Hemocompatibility of Carbon Nanostructures

Fedel, Mariangela

doi:10.3390/c6010012

Cited by 20 publications

(15 citation statements)

References 228 publications

(373 reference statements)

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“…In future studies, haemotoxicity and cytotoxicity tests [26,[89][90][91][92][93] would assist in improving our understanding of the effects of fullerene oxygen derivatives on biological systems with ranging complexities.…”

Section: Discussionmentioning

confidence: 99%

Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Kovel

Kicheeva

Vnukova

et al. 2021

IJMS

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Fullerene is a nanosized carbon structure with potential drug delivery applications. We studied the bioeffects of a water-soluble fullerene derivative, fullerenol, with 10-12 oxygen groups (F10-12); its structure was characterized by IR and XPS spectroscopy. A bioluminescent enzyme system was used to study toxic and antioxidant effects of F10-12 at the enzymatic level. Antioxidant characteristics of F10-12 were revealed in model solutions of organic and inorganic oxidizers. Low-concentration activation of bioluminescence was validated statistically in oxidizer solutions. Toxic and antioxidant characteristics of F10-12 were compared to those of homologous fullerenols with a higher number of oxygen groups:F24-28 and F40-42. No simple dependency was found between the toxic/antioxidant characteristics and the number of oxygen groups on the fullerene’s carbon cage. Lower toxicity and higher antioxidant activity of F24-28 were identified and presumptively attributed to its higher solubility. An active role of reactive oxygen species (ROS) in the bioeffects of F10-12 was demonstrated. Correlations between toxic/antioxidant characteristics of F10-12 and ROS content were evaluated. Toxic and antioxidant effects were related to the decrease in ROS content in the enzyme solutions. Our results reveal a complexity of ROS effects in the enzymatic assay system.

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Section: Discussionmentioning

confidence: 99%

Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Kovel

Kicheeva

Vnukova

et al. 2021

IJMS

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“…They are very promising materials in gene and drug delivery systems, cancer treatment, bio-sensing, and stem cell therapy. Additionally, for enhanced efficacy, they can easily be functionalized with chemical groups and antibacterial and anti-inflammatory compounds (Fedel 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Application of non-metal nanoparticles, as a novel approach, for improving the stability of blood products: 2011–2021

Mehrizi

Ardestani

2022

Prog Biomater

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Despite the importance of the proper quality of blood products for safe transfusion, conventional methods for preparation and their preservation, they lack significant stability. Non-metal nanoparticles with particular features may overcome these challenges. This review study for the first time provided a comprehensive vision of the interaction of non-metal nanoparticles with each blood product (red blood cells, platelets and plasma proteins). The findings of this review on the most effective nanoparticle for improving the stability of RBCs indicate that graphene quantum dots and nanodiamonds show compatibility with RBCs. For increasing the stability of platelet products, silica nanoparticles exhibited a suppressive impact on platelet aggregation. Pristine graphene also shows compatibility with platelets. For better stability of plasma products, graphene oxide was indicated to preserve free human serum albumin from thermal shocks at low ionic strength. For increased stability of Factor VIII, mesoporous silica nanoparticles with large pores exhibit the superb quality of recovered proteins. Furthermore, 3.2 nm quantum dots exhibited anticoagulant effects. As the best promising nanoparticles for immunoglobulin stability, graphene quantum dots showed compatibility with γ-globulins. Overall, this review recommends further research on the mentioned nanoparticles as the most potential candidates for enhancing the stability and storage of blood components. Graphical abstract

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“…It is also impressive that these nanoparticles can potentially be exploited in high-priority biorelated fields. This has recently motivated research on the biocompatibility of the carbon interface and investigation of how carbons may replicate the affinity and transport properties of proteins [31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Umbrella Sampling Simulations of Carbon Nanoparticles Crossing Immiscible Solvents

Gotzias

2022

Molecules

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We use molecular dynamics to compute the free energy of carbon nanoparticles crossing a hydrophobic–hydrophilic interface. The simulations are performed on a biphasic system consisting of immiscible solvents (i.e., cyclohexane and water). We solvate a carbon nanoparticle into the cyclohexane layer and use a pull force to drive the nanoparticle into water, passing over the interface. Next, we accumulate a series of umbrella sampling simulations along the path of the nanoparticle and compute the solvation free energy with respect to the two solvents. We apply the method on three carbon nanoparticles (i.e., a carbon nanocone, a nanotube, and a graphene nanosheet). In addition, we record the water-accessible surface area of the nanoparticles during the umbrella simulations. Although we detect complete wetting of the external surface of the nanoparticles, the internal surface of the nanotube becomes partially wet, whereas that of the nanocone remains dry. This is due to the nanoconfinement of the particular nanoparticles, which shields the hydrophobic interactions encountered inside the pores. We show that cyclohexane molecules remain attached on the concave surface of the nanotube or the nanocone without being disturbed by the water molecules entering the cavity.

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Hemocompatibility of Carbon Nanostructures

Cited by 20 publications

References 228 publications

Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Application of non-metal nanoparticles, as a novel approach, for improving the stability of blood products: 2011–2021

Umbrella Sampling Simulations of Carbon Nanoparticles Crossing Immiscible Solvents

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