The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review

Gökçe, Evrim; Gün, Neslişah

doi:10.1177/00315125231176980

Cited by 5 publications

(3 citation statements)

References 72 publications

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“…86,95 In humans, increases in cathepsin B after AT have been associated with improved cognitive function. 87,96 While more research is needed to understand how exercise training regulates cathepsin B levels and its impact on CSVD, preliminary findings suggest that cathepsin B has the potential to improve brain health.…”

Section: Exerkinesmentioning

confidence: 99%

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise

Dao,

Barha,

Zou

et al. 2024

Stroke

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Vascular contributions to cognitive impairment and dementia, specifically cerebral small vessel disease (CSVD), are the second most common cause of dementia. Currently, there are no specific pharmacological treatments for CSVD, and the use of conventional antidementia drugs is not recommended. Exercise has the potential to prevent and mitigate CSVD-related brain damage and improve cognitive function. Mechanistic pathways underlying the neurocognitive benefits of exercise include the control of vascular risk factors, improving endothelial function, and upregulating exerkines. Notably, the therapeutic efficacy of exercise may vary by exercise type (ie, aerobic versus resistance training) and biological sex; thus, studies designed specifically to examine these moderating factors within a CSVD context are needed. Furthermore, future research should prioritize resistance training interventions, given their tremendous therapeutic potential. Addressing these knowledge gaps will help us refine exercise recommendations to maximize their therapeutic impact in the prevention and mitigation of CSVD.

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Section: Exerkinesmentioning

confidence: 99%

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise

Dao,

Barha,

Zou

et al. 2024

Stroke

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“…We also detected some myofiber clusters exhibiting higher levels of cathepsin B (MFDEGEN in Fig. 2K and 2L), which were formerly associated with an exercise effect [24] or muscle degeneration [25]. However, these areas were scattered over the histological area without specific patterns (Fig.…”

Section: Identification Of Hybrid Myofiber Phenotypes Through Grid-ba...mentioning

confidence: 82%

High-Resolution Spatial Transcriptomic Atlas of Mouse Soleus Muscle: Unveiling Single Cell and Subcellular Heterogeneity in Health and Denervation

Hsu,

Ruiz,

Hwang

et al. 2024

Preprint

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Skeletal muscle is essential for both movement and metabolic processes, characterized by a complex and ordered structure. Despite its importance, a detailed spatial map of gene expression within muscle tissue has been challenging to achieve due to the limitations of existing technologies, which struggle to provide high-resolution views. In this study, we leverage the Seq-Scope technique, an innovative method that allows for the observation of the entire transcriptome at an unprecedented submicron spatial resolution. By applying this technique to the mouse soleus muscle, we analyze and compare the gene expression profiles in both healthy conditions and following denervation, a process that mimics aspects of muscle aging. Our approach reveals detailed characteristics of muscle fibers, other cell types present within the muscle, and specific subcellular structures such as the postsynaptic nuclei at neuromuscular junctions, hybrid muscle fibers, and areas of localized expression of genes responsive to muscle injury, along with their histological context. The findings of this research significantly enhance our understanding of the diversity within the muscle cell transcriptome and its variation in response to denervation, a key factor in the decline of muscle function with age. This breakthrough in spatial transcriptomics not only deepens our knowledge of muscle biology but also sets the stage for the development of new therapeutic strategies aimed at mitigating the effects of aging on muscle health, thereby offering a more comprehensive insight into the mechanisms of muscle maintenance and degeneration in the context of aging and disease.

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“…Cathepsin B, another myokine produced in the muscle, can also cross the BBB and has been shown to improve memory and cognition function [115]. It is also possible that this myokine may also contribute to the antidepressant effects of physical exercise.…”

Section: Physical Exercise Brain Function and Mddmentioning

confidence: 99%

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

Souza,

de Araujo Borba,

Castro de Jesus

et al. 2023

IJMS

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Major depressive disorder (MDD) has a high prevalence and is a major contributor to the global burden of disease. This psychiatric disorder results from a complex interaction between environmental and genetic factors. In recent years, the role of the gut microbiota in brain health has received particular attention, and compelling evidence has shown that patients suffering from depression have gut dysbiosis. Several studies have reported that gut dysbiosis-induced inflammation may cause and/or contribute to the development of depression through dysregulation of the gut–brain axis. Indeed, as a consequence of gut dysbiosis, neuroinflammatory alterations caused by microglial activation together with impairments in neuroplasticity may contribute to the development of depressive symptoms. The modulation of the gut microbiota has been recognized as a potential therapeutic strategy for the management of MMD. In this regard, physical exercise has been shown to positively change microbiota composition and diversity, and this can underlie, at least in part, its antidepressant effects. Given this, the present review will explore the relationship between physical exercise, gut microbiota and depression, with an emphasis on the potential of physical exercise as a non-invasive strategy for modulating the gut microbiota and, through this, regulating the gut–brain axis and alleviating MDD-related symptoms.

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The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review

Cited by 5 publications

References 72 publications

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise

High-Resolution Spatial Transcriptomic Atlas of Mouse Soleus Muscle: Unveiling Single Cell and Subcellular Heterogeneity in Health and Denervation

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

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