Haemodynamic effects of high‐dose vecuronium compared with pancuronium in beta‐blocked patients with coronary artery disease during fentanyl‐diazepam‐nitrous oxide anaesthesia

Abstract

High-dose administration of vecuronium has minimal haemodynamic effects and may thus offer a better alternative than pancuronium for long-lasting neuromuscular blockade in patients with coronary artery disease during fentanyl-diazepam-nitrous oxide anaesthesia.

Haemodynamic differences between pancuronium and vecuronium in an experimental pig model

“…The borderline increase in CI in the pancuronium group is also likely in the context of the borderline increased HR in the same group, as well as previous documentation of increased cardiac output (Marshall ; Husby et al. ). This could indicate increased autonomic nervous system activity in favour of the sympathetic nervous system.…”

The Effect of Neuromuscular Blockade on Canine Laparoscopic Ovariectomy: A Double‐Blinded, Prospective Clinical Trial

“…The reduction in DAP and MAP pressures during NMB was small and all recorded blood pressure values were within normal physiologic limits for all dogs during anesthesia . Although vecuronium has been reported to deliver cardiovascular stable NMB compared to other NMB drugs, some experiments have found vecuronium to cause cardiovascular changes . It is therefore possible that the observed change in blood pressure during NMB in this study can be directly attributed to vecuronium.…”