Haemodynamic Effects in Healthy Horses Treated with an ACE-Inhibitor (Ramipril)

Luciani, A; Civitella, Carla; Santori, Domenico; Sconza, Sarah; Guglielmini, Carlo

doi:10.1007/s11259-007-0051-2

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…In small animal medicine, ACE inhibitors are commonly used to treat heart failure and hypertension (BENCH Study Group 1999). In equine veterinary medicine, previous research regarding ACE has investigated properties of ACE inhibitors (Luciani et al 2007), the correlation of ACE activity with endometrial fibrosis (Ganjam and Evans 2006), a possible role in the pathophysiology of laminitis (Tillman and Moore 1989;Gardner et al 2004) and in treatment of mitral valve insufficiency (Gehlen et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of two training protocols on Angiotensin I-converting enzyme (ACE) activity in horses

Costa

Davies

Anderson

et al. 2011

Equine Veterinary Journal

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Section: Introductionmentioning

confidence: 99%

Effects of two training protocols on Angiotensin I-converting enzyme (ACE) activity in horses

Costa

Davies

Anderson

et al. 2011

Equine Veterinary Journal

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“…However, the study lacked an untreated control group; therefore, it is difficult to differentiate a true effect of quinapril from that of changes in hemodynamics between time points. Oral administration of ramipril at 0.06 mg/kg attenuated the rise in blood pressure (BP) caused by exogenous angiotensin I and oral administration of ramipril at 0.2 mg/kg to healthy horses resulted in a significant decrease in BP …”

mentioning

confidence: 99%

Pharmacodynamic Evaluation of 4 Angiotensin‐Converting Enzyme Inhibitors in Healthy Adult Horses

Afonso

Giguère

Rapoport

et al. 2013

Veterinary Internal Medicne

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Background: Angiotensin-converting enzyme (ACE) inhibitors are used in horses with cardiovascular disorders despite the paucity of available data regarding their efficacy.Hypothesis: The degree of serum ACE inhibition varies considerably between drugs. Animals: Eight healthy adult horses. Methods: Randomized prospective study. Horses were fasted overnight prior to receiving one of 4 ACE inhibitors intragastrically, administered at one of 2 dosages, using a randomized Latin square design (benazepril: 0.5 and 0.25 mg/ kg; ramipril: 0.3 and 0.1 mg/kg; quinapril: 0.25 and 0.125 mg/kg; perindopril: 0.1 and 0.05 mg/kg). Serum ACE activity was measured using a kinetic spectrophotometric method.Results: There was a significant effect of drug and dosage on maximum ACE inhibition (I max ), ACE inhibition 24 hours after administration (I 24h ), and area under the curve (AUC 0-48h ). Benazepril at 0.5 mg/kg resulted in significantly higher I max (86.9 AE 7.0%) and I 24h (60.3 AE 7.9%) compared to the other drugs. There was a significant decrease in indirect blood pressure (BP) over time after administration of each drug, but differences in BP were not significantly different between drugs. Pharmacodynamic variables measured after administration of benazepril to horses with free access to hay were not significantly different from those obtained after fasting. Administration of benazepril orally once daily for 7 days did not result in a cumulative effect on ACE inhibition.Conclusions and Clinical Importance: Of the ACE inhibitors tested, oral benazepril (0.5 mg/kg) is the most effective at inhibiting serum ACE activity in healthy horses.

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“…Similarly, an effect on blood pressure was not observed. This may also be attributed to an inadequate dosing period, as a significant reduction in arterial blood pressure was not seen until Day 4 of dosing with the ACE inhibitor ramipril in horses . It is also possible that a decrease in blood pressure will not occur unless the horse is either hypertensive or in heart failure, and the renin–angiotensin–aldosterone system is activated.…”

Section: Discussionmentioning

confidence: 99%

“…Two ACE inhibitors show promise for oral bioavailability in equids. Ramipril administered orally reduces the hypertensive response to angiotensin I and reduces arterial pressure in healthy horses after oral administration . It has also been used to treat congestive heart failure in a horse .…”

Section: Introductionmentioning

confidence: 99%

Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses

Davis

Krüger

LaFevers

et al. 2014

Equine Veterinary Journal

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Haemodynamic Effects in Healthy Horses Treated with an ACE-Inhibitor (Ramipril)

Cited by 7 publications

References 7 publications

Effects of two training protocols on Angiotensin I-converting enzyme (ACE) activity in horses

Effects of two training protocols on Angiotensin I-converting enzyme (ACE) activity in horses

Pharmacodynamic Evaluation of 4 Angiotensin‐Converting Enzyme Inhibitors in Healthy Adult Horses

Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses

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