Haemopoietic Stem Cell Transplantation for Autoimmune Diseases

High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis

“…[1][2][3][4][5]13,14 Experiments on animal models and the effect of myeloablative-immunoablative treatment in patients with concomitant haematological and autoimmune disease (AID) constitute the background for such a new approach. [15][16][17][18][19][20][21][22][23][24] Based on animal models and experience in humans, allogeneic haematopoietic cell transplantation would represent the best option to cure poor risk AID.…”

Resolution of atopic dermatitis following allogeneic bone marrow transplantation for chronic myelogenous leukemia

“…2 Recently, some patients with coincidental autoimmune disease who underwent allogeneic bone marrow transplantation (BMT) for a malignancy have been cured of their autoimmune disease. [3][4][5][6] We describe a patient with chronic myelogenous leukemia (CML) whose atopic dermatitis resolved completely over a 4-year follow-up period, after allogeneic BMT.…”

Resolution of chronic idiopathic thrombocytopenia purpura following syngeneic peripheral blood progenitor transplant

“…[1][2][3][4] Successful allogeneic BMT has been reported in cases of autoimmune diseases including immune hemolytic anemia, rheumatoid arthritis, psoriasis, SLE, ulcerative colitis and autoimmune hepatitis. 7 There has been a case report of successful resolution of immune thrombocytopenia and anemia in a patient with Evans syndrome who received an allogeneic cord blood transplant. 8 Unfortunately, that patient died of hepatic failure nine months post transplant.…”

“…6 To date, limited information exists on the use of hematopoietic progenitor cell transplantation as a treatment for this disease. [7][8][9][10] Correspondence presentation to our center. During the 3 years preceding this referral platelet counts were frequently less than 10 000.…”