Correlation between Congenital Heart Defects and maternal copper and zinc concentrations

Hu, Hui; Liu, Zhen; Li, Jun; Li, Shengli; Tian, Xiaoling; Lin, Yuan; Chen, Xinlin; Yang, Jiaxiang; Deng, Ying; Li, Nana; Wang, Yanping; Yuan, Ping; Li, Xiaohong; Zhu, Jun

doi:10.1002/bdra.23284

Cited by 23 publications

(34 citation statements)

References 34 publications

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“…Hair lead was also found to be dose dependently associated with the presence of certain sub-types of congenital heart defects in a Chinese case control study [ 56 ]. Additionally, hair copper was associated with total CHDs, but particularly conotruncal defects [ 57 ], hair aluminum was associated with total CHDs and particularly septal and conotruncal defects and right ventricular outflow tract obstruction [ 58 ], and hair barium was associated with total CHDs and particularly with septal defects, conotruncal defects, right and left ventricular outflow tract obstruction and anomalous pulmonary venous return [ 59 ]. Only one study has assessed maternal blood metals and found that high blood lead was associated with total CHDs, conotruncal defects, septal defects and right ventricular outflow tract obstruction, while higher blood selenium was protective; cadmium, chromium, copper and mercury were not associated their own but may have had an interactive effect [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Nicoll

2018

IJERPH

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Congenital heart defects (CHDs) are a common birth defect of largely unknown etiology, with high fetal and neonatal mortality. A review of CHDs and environmental contaminant exposure found that meta-analyses showed only modest associations for smoking, vehicle exhaust components, disinfectant by-products and proximity to incinerators, with stronger results from the newer, larger and better quality studies masked by the typical absence of effect in older studies. Recent studies of exposure to agricultural pesticides, solvents, metals and landfill sites also showed associations. Certain contaminants have been associated with certain CHDs, with septal defects being the most common. Frequent methodological problems include failure to account for potential confounders or maternal/paternal preconception exposure, differences in diagnosing, defining and classifying CHDs, grouping of defects to increase power, grouping of contaminants with dissimilar mechanisms, exclusion of pregnancies that result in death or later life diagnosis, and the assumption that maternal residence at birth is the same as at conception. Furthermore, most studies use measurement estimates of one exposure, ignoring the many additional contaminant exposures in daily life. All these problems can distort and underestimate the true associations. Impaired methylation is a common mechanism, suggesting that supplementary folate may be protective for any birth defect.

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Section: Resultsmentioning

confidence: 99%

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Nicoll

2018

IJERPH

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“…For instance, one study reports that maternal periconceptional intake of vitamin E is associated with congenital heart defects (CHDs), while another study reports that Vitamin E intake during pregnancy does not carry any risk of birth abnormalities . Also, it has been reported that women with excessive serum copper concentrations have a significantly increased risk of having offspring with a CHD, whereas, a low maternal zinc status might have a correlation with CHD . In a similar report, it was stated that within the normal range of maternal serum zinc and copper concentrations, there is no variation in risk of neural tube defects but women with very high serum zinc levels may have an increased risk of neural tube defects .…”

Section: Discussionmentioning

confidence: 99%

“…30 Also, it has been reported that women with excessive serum copper concentrations have a significantly increased risk of having offspring with a CHD, whereas, a low maternal zinc status might have a correlation with CHD. 31 In a similar report, it was stated that within the normal range of maternal serum zinc and copper concentrations, there is no variation in risk of neural tube defects but women with very high serum zinc levels may have an increased risk of neural tube defects. 32 Further, a case-control study provides evidence that suggests an association between concentrations of maternal zinc and the risk of orofacial clefts in offspring.…”

Section: The Impact Of Low Iron Intake During Pregnancy and Poor Compmentioning

confidence: 99%

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Offor

Awodele

Oshikoya

2019

Pharmacology Res & Perspec

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Birth defects are important causes of neonatal morbidity and mortality. A good understanding of the etiology is a vital step toward developing improved treatment and preventive strategies. We conducted an audit of medical records of newborns with birth abnormalities in a tertiary hospital over a 10‐year period, using a Pro forma designed to collect information on obstetric history, antenatal history, sociodemographics of parents, and the type of birth abnormality. Of the 180 medical records reviewed, female babies were 92 (51.1%) and male babies were 86 (47.8%). The mean age of the fathers was 38.2 + 6.2, and mothers 31.8 + 4.9. Majority 115 (63.9%) of the mothers had records of acute illnesses, and 23 (12.8%) chronic illnesses during pregnancy. Unspecified febrile illness 44 (38.3%), malaria 40 (34.8%), typhoid 8 (6.9%), hypertension 13 (56.5%), pregestational diabetes 4 (17.4%), and HIV 3 (13.0%) were the commonest maternal pathologies. Most of the documented birth abnormalities were Down's syndrome 34 (15.2%); congenital hydrocephalus 32 (14.3%); acyanotic congenital heart defect 30 (13.4%); deformity of the digits 26 (11.6%); and ventricular septal defect 20 (8.9%). The prevalence of maternal pathologies calls for concern, as these may be implicated in birth defects, therefore should be further investigated in future studies.

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“…Each donor signed a patient consent form. The database utilized in the present study has been previously used to explore the relationship between pregnant women exposure to lead and copper in the first three months of pregnancy and risk of CHD in their offspring …”

Section: Methodsmentioning

confidence: 99%

“…The causes of the remaining cases are not well understood but are assumed to be caused by the effects of multiple genes in combination with environmental factors. 2 Increased risk of CHD has been reported with higher maternal blood levels of lead 3 and copper, 4 and lower maternal intake of folate. 5 Selenium (Se) is an essential element in the human body that is required for antioxidant enzyme activities.…”

Section: Introductionmentioning

confidence: 99%

High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring

Guo

Zhu

et al. 2019

Prenatal Diagnosis

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Objective To examine whether maternal hair or cord blood selenium levels are associated with infant congenital heart defects (CHDs). Method A hospital‐based case‐control study was performed with samples collected from 2010 to 2014. Selenium levels in maternal hair and fetal cord serum were measured using Inductively Coupled Plasma‐Mass Spectrometry (ICP‐MS). Data from medical records of infants with CHDs were collected. Logistic regression analysis was employed to examine the independent association between maternal selenium exposure and fetal CHD. Results In total, 888 pregnant women were included in this study. Median (interquartile range) selenium levels in of maternal hair was similar in the control and CHD group. A significant association was detected between increased maternal hair selenium concentration and CHDs in offspring (adjusted odds ratio [aOR] 3.57, 95 %CI, 1.90‐6.70). The association was present in all CHD groups, including septal defects, conotruncal defects, left ventricular outflow tract obstruction, right ventricular outflow tract obstruction, and anomalous pulmonary venous return. Conclusion High maternal selenium level is significantly associated with the occurrence of fetal CHD.

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Correlation between Congenital Heart Defects and maternal copper and zinc concentrations

Cited by 23 publications

References 34 publications

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring

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