Hair cell regeneration: An exciting phenomenon . . . But will restoring hearing and balance be possible?

Matsui, Jonathan I.; Ryals, Brenda M.

doi:10.1682/jrrd.2005.01.0008

Cited by 23 publications

(15 citation statements)

References 114 publications

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“…In contrast, lost HCs are not normally replaced in the traumatized mammalian cochlea (Holley, 2005;Matsui and Ryals, 2005). However, there is a small but significant spontaneous renewal of HCs occurring in the vestibular sensory epithelia of several mammalian species, as demonstrated in vivo for guinea pig and chinchilla and in vitro for rat after ototoxic injury (Forge et al, 1993;Tanyeri et al, 1995;Berggren et al, 2003;Cunningham and Brandon, 2006).…”

Section: Introductionmentioning

confidence: 99%

Morphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Morphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants

et al. 2012

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“…If so, this could have masked any differential hearing loss in musicians in this study. There is also well-established evidence that some individuals may have a greater genetic susceptibility to hearing loss [9,10]. The findings may represent an element of a healthyworker effect.…”

Section: Discussionmentioning

confidence: 98%

Hearing loss in British Army musicians

Patil¹,

Sadhra

Taylor

et al. 2013

Occupational Medicine

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Background Military musicians increasingly fulfil front line roles. Existing literature suggests that musicians are at greater risk of hearing loss than the general population. It is important to ascertain whether these findings apply to military musicians if they are to be placed in operational acoustically hazardous environments. AimsTo compare hearing loss between groups of British Army musicians and with their administrative (non-musician) counterparts. MethodsRoutine health surveillance audiometric data for a group of military musicians were compared with military administrative staff during the first 8-12 years of their careers. Structured interviews were used to identify those meeting the study inclusion criteria (8 year minimum service, no significant, relevant medical history, no previous extraordinary loud noise exposure, service within study employment group throughout military career), and to clarify the instrument played. ResultsEighty-four musicians and 44 administrators participated. Using the Health & Safety Executive's (HSE's) age-and gender-correcting system, 12 (14%) musicians and 9 (20%) non-musicians had a deterioration in hearing. The overall odds ratio for developing hearing loss in musicians was 0.65 (95% CI 0.25-1.68). Compared with woodwind instrumentalists, the odds ratio for hearing loss in brass instrumentalists was 2.00 (95% CI 0.85-3.44) and for percussionists 1.83 (95% CI 0.77-2.90). ConclusionsThe findings suggest that military musicians are at no greater risk of hearing loss than their administrative counterparts after 8-12 years in service. This may represent a healthy-worker effect. There is no statistically significant differential risk of hearing loss between different instrumental groups.

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“…In addition, pDCs express tolerogenic phenotype and induce Treg cell through the expression of IDO [61][62][63][64]. In vivo study further showed that selective ablation of DCs led to the loss of FoxP3-expressing Treg and the development of proinflammatory autoreactive T effectors, resulting in excessive autoimmunity [65].…”

Section: Effect Of Toldcs On Regulatory T Cells (Treg)mentioning

confidence: 99%

Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives

Zhao

Zhang

et al. 2011

Rheumatol Int

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the influxation of synovia and synovial compartments with immune cells including dendritic cells (DCs). DCs that induce autoimmune tolerance are called tolerogenic DCs (tolDCs). As a promising immunotherapeutic strategy for RA, tolDCs have received increasing attention. In this review, we first introduce the significant role of tolDCs in autoimmune regulation and then describe the manipulation strategies to generate tolDCs; next, we summarize recent progress in the experimental application of tolDCs for RA therapy, and finally we discuss the perspectives of tolerogenic vaccination for the treatment for RA in clinic.

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Hair cell regeneration: An exciting phenomenon . . . But will restoring hearing and balance be possible?

Cited by 23 publications

References 114 publications

Morphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants

Morphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants

Hearing loss in British Army musicians

Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives

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