Haemodynamic effects of BM 10.188, a new orally active inotropic agent, in healthy volunteers.

Whiting, B.; Kelman, Andrew W.; Sumner, D. J.; Hillis, W. S.; Ledermann, H

doi:10.1111/j.1365-2125.1982.tb01416.x

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Systolic time intervals (STI) have previously been used to study inotropic agents (Kelman et al, 1980;Whiting et al, 1982). They are also sensitive to changes in venous return and peripheral resistance and have been shown to be useful physiological markers of the pharmacological effect of sublingual GTN (Warrington & Burgess, 1980).…”

Section: Introductionmentioning

confidence: 99%

The effect of glyceryl trinitrate ointment on heart rate–corrected systolic time intervals in angina pectoris.

Struthers¹,

Whiting²,

Hillis³

et al. 1982

Brit J Clinical Pharma

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1 Individual systolic time intervals (STI) v heart rate regression equations were determined using small doses of intravenous atropine in seven patients with angina pectoris. 2 Regression lines of the form LEVT = A+B.HR and QS2 = C + D.HR were calculated. There was no significant correlation between PEP and HR. The values of parameters A C and D were significantly different from a group of previously studied normal volunteers. 3 STI changes were recorded for 5 h after the application of GTN or placebo ointment. The active drug caused shortening of LVET and QS2 with the peak effect occurring between 105 and 180 min. After 180 min neither LVET nor QS% were significantly shortened. There was no significant effect on PEP or heart rate.

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Section: Introductionmentioning

confidence: 99%

The effect of glyceryl trinitrate ointment on heart rate–corrected systolic time intervals in angina pectoris.

Struthers¹,

Whiting²,

Hillis³

et al. 1982

Brit J Clinical Pharma

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Agents for the treatment of heart failure

Bristol¹,

Evans²

1983

Medicinal Research Reviews

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Systolic time intervals in evaluation of the negative inotropic effect after single oral doses of mexiletine and disopyramide

Rousson¹,

Piolat²,

Galleyrand³

et al. 1986

Eur J Clin Pharmacol

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A placebo-controlled, single blind, crossover study was done to evaluate the inotropic effects of single oral doses of mexiletine and disopyramide assessed by the measurement of Systolic Time Intervals (STI). Each of 8 healthy volunteers received five treatments in random order: 200 and 400 mg mexiletine, 100 and 200 mg disopyramide, and placebo. There was a significant increase in cumulated PEP after 400 mg mexiletine and 200 mg disopyramide. There was no significant change in LVET and QS2. Peak plasma levels were in the lower range of the reputed antiarrythmic levels. Plasma concentration-effect relationships are discussed. Although the study revealed large inter- and intrasubject variability in the measured STIs, it is concluded that a negative inotropic effect was detected despite the low plasma levels of the minor negative inotropic drugs.

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Haemodynamic effects of BM 10.188, a new orally active inotropic agent, in healthy volunteers.

Cited by 6 publications

References 15 publications

The effect of glyceryl trinitrate ointment on heart rate–corrected systolic time intervals in angina pectoris.

The effect of glyceryl trinitrate ointment on heart rate–corrected systolic time intervals in angina pectoris.

Agents for the treatment of heart failure

Systolic time intervals in evaluation of the negative inotropic effect after single oral doses of mexiletine and disopyramide

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