Development and Characterization of Novel Hybrid Hydrogel Fibers

Abstract

Biopolymeric continuous core-sheath fibres, with an inner core of chitosan and alginate as the sheath, were fabricated for the first time without using a template. Hereby, the necessary conditions to achieve chitosanalginate core-sheath fibre via a wet-spinning process are presented. SEM micrographs show the cylindershaped monofilament structure of the chitosan core surrounded by the alginate sheath. The coaxial fibres exhibit a 260% increase in ultimate stress and more than 300% enhancement in the Young's modulus compared to the alginate counterpart. Release profiles from the coaxial fibre were determined using a model component. The obtained results suggest that the fibres are likely to find applications as 3D tissue scaffolds capable of drug delivery. Development and Characterization of Novel Hybrid Hydrogel FibresAzadeh Mirabedini, Javad Foroughi*, Tony Romeo, Gordon G. Wallace* AbstractBiopolymeric continuous core-sheath fibres, with an inner core of chitosan and alginate as the

Flexible Asymmetric Encapsulation for Dehydration‐Responsive Hybrid Microfibers

“…The uniaxial tensile testing was performed by moving the bottom stage down at a fixed velocity (0.2 mm s –1 ) until the fibers split. The tensile testing of individual fibers has also been reported previously for synthetic, as well as simple and composite hydrogel fibers …”

Recent Trends in Alginate, Chitosan and Alginate-Chitosan Antimicrobial Systems

“…Using alginate-chitosan mixtures can be obtained fi bers with advanced useful properties, compared to individual polymers. Wet spinning technique [69][70][71][72][73][74][75] is the most common method for manufacturing these fi bers. Using this method, it can be obtained fi bers consisting entirely of alginate-chitosan mixture [70,75], alginate coated with chitosan [69,[71][72][73] (Figure 5) or vice versa -chitosan coated with alginate [74] (Figure 6).…”

“…Wet spinning technique [69][70][71][72][73][74][75] is the most common method for manufacturing these fi bers. Using this method, it can be obtained fi bers consisting entirely of alginate-chitosan mixture [70,75], alginate coated with chitosan [69,[71][72][73] (Figure 5) or vice versa -chitosan coated with alginate [74] (Figure 6). Due to chitosan and antimicrobial compounds (sulfathiazole [71]), alginate-chitosan fi bers show antimicrobial activity -inhibit the growth of various bacteria that inhabit the skin of mammals, such as Staphylococcus aureus [69,70,72], Escherichia coli [70,71], Micrococcus luteus, Staphylococcus epidermidis [69].…”

“…Due to chitosan and antimicrobial compounds (sulfathiazole [71]), alginate-chitosan fi bers show antimicrobial activity -inhibit the growth of various bacteria that inhabit the skin of mammals, such as Staphylococcus aureus [69,70,72], Escherichia coli [70,71], Micrococcus luteus, Staphylococcus epidermidis [69]. This property together with the ability to carry cationic [74] and anionic [75] drugs, allow antimicrobial alginate-chitosan fi bers to be a potential candidate for wound dressing materials.…”

Effect of graphene oxide on the molecules of a sodium alginate–krill protein composite system and characterization of the system's composite fiber morphology and mechanical properties

“…Sodium alginate (SA) is a polysaccharide material extracted from the cell walls of brown algae by β‐ d ‐mannuronic acid and n ‐ l ‐guluronic acid via glycosidic linkages. It has excellent biocompatibility and film‐forming properties and has been widely used in the fields of medical and health materials, such as in medical dressings, tissue engineering repair materials, drug‐release materials and fiber materials . However, SA has a low strength, poor toughness, and poor water resistance, so the modification of SA has become a hotspot in recent years.…”