Haemodynamic parameters and cognitive function during modeled acute volume loss

Tuboly, Gergely; Rudas, László; Csillik, Andrea; Nagy, Andrea; Benedek, Krisztina; Benedek, György; Braunitzer, G

doi:10.1556/aphysiol.99.2012.2.4

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…In contrast to the patients reported in that study, the patients in our hyperOH group had large orthostatic drops in blood pressure with only a modest increase in HR (Table 1). This hemodynamic pattern is typical of neurogenic OH, and not consistent with a transient cause of OH such as hypovolemia [21;22]. More recently “hyperadrenergic” has been used to describe patients with upright plasma NE >3.55 nmol/L (600 pg/mL), a threshold met by only 2 of the 8 patients in Streeten’s study [8].…”

Section: Discussionmentioning

confidence: 99%

Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline)

et al. 2015

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Patients with neurogenic orthostatic hypotension (OH) typically have impaired sympathetic nervous system tone and therefore low levels of upright plasma norepinephrine. We report a subset of patients who clinically have typical neurogenic OH but who paradoxically have elevated upright levels of plasma norepinephrine. We retrospectively studied 83 OH patients evaluated at the Vanderbilt Autonomic Dysfunction Center between August 2007 and May 2013. Based upon standing norepinephrine, patients were dichotomized into a hyperadrenergic orthostatic hypotension group (hyperOH: upright NE ≥3.55 nmol/L [600 pg/mL], n=19) or a non-hyperadrenergic orthostatic hypotension group (nOH: upright NE < 3.55 nmol/L [600 pg/mL], n=64). Medical history and data from autonomic testing, including the Valsalva maneuver (VM), were analyzed. HyperOH patients had profound orthostatic falls in blood pressure, but less severe than in nOH (change in SBP: −53±31 mmHg vs. −68±33 mmHg, P=0.050; change in DBP: −18±23 mmHg vs. −30±17 mmHg, P=0.01). The expected compensatory increase in standing heart rate was similarly blunted in both hyperOH and nOH groups (84±15 bpm vs. 82±14 bpm; P=0.6). HyperOH patients had less severe sympathetic failure as evidenced by smaller falls in DBP during phase 2 of VM, and a shorter VM phase 4 blood pressure recovery time (16.5±8.9 sec vs. 31.6±16.6 sec; P<0.001) than nOH patients. Neurogenic hyperOH patients have severe neurogenic orthostatic hypotension, but have less severe adrenergic dysfunction than nOH patients. Further work is required to understand if hyperOH patients will progress to nOH or if this represents a different disorder.

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Section: Discussionmentioning

confidence: 99%

Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline)

et al. 2015

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“…High altitude studies showed that decreased perfusion has a detrimental effect on cognitive functions (Crowley et al, 1992). However, Tuboly et al (2012) found that cognitive performance (as reflected by P300 changes) was a poor marker of volume loss. In our study, blood donation did not explain the differences between the two groups as they were assessed in the same conditions, but it may limit the generalization of the results.…”

Section: Discussionmentioning

confidence: 99%

Assessing Metacognition during a Cognitive Task: Impact of “On-line” Metacognitive Questions on Neuropsychological Performances in a Non-clinical Sample

Quilès

Verdoux

Prouteau

2014

J Int Neuropsychol Soc

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Whereas metacognition is of great interest for neuropsychological practice, little is known about the impact of metacognitive questions during a neuropsychological assessment. This study explored the impact of measuring "on-line" metacognitive processes on neuropsychological performances in a non-clinical population. Participants were randomly assigned to a "standard" or a "metacognitive" neuropsychological test procedure. The "standard" procedure assessed executive functions (Modified Card Sorting Test), episodic memory ("Rappel libre Rappel indicé" 16), working memory (digit span test Wechsler Adult Intelligence Scale III) and social cognition (Faces Test). In the "metacognitive" procedure, two questions were added after each item of these tests to evaluate "on-line" metacognitive monitoring and control. Working memory performances were better and episodic memory performances lower in the "metacognitive" versus the "standard" procedure. No significant difference was found concerning executive functioning or social cognition. The assessment of "on-line" metacognition might improve working memory performances by enhancing concentration, and might impair episodic memory performances by acting as a distractor. These findings may have implications for the development of cognitive remediation programs.

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Effect of hypovolemia on efficacy of reflex maintenance of blood pressure on orthostatic challenge

Yadav

Akanksha

Jaryal

et al. 2016

High Blood Press Cardiovasc Prev

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Haemodynamic parameters and cognitive function during modeled acute volume loss

Abstract: Our study indicates that traditional sphygmomanometer based values can safely be replaced by values yielded by finger plethysmography, combined with brief orthostatic challenges and that P300 as a cognitive marker cannot be used to assess volume loss.

Cited by 4 publications

References 41 publications

Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline)

Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline)

Assessing Metacognition during a Cognitive Task: Impact of “On-line” Metacognitive Questions on Neuropsychological Performances in a Non-clinical Sample

Effect of hypovolemia on efficacy of reflex maintenance of blood pressure on orthostatic challenge

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