Biopolymeric continuous core-sheath fibres, with an inner core of chitosan and alginate as the sheath, were fabricated for the first time without using a template. Hereby, the necessary conditions to achieve chitosanalginate core-sheath fibre via a wet-spinning process are presented. SEM micrographs show the cylindershaped monofilament structure of the chitosan core surrounded by the alginate sheath. The coaxial fibres exhibit a 260% increase in ultimate stress and more than 300% enhancement in the Young's modulus compared to the alginate counterpart. Release profiles from the coaxial fibre were determined using a model component. The obtained results suggest that the fibres are likely to find applications as 3D tissue scaffolds capable of drug delivery.
Development and Characterization of Novel Hybrid Hydrogel FibresAzadeh Mirabedini, Javad Foroughi*, Tony Romeo, Gordon G. Wallace*
AbstractBiopolymeric continuous core-sheath fibres, with an inner core of chitosan and alginate as the