Hair analysis in health assessment

Wołowiec, Paulina; Michalak, Izabela; Chojnacka, Katarzyna; Mikulewicz, Marcin

doi:10.1016/j.cca.2013.02.001

Cited by 86 publications

(52 citation statements)

References 206 publications

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“…10,11 Blood, as an invasive biomarker, is more difficult to collect; moreover, blood and saliva have a window of detection, of approximately 36-72 h. Hair is a well-known biomarker, easy to collect and store in keeping with the established laboratory procedures, which can provide information about chronic exposure. [12][13][14][15] Oral mucosa cells are a non-invasive biomarker that is easy to collect. The advantage of this biomarker is that fixed orthodontic appliances are in direct contact with the cells, which can supply information about ion concentration.…”

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Trace metal ions release from fixed orthodontic appliances and DNA damage in oral mucosa cells by in vivo studies: A literature review

Downarowicz¹,

Mikulewicz²

2017

Adv Clin Exp Med

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An overview of professional literature referring to the release of metal ions from fixed orthodontic appliances and their influence on oral mucosa in conditions of in vivo are presented, along with a detailed analysis of the exposure of the cells of cheek mucosa epithelium to metal ions. Electronic databases (PubMed, Elsevier, Ebsco) were searched with no language restrictions. The relevant orthodontic journals and reference lists were checked for all eligible studies. A total of 38 scientific articles were retrieved in the initial search. However, only 7 articles met the inclusion criteria. Statistically significant differences in the levels of the amount of nickel ions, cobalt ions and chromium ions were observed in cells of cheek mucosa. The most biocompatible material used in the production of fixed orthodontic appliances is titanium, and the least biocompatible material is steel, which releases the largest amount of nickel and chromium. Metal ions are released from fixed orthodontic appliances only in the first phase of treatment. It is recommended to conduct further, long-term research on a larger number of patients to define the influence of using fixed orthodontic appliances and biological effect they might have on tissues.

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Trace metal ions release from fixed orthodontic appliances and DNA damage in oral mucosa cells by in vivo studies: A literature review

Downarowicz¹,

Mikulewicz²

2017

Adv Clin Exp Med

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“…The use of human hair as an bioindicator in assessing changes and abnormalities in human bodies has gained great attention in the last several decades for occupational exposure evaluation, criminal investigation, or investigation formation [2,[6][7][8][9]. Those elements, when they are deposited in hair follicle, will be sequestered in protein matrices through binding with sulfur atoms in cysteine or sulfhydryl groups in other amino acids and experienced hardening processes, keratinocytes, while the hair growth then accumulated in the hair [7][8][9][10].…”

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Assessment of Heavy Metals on Occupationally Exposed Workers from Hair Analysis

et al. 2017

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The use of human hair as a tool in assessing changes and abnormalities in human bodies has been increasing for last decades since it may reflect the health status or environmental condition of habitation or working place of individuals as well as population groups. Compared to other body tissue or fluids, hair provides an ease of elemental analysis especially in reflecting the long-term exposure. This research was conducted to determine the elemental content especially heavy metals, since they are bioaccumulated in human body organs and impact human health, in hair of workshop workers and traffic services officers as exposed groups and its comparison with control group and references data for assessing of occupational exposure. Thirty-five automotive workshop workers and 32 traffic services officers' hair specimens were collected in Bandung, while hair specimens of the control group were collected from 43 healthy individuals. The elemental concentrations in hair specimen were analyzed using neutron activation analysis (NAA) for mercury and chromium, and atomic absorption spectrometry (AAS) for lead and arsenic. The accuracy of the method was evaluated using GBW 07601 human hair certified reference material (CRM) and it was found to give good results in accordance with the certificate values. It was found that chromium, lead, and arsenic hair concentration in exposed groups (0.88, 10.7, and 0.051 mg/kg, respectively) were higher than in control group (0.27, 4.52, and 0.045 mg/kg, respectively), while mercury hair concentration of traffic services officers were higher than control group but mercury hair concentration of automotive workshop workers were lower than in control group (1.41 mg/kg). The t-test statistical results shown that mercury concentrations in one exposed group did not differ significantly from the control, but other exposed groups showed otherwise. The level of mercury in hair is strongly attributed not only to environmental exposure, but also to lifestyle and dietary habits, while t-test statistical results of chromium and lead differ significantly with p value < 0.05. These results indicate that heavy metal hair concentrations were well quantified to show the abnormalities of elemental concentration in human hair for evaluating the occupational exposure.

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“…Different research groups have used different hair washing procedures commonly using either a waterbased detergent (i.e. mixed with Triton X-100) or acetone for washing, but only a few methods have been thoroughly tested (Eastman et al, 2013;Wołowiec et al 2013) and an accepted standard method has not been identified (Kempson and Henry, 2010;Wołowiec et al, 2013).…”

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Hair Manganese as an Exposure Biomarker among Welders

Reiss

Simpson

Baker

et al. 2015

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Quantifying exposure and dose to manganese (Mn) containing airborne particles in welding fume presents many challenges. Common biological markers such as Mn in blood or Mn in urine have not proven to be practical biomarkers even in studies where positive associations were observed. However, hair Mn (MnH) as a biomarker has the advantage over blood and urine that it is less influenced by short-term variability of Mn exposure levels because of its slow growth rate. The objective of this study was to determine whether hair can be used as a biomarker for welders exposed to manganese. Hair samples (1 cm) were collected from 47 welding school students and individual air Mn (MnA) exposures were measured for each subject. MnA levels for all days were estimated with a linear mixed model using welding type as a predictor. A 30-day time-weighted average MnA (MnA 30d ) exposure level was calculated for each hair sample. The association between MnH and MnA 30d levels was then assessed. A linear relationship was observed between log-transformed MnA 30d and log-transformed MnH. Doubling MnA 30d exposure levels yields a 20% (95% confidence interval: 11-29%) increase in MnH. The association was similar for hair washed following two different wash procedures designed to remove external contamination. Hair shows promise as a biomarker for inhaled Mn exposure given the presence of a significant linear association between MnH and MnA 30d levels.

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Hair analysis in health assessment

Cited by 86 publications

References 206 publications

Trace metal ions release from fixed orthodontic appliances and DNA damage in oral mucosa cells by in vivo studies: A literature review

Trace metal ions release from fixed orthodontic appliances and DNA damage in oral mucosa cells by in vivo studies: A literature review

Assessment of Heavy Metals on Occupationally Exposed Workers from Hair Analysis

Hair Manganese as an Exposure Biomarker among Welders

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