Habitually inactive physically – a proposed procedure of counteracting cognitive decline in women with diminished insulin sensitivity through a high-intensity circuit training program

Micielska, Katarzyna; Kortas, Jakub; Gmiat, Anna; Jaworska, Joanna; Kozłowska, Marta; Łysak-Radomska, Anna; Rodziewicz-Flis, Ewa; Żychowska, Małgorzata; Ziemann, Ewa

doi:10.1016/j.physbeh.2020.113235

Cited by 14 publications

(25 citation statements)

References 57 publications

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“…Plasma CTSB is upregulated by aerobic exercise training and associated with cognition in young adults ( 25 ). In the present study we show that CTSB is increased in late-middle-aged adults after 26 weeks of aerobic training, indicating that CTSB levels change after prolonged activity ( 25 , 54 , 55 ) whereas shorter term aerobic exercise protocols ( 56 , 57 ), and resistance training ( 58 , 59 ) show no change. The present findings in late-middle aged adults at risk for AD extend findings from healthy younger adults that CTSB levels were positively correlated with a hippocampus-dependent visual memory task after a four-month aerobic exercise intervention ( 25 ).…”

Section: Discussionmentioning

confidence: 44%

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

et al. 2021

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Increasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking. To begin to address this issue, we utilized blood samples of 23 asymptomatic late middle-aged adults, with familial and genetic risk for AD (mean age 65 years old, 50% female) who underwent 26 weeks of supervised treadmill training. Systemic biomarkers implicated in learning and memory, including the myokine Cathepsin B (CTSB), brain-derived neurotrophic factor (BDNF), and klotho, as well as metabolomics were evaluated. Here we show that aerobic exercise training increases plasma CTSB and that changes in CTSB, but not BDNF or klotho, correlate with cognitive performance. BDNF levels decreased with exercise training. Klotho levels were unchanged by training, but closely associated with change in VO2peak. Metabolomic analysis revealed increased levels of polyunsaturated free fatty acids (PUFAs), reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis, with exercise. Multiple metabolites (~30%) correlated with changes in BDNF, but not CSTB or klotho. The positive association between CTSB and cognition, and the modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function. Overall, our analyses indicate metabolic regulation of exercise-induced plasma BDNF changes and provide evidence that CTSB is a marker of cognitive changes in late middle-aged adults at risk for dementia.

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Section: Discussionmentioning

confidence: 44%

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

et al. 2021

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“…A recent study of adult sedentary women showed that after 5 weeks of high-intensity circuit training (HICT), the CTSB and BDNF concentrations in plasma were increased. Their quality of life and cognitive functions were improved [25]. These results suggest that plasma CTSB can be upregulated by aerobic exercise training, which may be associated with cognitive performance in young adults.…”

Section: Cathepsin B (Ctsb)mentioning

confidence: 69%

Effects of Physical Activity-Induced Myocytokines on Alzheimer's Disease

He¹

2022

JQHE

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This article aims to summarize the current research on the influence of physical activity-induced changes in myocytokine secreted by skeletal muscle cells on Alzheimer's disease (AD). Alzheimer's disease is the most common neurodegenerative disease leading to dementia. The limited clinical effect of current drug therapy, and there is no effective treatment strategy to treat, reverse or slow down the progression leading to an irreversible course. Physical activity (PA) is any physical exercise produced by skeletal muscles that requires energy consumption. Research shows that moderate physical activity is beneficial to health, and more evidence supports the beneficial effects of PA on neurodegenerative diseases such as AD, Mild cognitive impairment, and Dementia. This article reviewed the current research progress on the influence of changes in myocytokine expression induced by physical activity on AD, which would lay the foundation for further exploration of the mechanism of physical activity to improve cognition and prevent AD in the elderly

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“…All eight included studies were published between 2016–2022 and had been conducted in six countries (Canada: 2, Poland:1, Spain:1, Turkey:1, UK: 1, USA: 2). Six studies used experimental designs (Gaitán et al, 2021; Gourgouvelis et al, 2018; Micielska et al, 2021; Moon et al, 2016; Nicolini et al, 2019 Malcolm et al, 2022), one study had a cross-sectional design (De la Rosa et al, 2019), and one study had both cross-sectional and experimental sections (Gokce et al, 2021). The sample size ranged from 18 to 68 participants.…”

Section: Resultsmentioning

confidence: 99%

The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review

Gökçe

Gün

2023

Percept Mot Skills

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Exercise has been shown repeatedly to improve cognitive functions. Many investigators have reported that peripheral signal molecules play an important role in regulating exercise-induced cognitive improvement. In this review we aimed to evaluate and clarify the literature to date that has focused on the relationship between Cathepsin B, cognitive functions, and exercise. We conducted a systematic review of the following databases from their inception until 10 April 2022: Pubmed, Web of Science, Scopus, Cochrane Library, Physiotherapy Evidence Database. The search strategy was comprised of (“cathepsin b”) AND (exercise OR “physical activity”) AND (cognit*). We followed three different quality appraisal tools to ensure the quality of the included studies. Eight studies assessing the effects of exercise on peripheral Cathepsin B levels and cognitive outcomes were included. Half of these studies indicated that exercise increased peripheral Cathepsin B levels and improved cognitive function. Further carefully designed studies focusing on the effects of exercise on peripheral Cathepsin B levels and cognitive performance are needed to better comprehend the underlying mechanisms of these relationships.

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Habitually inactive physically – a proposed procedure of counteracting cognitive decline in women with diminished insulin sensitivity through a high-intensity circuit training program

Cited by 14 publications

References 57 publications

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Effects of Physical Activity-Induced Myocytokines on Alzheimer's Disease

The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review

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