Haemato-Biochemical, Radiographic and Clinical Outcome in Healing of Femoral Fracture With Retrograde Intramedullary Pin in Conjunction With Demineralized Bone Matrix in Dogs

Singh, Chandeep; Sarma, K. K.; Kalita, Dhruba Jyoti; Tamuly, S; Hussain, Jakir; Deuri, Biswajit; Nath, P. J.

doi:10.18006/2017.5(2).201.207

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The findings on the day, 14 post-surgery in all three groups demonstrated appropriate fracture alignment in animals of all groups, similarly, Singh et al (2017) also recorded the appropriate fracture alignment on day 21 using IM-Pin in dogs. Furthermore, the extent of reduction in the gap in all three groups was different.…”

Section: Discussionsupporting

confidence: 61%

Radiological Assessment of Critically Sized Femur Fracture Healing Using a Combination of Intramedullary Pin with Polymethylmethacrylate and Calcium Phosphate in Dog Model

2024

Int J Vet Sci

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This study aimed to investigate hypotheses related to critical-size bone defect reconstruction and compare the radiological parameters of Polymethylmethacrylate (PMMA) and calcium phosphate (CaP) bone materials. The research involved 36 healthy dogs divided into three groups (A, B, and C) with 12 animals in each group. Group A was treated with an intramedullary pin (IM-pin), group B was treated with PMMA in combination with an IM-pin, and group C was treated with CaP based bone graft material in combination with an IM-pin. The study assessed various endpoints at 14 th , 28 th , 45 th , and 60 th days post-surgery. The results indicate that regular radiological assessments were conducted in all three groups to evaluate fracture alignment and bone healing. On day 14 th postsurgery, all groups showed appropriate fracture alignment, with varying degrees of gap reduction. Group A (IM pin only) had minimal gap reduction, while groups B (IM pin + PMMA) and C (CaP + IM pin) showed slight gap reduction. By day 28 th , all groups demonstrated evidence of bone healing and callus formation, with groups B and C showing clearer callus formation in radiographs. In contrast, group A had considerable gap reduction due to increased immature callus formation and hyperplasia of surrounding tissues. On day 45 th , substantial bone healing and callus formation were observed in all groups. Groups B and C exhibited prominent callus formation, indicating rapid healing and gap filling, while in group A, radiographs showed growth on both sides but an unfilled gap. By day 60 th , fracture union was evident in groups B and C, while animals in group A treated with the IM pin only showed randomized luxation and an increased gap. It was concluded from the present study that radiographic results show the IM-Pin PMMA has proved to be the ideal implant material for femur bone fracture in dogs.

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Section: Discussionsupporting

confidence: 61%

Radiological Assessment of Critically Sized Femur Fracture Healing Using a Combination of Intramedullary Pin with Polymethylmethacrylate and Calcium Phosphate in Dog Model

2024

Int J Vet Sci

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Multi‐ion‐doped nano‐hydroxyapatite‐coated titanium intramedullary pins for long bone fracture repair in dogs—Clinical evaluation

et al. 2021

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Plasma spray nano-hydroxyapatite-coated titanium intramedullary implants doped either with 5% zinc, 2.5% strontium, and 2.5% fluorine ions or with 5% zinc, 5% strontium, and 2.5% silver ions were evaluated compared with plasma spray nano-hydroxyapatite-coated titanium intramedullary implant and uncoated titanium intramedullary implants for open reduction and internal immobilization in 24 clinical cases of long bone fracture repair in dogs. Fracture-healing limb outcome was evaluated clinically, that is, radiographically. Biochemical estimation of serum calcium, serum phosphorus, alkaline phosphatase (ALP), and bone markers (bone ALP [BALP] and C-telopeptide of type 1 collagen [CTX]) was carried out on 0th day, 3rd week, 6th, and 9th week postoperatively. Multi-ion-doped plasma spray nano-hydroxyapatite-coated titanium intramedullary implants were found to be superior to plasma spray nano-hydroxyapatite-coated titanium intramedullary implants and uncoated titanium intramedullary implants in terms of all the parameters studied. Using plasma spray nano-hydroxyapatite-coated titanium implants doped with multi ions, that is, 5% zinc, 5% strontium, and 2.5% silver gave the best results in fracture repair followed by the implants doped with 5% zinc, 2.5% strontium, and 2.5% fluorine ions. Earliest and excellent limb usage with no postoperative complications was the hallmark of the use of these multi-ion-doped implants with higher serum calcium, serum phosphorus, ALP, BALP, and CTX values up to 3rd postoperative week and no lameness on the 21st day. K E Y W O R D S coated titanium intramedullary pins, dogs, long bone fracture repair, multi-ion-doped, nanohydroxyapatite 1 | INTRODUCTION Fracture of long bones is a common orthopedic condition in dogs. The intramedullary pinning is a simple and economic method of immobilization of the diaphyseal fractures. 1 The materials used for orthopedic implants should possess excellent biocompatibility without cytotoxicity, superior corrosion resistance in the body environment, excellent combination of high strength and low modulus, high fatigue and wear resistance, and high ductility. Stainless steel, cobalt, chromium alloys, and titanium-based alloys are currently used for orthopedic implants, and these materials exhibit a tendency to fail after long-term use due to various reasons such as high modulus compared to that of bone, low wear, corrosive resistance, and lack of biocompatibility necessitating the development of appropriate materials with high longevity and excellent biocompatibility. 2 Titanium and its alloys are preferred for load-bearing orthopedic implants due to the superior corrosion resistance as well as fatigue

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Haemato-Biochemical, Radiographic and Clinical Outcome in Healing of Femoral Fracture With Retrograde Intramedullary Pin in Conjunction With Demineralized Bone Matrix in Dogs

Cited by 2 publications

References 15 publications

Radiological Assessment of Critically Sized Femur Fracture Healing Using a Combination of Intramedullary Pin with Polymethylmethacrylate and Calcium Phosphate in Dog Model

Radiological Assessment of Critically Sized Femur Fracture Healing Using a Combination of Intramedullary Pin with Polymethylmethacrylate and Calcium Phosphate in Dog Model

Multi‐ion‐doped nano‐hydroxyapatite‐coated titanium intramedullary pins for long bone fracture repair in dogs—Clinical evaluation

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