Haemocompatibility of Modified Nanodiamonds

Wąsowicz, Michał; Ficek, Mateusz; Wróbel, Maciej S.; Chakraborty, Ruchira; Fixler, Dror; Wierzba, Pawel; Jędrzejewska‐Szczerska, Małgorzata

doi:10.3390/ma10040352

Cited by 40 publications

(23 citation statements)

References 51 publications

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“…There was decline in hemolytic toxicity by different ND-DOX conjugate in compare to plain drug, caused due to delayed release of encapsulated drug molecules in the nanodiamond conjugate. The repression of hemotoxicity of drug can be linked among other similar studies described previously 24 .…”

Section: In-vitro Drug Release Patternsupporting

confidence: 68%

Synthesis and Characterization of Nanodiamond-Doxorubicin (Dox) Conjugate for Effective Delivery against MCF-7 Cell Lines

Garg¹,

Garg²,

Sahu³

et al. 2019

J. Drug Delivery Ther.

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In this work, we have introduced a carbon nanomaterial (nanodiamond), to bind with anticancer drug doxorubicin (DOX) with via amide bond conjugation for cancer drug delivery and therapy. Nanodiamond (ND) was initially carboxylated by the surface modification along the treatment with strong alkaline solution (H2SO4:HNO3) and then activated the carboxyl moiety of ND with the addition of EDC. Anticancer drugs were bound to the ND through a succession of chemical modifications by adipic acid dihydrazide (ADH). The ND-Drug conjugate was analyzed by Nuclear Magnetic Resonance (1H-NMR) Spectroscopy, Fourier Transform Infrared (FTIR) Spectroscopy and Mass Spectroscopy (MS), Atomic Force Microscopy (AFM), Particle size, Zeta potential, Drug release, SRB assay against MCF-7 cells, and DNA fragmentation. Spectroscopic analysis confirms the conjugation of nanodiamond with different anticancer drug. AFM photomicrograph represents the surface morphological features of ND-DOX conjugates. In- vitro investigation showed that ND-DOX conjugates have slow and sustained drug release characteristics. In-vitro cytotoxicity studies, an enormous cytotoxic potential of ND-Drug conjugates were showed against cancer cell line. Above all findings were suggested that the ND-DOX conjugates may be a potential inhibitor of MCF-7 cancer cells to act as a drug candidate. According to all these data it can be confirm that the ND-DOX conjugates could be an effective agent for drug delivery and could be promising in future for tumor targeting strategy. Keywords: Nanodiamond, Sustained Release, Drug Delivery, Cytotoxicity, Conjugates

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Section: In-vitro Drug Release Patternsupporting

confidence: 68%

Synthesis and Characterization of Nanodiamond-Doxorubicin (Dox) Conjugate for Effective Delivery against MCF-7 Cell Lines

Garg¹,

Garg²,

Sahu³

et al. 2019

J. Drug Delivery Ther.

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“…transparent over a broad spectrum region, highly chemically and abrasively resistant, nontoxic and biocompatible. Therefore diamond films are often used as protective coatings in different applications [11]. On the other hand, the adhesion of diamond to various substrates (in particular glass or metals), or damage of substrates during chemical vapor deposition (CVD) are the factors that limit its wider commercial use [12].…”

Section: Introductionmentioning

confidence: 99%

Linear antenna microwave chemical vapour deposition of diamond films on long-period fiber gratings for bio-sensing applications

Ficek¹,

Niedziałkowski²,

Śmietana³

et al. 2017

Opt. Mater. Express

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The growth processes of nanocrystalline diamond (NCD) thin films on fused silica optical fibers with UV-induced long-period gratings (LPGs) were investigated with regard to biosensing applications. The films were deposited using a linear antenna microwave plasma enhanced chemical vapor deposition system, which allows for the growth of diamond at temperatures below 350°C. The films exhibited a high refractive index n = 2.32, as estimated at λ = 550 nm. The biosensing applications of NCD-coated LPG were considered in relation to bovine serum albumin (BSA) as an external medium. In response to BSA binding and the subsequent formation of a thin bio-layer on the NCD surface, the LPG resonances slightly split and shifted towards lower wavelengths.

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“…Good compatibility of detonated NDs with RBCs was reported by Wasowicz et al, who demonstrated the absence of any hemolytic activity induced by either commercial unmodified, oxygenated (hydrophilic) or hydrogenated (hydrophobic) NDs [84]. Drastic effects of NDs on white and red blood cells, with significant modification of active oxygen generation kinetics and hemolysis, have been reported in one of the first in vitro experiments considering the interaction of NDs with human blood components [85].…”

Section: Carbon Nanodiamondsmentioning

confidence: 71%

Hemocompatibility of Carbon Nanostructures

Fedel

2020

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Carbon nanostructures (CNs), such as carbon nanotubes, fullerenes, carbon dots, nanodiamonds as well as graphene and its derivatives present a tremendous potential for various biomedical applications, ranging from sensing to drug delivery and gene therapy, biomedical imaging and tissue engineering. Since most of these applications encompass blood contact or intravenous injection, hemocompatibility is a critical aspect that must be carefully considered to take advantage of CN exceptional characteristics while allowing their safe use. This review discusses the hemocompatibility of different classes of CNs with the purpose of providing biomaterial scientists with a comprehensive vision of the interactions between CNs and blood components. The various complex mechanisms involved in blood compatibility, including coagulation, hemolysis, as well as the activation of complement, platelets, and leukocytes will be considered. Special attention will be paid to the role of CN size, structure, and surface properties in the formation of the protein corona and in the processes that drive blood response. The aim of this review is to emphasize the importance of hemocompatibility for CNs intended for biomedical applications and to provide some valuable insights for the development of new generation particles with improved performance and safety in the physiological environment.

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Haemocompatibility of Modified Nanodiamonds

Cited by 40 publications

References 51 publications

Synthesis and Characterization of Nanodiamond-Doxorubicin (Dox) Conjugate for Effective Delivery against MCF-7 Cell Lines

Synthesis and Characterization of Nanodiamond-Doxorubicin (Dox) Conjugate for Effective Delivery against MCF-7 Cell Lines

Linear antenna microwave chemical vapour deposition of diamond films on long-period fiber gratings for bio-sensing applications

Hemocompatibility of Carbon Nanostructures

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