Haemochromatosis and dementia: cause or contributor?

Hanmanthraya, Bheemraya; Byrne, Andrew

doi:10.1002/pnp.378

Cited by 1 publication

(1 citation statement)

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“…Overaccumulation of iron in the mitochondria, oxidative stress, and mitochondrial dysfunction are some of the cofactors that play a role in AD pathology. Moreover, in dementia, iron overload contributes to an accelerated decline in cognition [ 69 ]. Mitoferrin-1 is associated with iron homeostasis and its up-regulation contributes to the overaccumulation of iron in mitochondria.…”

Section: Proteins Associated With Neuro- Toxicity and Neurodegeneratimentioning

confidence: 99%

A Comprehensive Review of Alzheimer’s Association with Related Proteins: Pathological Role and Therapeutic Significance

Kumar

Sharma

2020

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: Alzheimer’s is an insidious, progressive, chronic neurodegenerative disease which causes the devastation of neurons. Alzheimer's possess complex pathologies of heterogeneous nature counting proteins as one major factor along with enzymes and mutated genes. Proteins such as amyloid precursor protein (APP), apolipoprotein E (ApoE), presenilin, mortalin, calbindin-D28K, c-reactive protein, heat shock proteins (HSPs), and prion protein are some of chief elements in the foremost hypotheses of AD like amyloid-beta (Aβ) cascade hypothesis, tau hypothesis, and cholinergic neuron damage etc. Disturbed expression of these proteins results in synaptic dysfunction, cognitive impairment, memory loss, and neuronal degradation. On the therapeutic ground, attempts of developing anti-amyloid, anti-inflammatory, anti-tau therapies are on peek having APP and tau as putative targets. Some proteins e.g. HSPs which ameliorate oxidative stress, calpains which helps in regulating synaptic plasticity, and calmodulin-like skin protein (CLSP) with its neuroprotective role are few promising future targets for developing anti-AD therapies. On diagnostic grounds of AD C-reactive protein, pentraxins, collapsin response mediator protein-2, and growth-associated protein-43 represents the future of new possible biomarkers for diagnosing AD. The last few decades were concentrated over identifying and studying protein targets of AD. Here, we reviewed the physiological/pathological roles and therapeutic significance of nearly all the proteins associated with AD that addresses putative as well as probable targets for developing effective anti-AD therapies.

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Section: Proteins Associated With Neuro- Toxicity and Neurodegeneratimentioning

confidence: 99%