Haematological complications of HIV Infection

Opie, Jessica

doi:10.7196/samj.5595

Cited by 60 publications

(94 citation statements)

References 5 publications

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“…Literature also supports that some mycobacteria such as M. tuberculosis and M. avium complex can cause peripheral blood cytopenia in HIV patients but no such documentation with M. ulcerans is currently available. 45 Persistent anemia resulting from a BU/HIV coinfection could account for the delayed healing of wounds (median time to wound healing being 37 weeks) of the cases presented here.…”

Section: Discussionmentioning

confidence: 99%

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Tuffour

Owusu-Mireku

Ruf

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The synergy between Mycobacterium tuberculosis infection and human immunodeficiency virus (HIV)/ acquired immunodeficiency syndrome is well established but not so in Buruli ulcer (BU). We screened confirmed BU cases for HIV infection and followed seven BU/HIV-coinfected patients. Management of BU/HIV was based on the World Health Organization guidelines and patient condition. The HIV positivity among BU patients (8.2%; 11/134) was higher compared with that of general patients attending the facility (4.8%; 718/14,863; P = 0.07) and that of pregnant women alone (2.5%; 279/11,125; P = 0.001). All seven BU/HIV-coinfected cases enrolled in the study presented with very large (category III) lesions with four having multiple lesions compared with 54.5% of category III lesions among HIV-negative BU patients. During the recommended BU treatment with streptomycin and rifampicin (SR) all patients developed immune infiltrates including CD4 T cells in their lesions. However, one patient who received antiretroviral therapy (ART) 1 week after beginning SR treatment developed four additional lesions during antibiotic treatment, while two out of the four who did not receive ART died. Further evidence is required to ascertain the most appropriate time to commence ART in relation to SR treatment to minimize paradoxical reactions.

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Section: Discussionmentioning

confidence: 99%

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Tuffour

Owusu-Mireku

Ruf

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…15 Multiple pathogenic mechanisms have been suggested, including impaired hematopoiesis and immune-mediated. 16 Cytopenia can result from HIV infection, opportunistic infections, or as a consequence of drug treatment.…”

Section: Thrombocytopenia In Hivmentioning

confidence: 99%

Hematological abnormalities in HIV infected individuals in correlation to CD4 counts and ART status

Manimaran

Hemanathan

et al. 2016

Asian J Med Sci

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Background: HIV is pandemic and remains as a public health concern for many decades. This infection though associated with many opportunistic infections and neoplasms, it is further complicated with marked hematological abnormalities. The aim of this study is to determine the magnitude & severity of hematological abnormalities in HIV infected individuals and also to analyze these abnormalities in correlation with the CD4 counts. We also compared these hematological abnormalities in patients on ART and those not on ART.Materials and Methods: The study was conducted for a period of one year, on 120 HIV positive cases including both patients on ART & not on ART. Controls with similar age and sex distribution was set up. The blood samples were collected and processed in an automated cell counter. The parameters were tabulated and analyzed with respect to CD4 count & ART status.Results: Among the total of 120 HIV cases, 77% had anemia, 21% had leucopenia and 5% had thrombocytopenia. The magnitude and severity of anemia, leucopenia, thrombocytopenia and other parameters was found to be more in patients not on ART, when compared to patients on ART. Similarly, the magnitude and severity of most of hematological abnormalities were inversely proportional to the CD4 count in non-ART cases but not with cases on ART.Conclusion: The basic hematological parameters can be used as a prospective screening test to assess the severity and progression of HIV infection when CD4 count is not available. These parameters can also be used to assess the response to anti-retroviral treatment. Therefore, these basic hematological investigations readily available at all medical centers are of great use while treating HIV infected patients.Asian Journal of Medical Sciences Vol.7(4) 2016 14-18

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“…Definitive diagnosis is established on biopsy. 3,4,8 Lymphoma in HIV is more widespread and presents with extensive organ involvement than in the HIVnegative population. 7 Traditional treatment modalities include chemotherapy alone or in combination with irradiation therapy.…”

Section: In Our Series All Patients Had Diffuse Large B-cell Nhlmentioning

confidence: 99%

“…1,2 With more than six million South Africans infected with HIV and 60 per cent of them already receiving highly active antiretroviral therapy (HAART), HIV-associated morbidity and mortality have decreased significantly. 3 However, the incidence of AIDS-related lymphoma has not decreased as much and remains a major therapeutic problem. 3 Skeletal manifestations of this entity in patients with HIV infection are rarely reported in the literature.…”

Section: Osseous Manifestations Of Non-hodgkin's Lymphoma In Human Immentioning

confidence: 99%

“…3 However, the incidence of AIDS-related lymphoma has not decreased as much and remains a major therapeutic problem. 3 Skeletal manifestations of this entity in patients with HIV infection are rarely reported in the literature. Any bone, except small bones of hands and feet, can be involved and radiological manifestations are variable making diagnosis difficult and sometimes missed.…”

Section: Osseous Manifestations Of Non-hodgkin's Lymphoma In Human Immentioning

confidence: 99%

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Osseous manifestations of non-Hodgkin's lymphoma in Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS)

Magagula

Rasool

Ramdial³

et al. 2015

SA orthop. j.

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Haematological complications of HIV Infection

Cited by 60 publications

References 5 publications

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Hematological abnormalities in HIV infected individuals in correlation to CD4 counts and ART status

Osseous manifestations of non-Hodgkin's lymphoma in Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS)

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