Investigation of the Cardiac Effects of Pancuronium, Rocuronium, Vecuronium, and Mivacurium on the Isolated Rat Atrium

Gürsoy, Sinan; Bağcıvan, İhsan; Durmuş, Nedim; Kaygusuz, Kenan; Kol, İclal Özdemir; Düğer, Cevdet; Yıldırım, Seda; Mimaroğlu, Caner

doi:10.1016/j.curtheres.2011.09.001

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…These findings suggested that cardiac effects of these agents were induced at high concentrations. Similarly, in a study by Gursoy et al., 7 cardiac effects of non-depolarizing NMBDs were examined in isolated rat atrium and the results were consistent with the relevant literature. 8 This previous study suggested that such effects could be particularly important in hypertensive patients on β-blockers in clinical practice.…”

Section: Discussionsupporting

confidence: 77%

“…These effects may be attributed to direct stimulation of β-adrenoceptors or pathological conditions, such as hypertension, where β-blocking agents, are generally used. 5 , 7 , 8 Cardiovascular effects of NMBDs on the isolated atrium have been studied on rats. 8 Because endothelial cells play a significant role in regulating hemostasis, 9 cardiovascular effects could be mediated by the endothelium.…”

Section: Introductionmentioning

confidence: 99%

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Effects of neuromuscular blocking drugs on viability of human umbilical vein endothelial cells (HUVECs)

et al. 2020

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Objective This study aimed to investigate the effects of neuromuscular blocking drugs on the viability of human umbilical vein endothelial cells (HUVECs) and to investigate whether they cause vascular complications due to cell proliferation. Methods HUVECs were cultivated with 5% CO2 at 37°C in a predefined supplemented medium over 7 days until confluence of cell monolayers. Assays were conducted during the exponential growth phase. Suxamethonium chloride, vecuronium bromide, atracurium besylate, and rocuronium bromide were used at concentrations of 10–5, 10–6, and 10–7 M in proliferation assays in which cells were incubated with these drugs for 24, 48, and 72 hours. All experiments were performed in four replicates. Results The neuromuscular blocking drugs used had comparable effects on the survivability of HUVECs. Overall, no significant difference was observed in the survivability of HUVECs in a dose-dependent manner after exposure to the study drugs. However, some significant differences in the viability of HUVECs were found among the different measurement times. Conclusions The findings of the current study support the safety of the studied neuromuscular blocking drugs in clinically relevant concentrations regarding their effects on endothelial cell proliferation.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Effects of neuromuscular blocking drugs on viability of human umbilical vein endothelial cells (HUVECs)

et al. 2020

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“…Two factors are probably responsible for this finding. First, we paralyzed the rats with pancuronium, an agent which increased baseline heart rate by its vagolytic action (Marshall 1973;Gursoy et al 2011). Our use of pancuronium might have limited stimulation-induced increases in cardiac output, which in turn might have contributed to an increase in arterial pressure.…”

Section: Discussionmentioning

confidence: 99%

Low‐frequency stimulation of group III and IV hind limb afferents evokes reflex pressor responses in decerebrate rats

Harms

Copp

Kaufman

2016

Physiological Reports

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Contraction of freely perfused hind limb muscles in decerebrate rats evokes the exercise pressor reflex, resulting in sympathetic activation and increased blood pressure. This reflex is propagated along mechanically sensitive group III and metabolically sensitive group IV afferent nerve fibers. Recent research by our laboratory has focused on the exaggeration of the exercise pressor reflex in decerebrate rats with simulated peripheral artery disease, which was induced by ligating the femoral artery for 72 h before the start of the experiment. Recently, we showed that ligating the femoral artery increased the responses of single fiber group III and IV triceps surae muscle afferents to static contraction. The objective of this study was to determine if electrical stimulation of group III and IV afferents at frequencies approximating those occurring during static contraction was capable of reflexively increasing arterial blood pressure. We directly stimulated muscle afferents in the absence of muscle contraction for both freely perfused and ligated rats. We established 0.25 Hz as the minimal stimulation frequency to observe a sustained blood pressure response. The blood pressure response increased in a graded fashion as both stimulus frequency and motor threshold were increased. Additionally, we observed similar blood pressure responses from both freely perfused and ligated rats, suggesting that spinal and medullary processing of group III and IV afferent input plays no role in augmenting the pressor response to contraction caused by femoral artery ligation.

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“…Other neuromuscular blockers like pancuronium and atracurium were used in the past to control the muscle spasm. However, their use was not recommended as Pancuronium causes tachycardia [15] and atracurium such as bradycardia and hypotension [16] which may trigger mortality in the patient with tetanus. Based on the above evidence, Vecuronium is now recommended to be used as a neuromuscular blocker in Tetanus.…”

Section: Controlling Toxin Productionmentioning

confidence: 99%

A Review on Pharmacological Management of Generalised Tetanus

Shah¹

2018

Gen Med

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Methods Two authors extensively searched electronic databases like MEDLINE/Pub Med and Google Scholar, searched with Mesh (Medical Subject Headings) terms like " tetanus", "treatment", " benzodiazepines", " Tetanus immunoglobin" from earliest possible date of 1966 to January 2018. We select the articles published in any language with preference to randomised control trial and published in recent years. We analyse the 41 articles to write this review article. Pharmacological treatment The pharmacological treatment of tetanus is guided by the following principles; Management of the muscle spasm (a) Management of autonomic dysfunctions (b) Controlling the toxin production (c) Management of unbound toxin (d) Supportive care

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Investigation of the Cardiac Effects of Pancuronium, Rocuronium, Vecuronium, and Mivacurium on the Isolated Rat Atrium

Cited by 14 publications

References 24 publications

Effects of neuromuscular blocking drugs on viability of human umbilical vein endothelial cells (HUVECs)

Effects of neuromuscular blocking drugs on viability of human umbilical vein endothelial cells (HUVECs)

Low‐frequency stimulation of group III and IV hind limb afferents evokes reflex pressor responses in decerebrate rats

A Review on Pharmacological Management of Generalised Tetanus

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