Haemangiosarcoma of the interventricular septum in a dog

Thompson, D J; Cave, Nick; Scrimgeour, A. B.; Thompson, KG

doi:10.1080/00480169.2011.609479

Cited by 8 publications

(12 citation statements)

References 28 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HSA most commonly develops in the right atrium and usually as solitary tumors; however, multiple nodulation can occur within the atrium, auricle, and adjacent tissues [ 1 , 5 , 15 , 87 , 178 , 179 , 180 ]. Less common locations include the right ventricle, left-sided heart chambers, and intraventricular septum [ 5 , 180 , 182 , 183 , 184 , 185 ].…”

Section: Cardiac Hemangiosarcomamentioning

confidence: 99%

“…Cardiac/pericardial neoplasms account for more than 60% of pericardial effusion cases in dogs [ 178 ]. However, it is important to emphasize that the absence of pericardial effusion does not rule out the presence of cardiac mass [ 1 , 183 ].…”

Section: Cardiac Hemangiosarcomamentioning

confidence: 99%

“…The clinical signs of affected animals include lethargy, apathy, anorexia, weakness, weight loss, emesis, exercise intolerance, dyspnea, cough, syncope, and collapse [ 15 , 28 , 178 , 179 , 180 , 183 , 188 , 189 , 190 , 191 ]. Physical examination revealed muffled cardiac and pulmonary auscultation, arrhythmias, weak pulse, jugular distention, pale mucous membranes, abdominal distension, dehydration, tachypnea, and tachycardia [ 5 , 15 , 28 , 179 , 180 , 189 , 190 ].…”

Section: Cardiac Hemangiosarcomamentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

Nardi

Massoco

Fonseca-Alves

et al. 2023

Cancers

View full text Add to dashboard Cite

Hemangiosarcoma is a mesenchymal neoplasm originating in the endothelial cells of blood vessels; they can be classified as non-visceral and visceral types. Non-visceral hemangiosarcomas can affect the skin, subcutaneous tissues, and muscle tissues; visceral hemangiosarcomas can affect the spleen, liver, heart, lungs, kidneys, oral cavity, bones, bladder, uterus, tongue, and retroperitoneum. Among domestic species, dogs are most affected by cutaneous HSA. Cutaneous HSA represents approximately 14% of all HSA diagnosed in this species and less than 5% of dermal tumors, according to North American studies. However, Brazilian epidemiological data demonstrate a higher prevalence, which may represent 27 to 80% of all canine HSAs and 13.9% of all skin neoplasms diagnosed in this species. Cutaneous HSA most commonly affects middle-aged to elderly dogs (between 8 and 15 years old), with no gender predisposition for either the actinic or non-actinic forms. The higher prevalence of cutaneous HSA in some canine breeds is related to lower protection from solar radiation, as low skin pigmentation and hair coverage lead to greater sun exposure. Actinic changes, such as solar dermatosis, are frequent in these patients, confirming the influence of solar radiation on the development of this neoplasm. There are multiple clinical manifestations of hemangiosarcoma in canines. The diagnostic approach and staging classification of cutaneous HSAs are similar between the different subtypes. The definitive diagnosis is obtained through histopathological analysis of incisional or excisional biopsies. Cytology can be used as a presurgical screening test; however, it has little diagnostic utility in cases of HSA because there is a high risk of blood contamination and sample hemodilution. Surgery is generally the treatment of choice for dogs with localized non-visceral HSA without evidence of metastatic disease. Recently, electrochemotherapy (ECT) has emerged as an alternative therapy for the local ablative treatment of different neoplastic types; the use of radiotherapy for the treatment of dogs with cutaneous HSA is uncommon. There is greater consensus in the literature regarding the indications for adjuvant chemotherapy in subcutaneous and muscular HSA; doxorubicin is the most frequently used antineoplastic agent for subcutaneous and muscular subtypes and can be administered alone or in combination with other drugs. Other therapies include antiangiogenic therapy, photodynamic therapy, the association of chemotherapy with the metronomic dose, targeted therapies, and natural products. The benefits of these therapies are presented and discussed. In general, the prognosis of splenic and cardiac HSA is unfavorable. As a challenging neoplasm, studies of new protocols and treatment modalities are necessary to control this aggressive disease.

