Haemodialysis in Poisoning by Sea-snake Venom

Sitprija, Visith; Sribhibhadh, R.; Benyajati, C.

doi:10.1136/bmj.3.5768.218

Cited by 40 publications

(18 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interstitial lesions consisted of edema and cellular infil trations. The findings were in accord with those observed in the previous reports [1,2,4,8]. Although glomerulonephritis and nephrotic syndrome have been described in man [11,12], this has not been our experience [2], In these two cases the glomerular changes in general were not remarkable except for mild mesangial proliferation.…”

Section: Discussionsupporting

confidence: 79%

“…Glomerulonephritis and nephrotic synsdrome are occasionally observed [11,12]. Renal infarct has been described [13], In our previous reports acute tubular necrosis with renal failure has been shown in patients bitten by seasnakes and Russell's vipers [1,2]. Further renal histological study in two additional patients with immuno fluorescent techniques forms the basis of this presentation.…”

mentioning

confidence: 94%

“…Renal involve ment in man is usually in the form of acute renal failure secondary either to the tubular necrosis or cortical necrosis [1][2][3][4][5][6][7][8][9][10]. Glomerulonephritis and nephrotic synsdrome are occasionally observed [11,12].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Further Observations of Renal Insufficiency in Snakebite

Sitprija¹,

Benyajati²,

Boonpucknavig³

1974

Nephron

Self Cite

View full text Add to dashboard Cite

Acute renal insufficiency was observed in two patients bitten by Russell’s vipers. Both patients had bleeding symptoms presumably due to disseminated intravascular coagulation. There was mild intravascular hemolysis. The serum β-1 C globulin was decreased in both cases. Renal biopsy showed tubular necrosis and arteritis. By immunofluorescent study deposition of β-1 C globulin was noted in the arterial lesion, the glomerular mesangium, and the arteriolar wall. Immunoglobulin and fibrin deposits could not be detected.

show abstract

Section: Discussionsupporting

confidence: 79%

mentioning

confidence: 94%

See 1 more Smart Citation

Further Observations of Renal Insufficiency in Snakebite

Sitprija¹,

Benyajati²,

Boonpucknavig³

1974

Nephron

Self Cite

View full text Add to dashboard Cite

show abstract

“…The need for dialysis in victims of ophidic accidents has been described by SITPRIJA et al 41, and this treatment also improves myalgia symptoms.…”

Section: Snakebite-induced Acute Kidney Injury Approachmentioning

confidence: 85%

ACUTE KIDNEY INJURY CAUSED BY Crotalus AND Bothrops SNAKE VENOM: A REVIEW OF EPIDEMIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT

Albuquerque¹,

Jacinto

Silva

et al. 2013

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYOphidic accidents are an important public health problem due to their incidence, morbidity and mortality. An increasing number of cases have been registered in Brazil in the last few years. Several studies point to the importance of knowing the clinical complications and adequate approach in these accidents. However, knowledge about the risk factors is not enough and there are an increasing number of deaths due to these accidents in Brazil. In this context, acute kidney injury (AKI) appears as one of the main causes of death and consequences for these victims, which are mainly young males working in rural areas. Snakes of the Bothrops and Crotalus genera are the main responsible for renal involvement in ophidic accidents in South America. The present study is a literature review of AKI caused by Bothrops and Crotalus snake venom regarding diverse characteristics, emphasizing the most appropriate therapeutic approach for these cases. Recent studies have been carried out searching for complementary therapies for the treatment of ophidic accidents, including the use of lipoic acid, simvastatin and allopurinol. Some plants, such as Apocynaceae, Lamiaceae and Rubiaceae seem to have a beneficial role in the treatment of this type of envenomation. Future studies will certainly find new therapeutic measures for ophidic accidents.

show abstract

“…Muscular symptoms associated with seasnake bite are improved by hemodialysis. 39 Alkalization of urine by sodium bicarbonate, if performed early-as soon as dark urine is observed or the snake is known to be myotoxic or hemotoxic-can prevent AKI in patients with myoglobinuria or hemoglobinuria. 28 In animal studies, alkalization of the urine before envenomation by Mulga snake (Pseudechis australis) or Hardwick's seasnake (Lapemis hardwickii) prevented renal pathological changes and impairment of renal function.…”

Section: Snake Bitementioning

confidence: 99%

Animal toxins and the kidney

Sitprija

2008

Nat Rev Nephrol

View full text Add to dashboard Cite

Envenomation or poisoning by toxins from animals poses an important health hazard in the tropics. Animal toxins are complex mixtures of proteins, peptides, enzymes and chemicals. These toxins exert their effects through modulation of ion channels and receptors, and via direct enzyme action. Depolarization or hyperpolarization of ion channels--caused by most marine toxins, and some snake and insect venoms--results in neuromuscular symptoms that can be associated with hemodynamic changes. Toxin enzymes, especially proteases and phospholipase A2, initiate inflammatory processes that involve the generation of proinflammatory cytokines and vasoactive mediators, resulting in systemic and renal hemodynamic alterations. Toxin enzymes also have direct effects on erythrocytes, myocytes, blood coagulation factors, vascular endothelium and epithelial cells. As a result, disseminated intravascular coagulation, bleeding diathesis, intravascular hemolysis and rhabdomyolysis are common after exposure to animal toxins. The renal manifestations of animal toxin envenomation, which are usually acute, result mainly from these enzymatic effects. All renal structures can be affected by animal toxins, and tubular necrosis is common. Acute kidney injury is attributed to decreased renal blood flow (associated with intravascular hemolysis or rhabdomyolysis), disseminated intravascular coagulation or direct tubular toxicity. Immunologic mechanisms have a minor role in the pathophysiology of nephropathy caused by animal toxins.

show abstract

Haemodialysis in Poisoning by Sea-snake Venom

Cited by 40 publications

References 3 publications

Further Observations of Renal Insufficiency in Snakebite

Further Observations of Renal Insufficiency in Snakebite

ACUTE KIDNEY INJURY CAUSED BY Crotalus AND Bothrops SNAKE VENOM: A REVIEW OF EPIDEMIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT

Animal toxins and the kidney

Contact Info

Product

Resources

About