Haemolytic anaemia after ingestion of Neem (<i>Azadirachta indica</i>) tea

Page, Cristy; Hawes, Emily M.

doi:10.1136/bcr-2013-200890

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Hemolytic anemia with jaundice and dizziness has been reported after high dosages of herbal intake (Tea) in patient with type-2 diabetes. Although in this particular case a total discontinuation of other medications where also found, the most likely culprit was the excessive intake of the extract [28]. Early animal based studies using IM injections of sodium nimbidate at 250mg have been used for congestive heart failure, yet intravenous Neem extracts have proven to produce cardiac arrythmias cautioning their use [68,69].…”

Section: A Cautionary Talementioning

confidence: 82%

“…Clearly, the need for providing adequate compounds to stabilize or neutralize these radicals is paramount as a step in preventing or blocking an exacerbation of diseases; as these molecules will add in a positive way to the body's natural antioxidant defenses: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), nitric oxide dioxygenase (NOD) [15,25]. A simple way to provide such compounds is to supplement them in the diet, and as such, natural extracts like those derived from Neem seem to be a cost-effective way to introduce them [11,23,[26][27][28]. injury (IIRI).…”

Section: Antioxidant Effectmentioning

confidence: 99%

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Current Evidence about Neem Extracts, the Molecules and Physiological Mechanisms Their Nutritional Components Interact with

Islas¹,

Acosta²,

Escalante-Acosta³

et al. 2019

Preprint

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Plant-based alternative medicine is normally grounded on empiric cultural perception, as the main objective, these practices intent to either maintain good health or to provide a route to turn-the-tide on a specific disease or ailment. Amongst the thousands of plants that have been used and studied, Neem (Azadirachta indica) seems to have a very interesting tale to tell, since its properties to ward-off certain diseases have overtime, and in a rigorous way, been proven. The preceding concise review is a collection of some of the most relevant studies today, not only focusing on the health benefits obtained by its use, but digging into the molecular mechanisms of how the properties come about. In particular, we take a look over antioxidant properties and how these mediate and mitigate important molecules such as IL-6 and TNF-, leading the way in reducing systematic damage by oxidative stress. Further, we relate this oxidative reduction to other systemic diseases such as cancer and diabetes, as these are currently becoming the most rampant killers. As of yet not all is known about the different ways of extracting or the total composition of an extract, as these may be from different parts of the plant. Therefore, we also allude to an important cautionary view where toxicological effects and conflicting outcomes arise. Overall, presented results show a great potential for the different extracts of Neem as their antioxidant activity can be taken advantage off, and potentially used in modern medicine.

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Section: A Cautionary Talementioning

confidence: 82%

Section: Antioxidant Effectmentioning

confidence: 99%

Current Evidence about Neem Extracts, the Molecules and Physiological Mechanisms Their Nutritional Components Interact with

Islas¹,

Acosta²,

Escalante-Acosta³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…[ 47 ] Neem was also reported as a possible cause of hemolytic anemia in a 35-year-old man with glucose-6-phosphate dehydrogenase deficiency. [ 48 ] Neem leaf poisoning has been implicated in ventricular fibrillation and cardiac arrest. It may cause hypoglycemia, and has to be used with caution in patients on anti-hyperglycemic agents.…”

Section: Tradition To Sciencementioning

confidence: 99%