Haemodynamic Effects of Anaemia in Patients with Acute Decompensated Heart Failure

Krzesiński, Paweł; Galas, Agata; Gielerak, Grzegorz; Uziębło‐Życzkowska, Beata

doi:10.1155/2020/9371967

Cited by 8 publications

(9 citation statements)

References 27 publications

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“…Anemia might be a risk factor for adverse events in many cardiovascular conditions, such as heart failure, 13,14 CAD after acute coronary syndrome 15 or percutaneous coronary intervention (PCI), especially when the patient requires antiplatelet medication 16 . It might also increase the risk of bleeding complication.…”

Section: Discussionmentioning

confidence: 99%

Impact of anemia on clinical outcomes of patients with atrial fibrillation: The COOL‐AF registry

Krittayaphong

Pumprueg

Thongsri

et al. 2021

Clinical Cardiology

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Background To determine whether anemia is an independent risk factor for ischemic stroke and major bleeding in patients with non‐valvular atrial fibrillation (NVAF). Hypothesis Anemia in patients with NVAF increase risk of clinical complications related to atrial fibrillation. Methods We conducted a prospective multicenter registry of patients with NVAF in Thailand. Demographic data, medical history, comorbid conditions, laboratory data, and medications were collected and recorded, and patients were followed‐up every 6 months. The outcome measurements were ischemic stroke or transient ischemic attack (TIA), major bleeding, heart failure (HF), and death. All events were adjudicated by the study team. We analyzed whether anemia is a risk factor for clinical outcomes with and without adjusting for confounders. Results There were a total of 1562 patients. The average age of subjects was 68.3 ± 11.5 years, and 57.7% were male. The mean hemoglobin level was 13.2 ± 1.8 g/dL. Anemia was demonstrated in 518 (33.16%) patients. The average follow‐up duration was 25.8 ± 10.5 months. The rate of ischemic stroke/TIA, major bleeding, HF, and death was 2.9%, 4.9%, 1.8%, 8.6%, and 9.2%, respectively. Anemia significantly increased the risk of these outcomes with a hazard ratio of 2.2, 3.2, 2.9, 1.9, and 2.8, respectively. Oral anticoagulants (OAC) was prescribed in 74.8%; warfarin accounts for 89.9% of OAC. After adjusting for potential confounders, anemia remained a significant predictor of major bleeding, heart failure, and death, but not for ischemic stroke/TIA. Conclusion Anemia was found to be an independent risk factor for major bleeding, heart failure, and death in patients with NVAF.

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Section: Discussionmentioning

confidence: 99%

Impact of anemia on clinical outcomes of patients with atrial fibrillation: The COOL‐AF registry

Krittayaphong

Pumprueg

Thongsri

et al. 2021

Clinical Cardiology

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“…Anaemia in HF might also exacerbate the decompensation of HF: chronic anaemia has been linked to the retention of salt and water, a reduction in renal blood flow and the glomerular filtration rate, and neurohormonal activation, which implement the congestion status commonly observed in HF patients [ 17 ]. Krzesiński et al [ 39 ] effectively demonstrated increased thoracic fluid content—as assessed by impedance cardiography—in patients with AHF, as well as higher NT-proBNP. Our data were in line with these findings: we observed higher HI values—as assessed by BIVA ( Figure 2 E,F)—in HF patients with anaemia, as well as increased values of BNP ( Figure 2 C,D).…”

Section: Discussionmentioning

confidence: 99%

Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role

Scicchitano¹,

Iacoviello

Massari³

et al. 2023

Biomedicines

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The aim of this study was to evaluate the relationship between anaemia and biomarkers of central/peripheral congestion in heart failure (HF) and the impact on mortality. We retrospectively evaluated 434 acute/chronic HF (AHF/CHF) patients. Anaemia was defined as haemoglobin levels <12 g/dL (women) or <13 g/dL (men). The brain natriuretic peptide (BNP) and hydration index (HI) were measured. The endpoint of the study was all-cause mortality. Anaemia occurred in 59% of patients with AHF and in 35% with CHF (p < 0.001) and showed a significant correlation with the NYHA functional class and renal function. BNP and HI were significantly higher in patients with anaemia than in those without anaemia. Independent predictors of anaemia included BNP, estimated creatinine clearance (eCrCL), and HI. The all-cause mortality rate was 21%, which was significantly higher in patients with anaemia than in those without anaemia (30% vs. 14%, p < 0.001; hazard ratio: 2.6). At multivariate Cox regression analysis, BNP, eCrCL, and HI were independent predictors for mortality (Hazard ratios: 1.0002, 0.97, and 1.05, respectively), while anaemia was not. Anaemia correlates with HF status, functional class, renal function, BNP, and HI. Anaemia was not an independent predictor for mortality, acting as a disease severity marker in congestive patients rather than as a predictor of death.

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“…After numerous modification, ICG is still used for research purposes [18,19]. It was employed in studies in patients with heart failure, hypertension [20,21], children with congenital heart disease [22], and individuals with sleep apnea [23,24], chronic obstructive pulmonary disease (COPD) [25,26], and pulmonary hypertension [27,28]. Despite significant limitations of ICG [29], the method has been approved by the US Food and Drug Administration.…”

Section: Practical Applications Of Icgmentioning

confidence: 99%

Techniki impedancyjne w praktyce lekarskiej

Siebert¹

2020

Folia Cardiologica

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Hemodynamics monitoring provides important information about the performance of the heart, including preload, afterload, contractility, and pump efficiency. The most popular techniques used to be based on invasive methods, such as the Fick's formula, thermodilution, and invasive intravascular pressure monitoring, and noninvasive ultrasound-based methods such as echocardiography, transesophageal Doppler monitoring of stroke volume, and peripheral arterial tonometry. Impedance methods combined with opportunities provided by telemedicine could bring new quality to the medical practice.

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Haemodynamic Effects of Anaemia in Patients with Acute Decompensated Heart Failure

Cited by 8 publications

References 27 publications

Impact of anemia on clinical outcomes of patients with atrial fibrillation: The COOL‐AF registry

Impact of anemia on clinical outcomes of patients with atrial fibrillation: The COOL‐AF registry

Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role

Techniki impedancyjne w praktyce lekarskiej

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