Hair as a biopsy material: trace element data on one man over two decades

Klevay, Leslie M.; Christopherson, D.M.; Shuler, Terrence R.

doi:10.1038/sj.ejcn.1601975

Cited by 33 publications

(19 citation statements)

References 39 publications

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“…Hac et al (2002) describe a significant correlation between the measured values of plasma and hair Se. Similarly, Klevay et al (2004) show a conclusive ratio between Se in hair and in the tissues of kidneys, liver and lungs. It is also described in humans that the content of Zn in hair correlates remarkably well with its concentration in other tissues, such as bones and testicles (Klevay et al, 2004).…”

mentioning

confidence: 85%

“…Similarly, Klevay et al (2004) show a conclusive ratio between Se in hair and in the tissues of kidneys, liver and lungs. It is also described in humans that the content of Zn in hair correlates remarkably well with its concentration in other tissues, such as bones and testicles (Klevay et al, 2004). Lowe et al (2009) summarised 49 recent studies in humans and compared the suitability of 32 biomarkers of Zn status.…”

mentioning

confidence: 85%

“…This is in spite of the fact that in humans the determination of microelements in hair is considered as promising (Lowe et al, 2009). Klevay et al (2004), for example, state that the Zn content in hair correlates remarkably with its concentration in other tissues. The determination of concentration in blood elements has a lower informative value.…”

Section: Zinc Supplementation Experimentsmentioning

confidence: 99%

“…This is why hair has potentially great importance in identifying the mineral status in individual animals (Combs, 1987;Perrone et al, 1996). A potential problem in hair analysis is insufficient standardisation of results but with the application of good modern laboratory practice and validated methodology it is possible to obtain reliable results (Bass et al, 2001;Klevay et al, 2004).…”

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confidence: 99%

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Impact of long-term supplementation of zinc and selenium on their content in blood and hair in goats

Pavlata¹,

Chomat²,

Pechová³

et al. 2011

Vet. Med. - Czech

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This paper evaluates the impact of long-term supplementation of different forms of zinc (Zn) and selenium (Se) on the content of these substances in the blood and hair of goats. Two analogous supplementation experiments were performed. 37 goats divided into four groups were used in the first trial with the Zn supplementation. Group A (n = 10) was a control group (with no Zn administered). A further three groups (B, C, D) were supplemented with Zn in various forms. Group B (n = 9) with zinc oxide, Group C (n = 9) with zinc lactate and Group D (n = 9) with zinc chelate. The second trial with Se supplementation was carried out on 20 goats divided into four groups. Group E (n = 5) was a control group. The other three groups were administered Se. Group F (n = 5) was supplied with a selenium lactate-protein complex, Group G (n = 5) with sodium selenite and Group H (n = 5) with selenium yeast. Three months later blood and hair samples were taken from all animals and Zn and Se concentrations were determined in whole blood, plasma, and hair. Glutathione peroxidase (GSH-Px) activity was determined in the Se supplementation trial group. At the end of the trial the Zn concentrations in plasma and whole blood were without major differences between the groups. The plasma concentration of Zn did not increase from the initial value at the start of the trial. In hair the average concentration of Zn was 95.2-100.0 mg/kg in all groups. No conclusive relation was confirmed between the values of Zn in hair and its concentration in blood. The Se concentration in whole blood (µg/l) at the end of trial in supplemented groups (F -188.8 ± 24.6; G -197.2 ± 10.9; H -190.1 ± 26.3) was significantly higher (P < 0.01) than in the control group (E -103.1 ± 23.5). Similarly, the activity of GSH-Px (µkat/l) was significantly higher in all supplemented groups (F -872.3 ± 94.8; G -659.5 ± 176.4; H -839.8 ± 150.8) than in the control group (E -379.1 ± 63.5). Se content in hair (µg/kg) was higher also in all trial groups (F -242.3 ± 41.5; G -200.5 ± 46.9; H -270.0 ± 106.8) than in the control group (E -174.7 ± 38.0). However, it was significantly (P < 0.05) higher only in Group F. A conclusive correlation was identified between the Se concentration in whole blood and its content in hair (r = 0.54; P < 0.05; n = 20). Based on the results it can be concluded that none of the supplemented forms of Zn increased its concentration in blood, plasma and hair. On the other hand, the administration of Se led to an increase in the Se concentration in blood, increased the activity of GSH-Px in whole blood and the Se content in hair. Based on the proven correlation and regression relation between the Se concentration in blood and its content in hair, hair can be considered as a suitable material for the diagnosis of long-term Se status in goats. Goats with sufficient Se status are those that have more than 160 µg/kg of Se in hair dry weight.

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mentioning

confidence: 85%

mentioning

confidence: 85%

Section: Zinc Supplementation Experimentsmentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of long-term supplementation of zinc and selenium on their content in blood and hair in goats

Pavlata¹,

Chomat²,

Pechová³

et al. 2011

Vet. Med. - Czech

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“…Based on our results, the concentration of zinc was affected only by the animal species. On the basis of studied literature (Scott 1991;Ikemoto et al 2004;Klevay et al 2004) we suggest that zinc concentration in hair is influenced by the concentration of this element in the body.…”

Section: Coppermentioning

confidence: 83%

The evaluation of Cu, Zn, Mn, and Se concentrations in the hair of South American camelids

Holasová

Pechová

Husáková³

2017

Acta Vet. Brno

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The aim of this study was to monitor the content of trace elements in the hair of South American camelids and to evaluate the effect of coat colour, species, age, and sex on their concentration in the hair. The samples were collected from 77 animals -23 llamas (Llama guanicoe f. gllama) and 54 alpacas (Llama guanicoe f. pacos) during a spring health check. The concentrations of copper (Cu), zinc (Zn), and manganese (Mn) were determined by Flame Atomic Absorption Spectrometry and selenium (Se) by Hydride Generation Atomic Absorption Spectrometry. We found the following concentrations (mean ± standard deviation; mg/kg dry matter) in the llama hair: Cu 9.70 ± 4.69; Zn 145.20 ± 21.07; Mn 12.49 ± 10.14; Se 0.25 ± 0.14. In alpaca hair we found the following concentrations: Cu 10.22 ± 2.90; Zn 129.81 ± 19.01; Mn 12.67 ± 13.85; Se 0.48 ± 0.24. We found a significant difference between llamas and alpacas in Zn and Se concentrations in the hair. From all the evaluated factors we found that coat colour had the highest effect on Mn and Se concentration. Dark haired animals had significantly higher concentrations of these trace elements than other coloured groups. The evaluation of the concentration of trace elements in the hair of llamas has a potential to be used for the evaluation of long-term status of trace elements in the body; however, it is necessary to continue with experimental work in this area. Our findings can serve as a pilot study for further works in this field.

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Correlation between Congenital Heart Defects and maternal copper and zinc concentrations

Liu

et al. 2014

Birth Defects Research

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Hair as a biopsy material: trace element data on one man over two decades

Cited by 33 publications

References 39 publications

Impact of long-term supplementation of zinc and selenium on their content in blood and hair in goats

Impact of long-term supplementation of zinc and selenium on their content in blood and hair in goats

The evaluation of Cu, Zn, Mn, and Se concentrations in the hair of South American camelids

Correlation between Congenital Heart Defects and maternal copper and zinc concentrations

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