Habitual Alcohol Consumption and Metabolic Syndrome in Patients with Sleep Disordered Breathing

Abstract

To investigate the associations between amount of habitual alcohol consumption (HAC) and prevalence of metabolic syndrome (MetS), sleep, and sleep-disordered breathing (SDB). We enrolled 683 untreated SDB male patients (age: 54.4 ± 7.80 y, apnea-hypopnea index (AHI): 29.0 ± 21.53/h). HAC was assessed as the average number of drinks consumed per week during the past 12 months. Anthropometric and biochemical markers were used to diagnose MetS. Clinical data and MetS components were compared according to the reported amounts of HAC (no drinking, light drinking <13, heavy drinking ≥13 drinks/week). As reported, 78.9% of the participants (n = 539) were regular drinkers; 33.7% (n = 230) were habitually heavy drinkers (mean: 30.7 drinks/week), and 45.2% (n = 309) were light drinkers (5.1 drinks/week). The overall prevalence of MetS was 36.9% (n = 252) and was most common in heavy drinkers (40.5%). Compared to non-drinkers and light drinkers, heavy drinkers had the greatest body mass index (BMI) and waist circumference. Central obesity, hypertension, and hyperglycemia were most prevalent in heavy drinkers. Sleep quality and severity of SDB were the worst in heavy drinkers. After adjusting for age, AHI, and BMI, heavy drinkers had a 1.71 times greater risk of MetS when compared with non-drinkers, and light and heavy drinkers had a 2.06 and 2.11 times higher risk of severe SDB than non-drinkers. HAC may increase the prevalence of MetS and deteriorate sleep in relation to amount of alcohol intake. Even light drinkers had more than twice higher risk of severe SDB than non-drinkers.

Association Between Amyloid Accumulation and Sleep in Patients With Idiopathic REM Sleep Behavior Disorder

“…Registration survey contained questions about alcohol, caffeine consumption, habitual sleep time, habitual sleep latency, underlying disease, and onset of RBD symptom. In particular, alcohol consumption was assessed using questions about average weekly consumption during the past 12 months ( 30 ). All participants fulfilled sleep diary more than 2 weeks before enrollment.…”

Ambulatory blood pressure in relation to oxygen desaturation index as simultaneously assessed by nighttime finger pulse oximetry at home

“…ODI was assessed by overnight finger pulse oximetry in 2342 participants on the day of ambulatory BP monitoring, and calculated as the number of desaturation episodes per sleeping hour. Both BP and pulse rate increased significantly (P ≤ .006) from normal (< 5 events/h) to mildly (5)(6)(7)(8)(9)(10)(11)(12)(13)(14), moderately (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and severely (≥ 30 events/h) elevated ODI. The association for BP was substantially attenuated by accounting for pulse rate (partial r² from .003-.012 to .002-.006).…”

“…The possible reasons underpinning these sex-related discrepancies could be that in our study, men, compared with women, had significantly greater body mass index (+1.3 kg/m²) and it is well known that Chinese men have a much higher proportion of alcohol intake than women. 28 Both obesity 29 and alcohol intake 30 are well defined risk factors for OSAHS and hypertension.…”

Cultivating Lifestyle Transformations in Obstructive Sleep Apnea

“…Heavy drinkers had the most severe SDB (the highest AHI [32.2/hour] and the lowest oxygen desaturation [81.1%]) and the most fragmented sleep structures (the highest arousal indices [34.5/hour] and N1 sleep proportion [27.3%]) in comparison to the non-drinkers or light drinkers. It was concluded that despite fair amounts, people with HAC and SDB might have a two-fold more significant risk of developing severe respiratory-related disturbances during sleep [ 44 ]. Simou et al followed a systematic review and meta-analysis of the link between alcohol consumption and OSA in adults.…”