show abstract

Section: Cardiac Hemangiosarcomamentioning

confidence: 99%

Section: Cardiac Hemangiosarcomamentioning

confidence: 99%

Section: Cardiac Hemangiosarcomamentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

Nardi

Massoco

Fonseca-Alves

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…[1][2][3][10][11][12][13][14][15][16][17][18] The most common types of cardiac neoplasia include hemangiosarcoma, chemodectoma, ectopic thyroid carcinoma, and lymphoma. 3,12,16,17 The location of the mass within the heart, size of the mass, and invasiveness determines the symptoms and the potential options for treatment. Clinical signs associated with right ventricular outflow tract obstructions are variable, but they can include exertional syncope, congestive heart failure, and anasarca.…”

Section: Introductionmentioning

confidence: 99%

Inflow Venous Occlusion for Intracardiac Resection of an Occluding Right Ventricular Tumor

Worley

Orton

Kroner

2016

Journal of the American Animal Hospital Association

View full text Add to dashboard Cite

Use of normothermic venous inflow occlusion enabled removal of an intracardiac tumor in a 4 yr old, 27 kg, spayed female Airedale terrier with a history of appendicular osteosarcoma and recent exertional syncope. Inflow venous occlusion via a median sternotomy thoracotomy without hypothermia was used to access the mineralized mass within the right ventricular outflow tract. Duration of circulatory arrest was 70 s for this beating heart surgery. A circumscribed intracardiac chondrosarcoma tumor was marginally resected in this dog, successfully alleviating exertional syncope and restoring a normal echogenic appearance of the right heart. Asymptomatic intracardiac chondrosarcoma recurrence and pulmonary metastasis was detected at 309 days and cardiopulmonary arrest occurred 372 days following intracardiac surgery. Use of inflow occlusion is a viable technique for select intracardiac tumors in dogs with preoperative planning.

show abstract

“…Cardiac hemangiosarcoma is the most frequently reported cardiac tumour in dogs 3 . Despite this, and many published studies, an interventricular septal location without right atrial involvement appears to be very uncommon 4‐8 . Furthermore, hemangiosarcoma is the most common secondary intracranial neoplasm 9 .…”

mentioning

confidence: 99%

A neurological presentation caused by brain metastases in a dog with interventricular septal hemangiosarcoma

et al. 2021

View full text Add to dashboard Cite

Background Brain metastases are well known for disseminated hemangiosarcoma involving the right atrium/auricle. Case report An 8‐year‐old male Australian Shepherd Dog presented with a 3‐day history of circling to the left. A neurological examination revealed obtunded mentation, right hemi‐inattention, bilateral strabismus towards the left side and absent physiological nystagmus. In addition, the dog had muffled heart sounds on auscultation and exercise‐induced weakness. Laboratory findings included hypercoagulability and marked elevation in the C‐reactive protein concentration. Electrocardiography detected a sinus rhythm with right bundle‐branch block and ventricular bigeminy. Echocardiography revealed an extensive interventricular septal mass. Due to the grave prognosis, the owners elected for euthanasia, and a complete necropsy was performed. The main pathological findings were an interventricular septal and left ventricular hemangiosarcoma, with metastases in the brain, lungs, spleen and adrenal glands. No evidence of tumour infiltration was found in the right atrium. Conclusion To the authors' knowledge, this is the first report of neurological signs due to confirmed brain metastases in a dog with interventricular septal hemangiosarcoma. Although the right atrium is the main location for cardiac hemangiosarcoma, the interventricular septum should be evaluated in all cases.

show abstract

Haemangiosarcoma of the interventricular septum in a dog

Cited by 8 publications

References 28 publications

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

Inflow Venous Occlusion for Intracardiac Resection of an Occluding Right Ventricular Tumor

A neurological presentation caused by brain metastases in a dog with interventricular septal hemangiosarcoma

Contact Info

Product

Resources

About