Haemophilus parainfluenzae endocarditis with multiple cerebral emboli in a pregnant woman with coronavirus

Castro, Alicia De; Abu-Hishmeh, Mohammad; Husseini, Ibrahim El; Paul, Lisa

doi:10.1016/j.idcr.2019.e00593

Cited by 11 publications

(11 citation statements)

References 15 publications

(24 reference statements)

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“…A pregnant patient was diagnosed with coronaviral infection based on positive respiratory polymerase chain reaction (PCR) and was initially managed supportively with no antibiotics. 140 However, she deteriorated and cultures on the fifth day grew Haemophilus parainfluenzae , and mitral valve vegetations were found on transesophageal echocardiography. A third case with CAD and diabetes was initially diagnosed as severe pneumonia due to MERS and heart failure, but cultures grew Candida and he died due to lack of treatment.…”

Section: Resultsmentioning

confidence: 99%

“…The literature search found nine case reports and case series on 14 patients that reported difficulty in diagnosing and management of patients with coronavirus infection and significant cardiovascular co-morbidities 68 , 135 – 142 (Supplementary Material Table 5). The quality of studies was poor due to studies having a high risk of selection bias, low representativeness, and lack of control population.…”

Section: Resultsmentioning

confidence: 99%

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Effect of coronavirus infection on the human heart: A scoping review

Tambyah

et al. 2020

Eur J Prev Cardiolog

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Background The global coronavirus disease 2019 pandemic has highlighted the importance of understanding the cardiovascular implications of coronavirus infections, with more severe disease in those with cardiovascular co-morbidities, and resulting cardiac manifestations such as myocardial injury, arrhythmias, and heart failure. Design A systematic review of the current knowledge on the effects of coronavirus infection on the cardiovascular system in humans was performed and results were summarized. Methods Databases such as MEDLINE, EMBASE, CENTRAL, Scopus, Web of Science, ClinicalTrials.gov, Chinese Knowledge Resource Integrated Database and Chinese Clinical Trial Registry were searched on 20 March 2020. Results In total, 135 studies were included, involving severe acute respiratory syndrome, Middle East respiratory syndrome, coronavirus disease 2019 and other coronaviruses. Most were case reports, case series and cohort studies of poor to fair quality. In post-mortem examinations of subjects who died from infection, around half had virus identified in heart tissues in severe acute respiratory syndrome, but none in Middle East respiratory syndrome and coronavirus disease 2019. Cardiac manifestations reported include tachycardia, bradycardia, arrhythmias, and myocardial injury, secondary to both systemic infection and treatment. Cardiac injury and arrhythmias are more prevalent in coronavirus disease 2019, and elevated cardiac markers are associated with intensive care unit admission and death. In severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019, comorbidities such as hypertension, diabetes mellitus, and heart disease are associated with intensive care unit admission, mechanical ventilation, and mortality. There were cases of misdiagnosis due to overlapping presentations of cardiovascular diseases and coronavirus infections, leading to hospital spread and delayed management of life-threatening conditions. Conclusion This review highlighted the ways in which coronaviruses affect cardiovascular function and interacts with pre-existing cardiovascular diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effect of coronavirus infection on the human heart: A scoping review

Tambyah

et al. 2020

Eur J Prev Cardiolog

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“…Twenty-one cases from 20 publications that satisfied inclusion criteria were identified 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ( Figure 1 ). There were 8 cases in the United States, 7 in Europe (Italy 3, Spain 2, United Kingdom 1 and Greece 1), 3 in the Middle East (Iran, Morocco, Tunisia), 2 in South America (Brazil and Ecuador), and 1 in Asia (Indonesia).…”

Section: Resultsmentioning

confidence: 99%

A clinical profile of infective endocarditis in patients with recent COVID-19: A systematic review

Quintero-Martinez

Hindy

Mahmood

et al. 2022

The American Journal of the Medical Sciences

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Section: Discussionmentioning

confidence: 99%

“…Whether COVID-19 facilitates translocation of H. parainfluenzae from the nasopharynx into the circulation is unknown, although H. parainfluenzae IE has been associated with other coronaviruses. 6 Whether the mitral valve vegetation was formed at presentation is unclear. The initial bedside echo was a brief assessment in the ED to rule out acute right heart decompensation and tamponade.…”

Section: Discussionmentioning

confidence: 99%

Haemophilus parainfluenzaeendocarditis presenting with symptoms of COVID-19

Finch¹,

Gerdzhikov²,

Buttery

2021

BMJ Case Rep

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A young man presented early in the UK’s second COVID-19 pandemic surge with a twelve-day history of fever, dry cough, breathlessness, myalgia and loss of smell and taste. His chest X-ray showed bilateral ground-glass opacities. He was treated for COVID-19 pneumonitis but covered for bacterial infection with antibiotics. He developed shock and respiratory failure, requiring vasopressors and continuous positive airway pressure. He improved but experienced transient visual disturbances and headache. Nasopharyngeal swabs and antibody tests for COVID-19 were negative. Blood cultures grew Haemophilus parainfluenzae. A new murmur prompted an echocardiogram. This confirmed a large, mobile mitral valve vegetation. An MRI of the brain showed bilateral embolic infarcts. He underwent urgent mitral valve repair and made an excellent recovery. Whether COVID-19 caused his presenting symptoms or facilitated the bacteraemia remains unclear. It seems more likely that infective endocarditis masqueraded as COVID-19. Clinicians should be aware of how context of the pandemic can bias diagnostic reasoning.

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Haemophilus parainfluenzae endocarditis with multiple cerebral emboli in a pregnant woman with coronavirus

Cited by 11 publications

References 15 publications

Effect of coronavirus infection on the human heart: A scoping review

Effect of coronavirus infection on the human heart: A scoping review

A clinical profile of infective endocarditis in patients with recent COVID-19: A systematic review

Haemophilus parainfluenzaeendocarditis presenting with symptoms of COVID-19

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