confidence: 73%

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Quade

Chazot

Gowland

2020

American J Phys Anthropol

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“…Third, the majority of participants (70%) have had some hair treatment, and the differences in frequency of hair washing between participants were not measured. At this point, the importance of these factors is not clear, as the majority of studies have found null effects or only small effects regarding hair treatment and/or hair washing ( Gonzalez et al, 2019 , Stalder et al, 2017 ). Other limitations include the use of self-administered questionnaires, the data from which could be biased.…”

Section: Discussionmentioning

confidence: 99%

Stress and hair cortisol concentrations in nurses during the first wave of the COVID-19 pandemic

Rajčáni

Vytykačová

Soláriková

et al. 2021

Psychoneuroendocrinology

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“…One reference range reported for cortisol in hair is 17.7–153.2 pg/mg of hair (median 46.1 pg/mg) [ 63 ]. A more recent study [ 64 ] reported a hair cortisol concentration reference interval in healthy individuals with low levels of stress to be 40–128 pg/mg of hair while the range for concentrations in stressed individuals was higher (182–520 pg/mg of hair). Hair specimens in our sample were obtained from 44 respondents, mostly because respondents did not have enough hair to provide a sample.…”

Section: Methodsmentioning

confidence: 99%

Psychological and physiological stress and burnout among maternity providers in a rural county in Kenya: individual and situational predictors

et al. 2021

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Background Stress and burnout among healthcare workers has been recognized as a global crisis needing urgent attention. Yet few studies have examined stress and burnout among healthcare providers in sub-Saharan Africa, and even fewer among maternity providers who work under very stressful conditions. To address these gaps, we examined self-reported stress and burnout levels as well as stress-related physiologic measures of these providers, along with their potential predictors. Methods Participants included 101 maternity providers (62 nurses/midwives, 16 clinical officers/doctors, and 23 support staff) in western Kenya. Respondents completed Cohen’s Perceived Stress Scale, the Shirom-Melamed Burnout scale, and other sociodemographic, health, and work-related items. We also collected data on heart rate variability (HRV) and hair cortisol levels to assess stress-related physiologic responses to acute and chronic stress respectively. Multilevel linear regression models were computed to examine individual and work-related factors associated with stress, burnout, HRV, and cortisol level. Results 85% of providers reported moderate stress and 11.5% high stress. 65% experienced low burnout and 19.6% high burnout. Average HRV (measured as the root mean square of differences in intervals between successive heart beats: RMSSD) was 60.5 (SD = 33.0) and mean cortisol was mean cortisol was 44.2 pg/mg (SD = 60.88). Greater satisfaction with life accomplishments was associated with reduced stress (β = − 2.83; CI = -5.47; − 0.18), while motivation to work excessively (over commitment) was associated with both increased stress (β = 0.61 CI: 0.19, 1.03) and burnout (β = 2.05, CI = 0.91, 3.19). Female providers had higher burnout scores compared to male providers. Support staff had higher HRV than other providers and providers under 30 years of age had higher HRV than those 30 and above. Although no association between cortisol and any predictor was statistically significant, the direction of associations was consistent with those found for stress and burnout. Conclusions Most providers experienced moderate to high levels of stress and burnout. Individuals who were more driven to work excessively were particularly at risk for higher stress and burnout. Higher HRV of support staff and providers under age 30 suggest their more adaptive autonomic nervous system response to stress. Given its impact on provider wellbeing and quality of care, interventions to help providers manage stress are critical.

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Hair Cortisol Measurement by an Automated Method

Cited by 42 publications

References 24 publications

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Stress and hair cortisol concentrations in nurses during the first wave of the COVID-19 pandemic

Psychological and physiological stress and burnout among maternity providers in a rural county in Kenya: individual and situational predictors

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