Haematological and immunological data of Chinese children infected with coronavirus disease 2019

Xiong, Xiaoli; Chua, Gilbert T.; Chi, Shuiqing; Kwan, Mike Yat Wah; Wong, Wilfred Hing Sang; Zhou, Aifen; Shek, Chi Chiu; Tung, Keith T. S.; Qin, Huan; Wong, Rosa S.; Li, Xue; Chen, Peng; Li, Shuai; Chui, Celine S L; Tso, Winnie W. Y.; Ho, Marco H. K.; Wong, Ian Chi Kei; Chan, Godfrey C. F.; Lau, Yu Lung; Wong, Kenneth K.; Chung, Patrick Ho Yu; Li, Hui; Tam, Paul Kwong Hang; Tang, Shao tao; lp, Patrick

doi:10.1016/j.dib.2020.105953

Cited by 19 publications

(22 citation statements)

References 2 publications

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“…However, another study showed a higher number of CD4 T cells producing IFN-γ in comparison with a control group (without disease) [ 26 ]. In children with COVID-19, IFN-γ is increased, but with inferior levels than we found, suggesting a less severe disease in the pediatric population [ 27 ]. In cardiomyocytes, there is an up-regulation of genes responsible for IFN-γ suppression, also suggesting an effect IFN-γ in the cardiac function, in a sepsis-like pattern [ 28 ].…”

Section: Discussionmentioning

confidence: 86%

IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection

et al. 2020

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Section: Discussionmentioning

confidence: 86%

IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection

et al. 2020

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“…Also, when we compared the complete blood count for symptomatic against asymptomatic patients, we didn't find any significant differences, except for the monocytes count. Xiong et al (2020) found that symptomatic COVID-19 infected children had a significantly higher monocytes count than asymptomatic patients (Xiong et al, 2020). Regarding this aspect, there aren't homogenous conclusions at this time.…”

Section: Discussionmentioning

confidence: 93%

Characteristics of the pediatric patients diagnosed with SARS-CoV-2 infection in a Romanian children’s hospital: a retrospective study

Gavriliu

Murariu

Potop

et al. 2021

PeerJ

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Background To date, information on COVID-19 pediatric patients is still sparse. We aimed to highlight the epidemiological and clinical data regarding SARS-CoV-2 infection in children and adolescents to improve the understanding of the disease in this age group and inform physicians during the ongoing COVID-19 pandemic. Methods We conducted a retrospective, observational study in “Marie Curie” Emergency Children’s Hospital from Bucharest, Romania. We analyzed clinical and epidemiological characteristics of the patients confirmed with SARS-CoV-2 infection, between April 1, 2020–October 31, 2020. Results A total of 172 patients aged 0–18 years were included, 79 (45.93%) female and 93 (54.07%) male patients. 28 (16.28%) patients had co-morbidities (more often identified in asymptomatic group; p < 0.0001). 47 (27.32%) had exposure to an identified source. 30 (17.44%) patients were asymptomatic; 142 (85.56%) had mild or moderate disease. The most frequent symptoms were: pyrexia (78.87%), digestive symptoms (50%), cough (40.14%). Chest X-ray was performed in 50 patients and it was abnormal in half of them, all being symptomatic. About 2/3 of the evaluated patients had normal leukocytes. The most common hematological change was lymphopenia; monocytes tended to be higher in symptomatic patients. About 40% of the patients were admitted; none required admission to ICU. No significant differences were found between symptomatic and asymptomatic patients regarding gender, age distribution, and exposure to a source. Conclusions All the patients had asymptomatic, mild or moderate disease. Patients with comorbidities, classically considered high risk patients, presented the same pattern of disease.

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“…On the other hand, immunological data of children with COVID-19 infection were also reported. Xiong et al found that children with symptomatic COVID-19 infection had significantly higher monocyte counts [ 68 ]. Moreover, the causes of different severity of COVID-19 infection between children and adults can be analyzed in future.…”

Section: Covid-19 and Immune Functionsmentioning

confidence: 99%

COVID-19 illness and autoimmune diseases: recent insights

Liu

Yin

et al. 2021

Inflamm. Res.

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Background The aim of this review is to explore whether patients with autoimmune diseases (AIDs) were at high risk of infection during the COVID-19 epidemic and how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic affected immune system. Methods A systematic literature search was performed using the foreign databases (NCBI, web of science, EBSCO, ELSEVIER ScienceDirect) and Chinese databases (WanFang, CNKI (China National Knowledge Infrastructure), VIP, CBM) to locate all relevant publications (up to January 10, 2021). The search strategies used Medical Search Headings (MeSH) headings and keywords for “COVID-19” or “SARS-CoV-2” or “coronavirus” and “autoimmune disease”. Results This review evaluates the effect of SARS-CoV-2 on the immune system through ACE-2 receptor binding as the main pathway for cell attachment and invasion. It is speculated that SARS-COV-2 infection can activate lymphocytes and inflammatory response, which may play a role in the clinical onset of AIDs and also patients were treated with immunomodulatory drugs during COVID-19 outbreak. Preliminary studies suggested that the risk of developing severe forms of COVID-19 in patients with AIDs treated with immunomodulators or biologics might not increase. A large number of samples are needed for further verification, leading to an excessive immune response to external stimuli. Conclusion The relationship between autoimmune diseases and SARS-CoV-2 infection is complex. During the COVID-19 epidemic, individualized interventions for AIDs should be provided such as Internet-based service.

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Haematological and immunological data of Chinese children infected with coronavirus disease 2019

Cited by 19 publications

References 2 publications

IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection

IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection

Characteristics of the pediatric patients diagnosed with SARS-CoV-2 infection in a Romanian children’s hospital: a retrospective study

COVID-19 illness and autoimmune diseases: recent insights

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