Habitual Abortion and Stillbirth Syndrome

Core outcomes for reporting women's health

“…There are others, like Lesley Regan in the UK, who also are well known in this field , if the reader wishes to obtain added information. In all there are over 7300 publications on PubMed listed under the search term “recurrent miscarriage” (or habitual abortion), from the first one in 1937 , but this pertains to more than early recurrent miscarriage, – which Vlaanderen and Christiansen debate, – to include cervical incompetence, stillbirths, conizations and more. Of these articles 57 are in AOGS, with a recent one of relevance to the necessity of establishing core outcome measures .…”

Similarity of Symptomatology of Premenstrual Syndrome and Toxaemia of Pregnancy and Their Response to Progesterone

“…They describe their results as encouraging. Clinical trials of progesterone were then undertaken by Marsden (1937), Young (1937), Paterson (1938-9), McMann (1938, and by Bennett, who in 1939, after reviewing all trials, concluded: "It is unlikely that progesterone treatment will ever find a permanent place in routine treatment of toxaemia. "…”

Vitamin E in Habitual Abortion

“…Watson in his paper has pointed out that vitamin E bears more resemblance as regards clinical features, physiological properties, and clinical significance to the lulteal hormone (progestin) than to other hormones. This is a point of interest, because other observers (Johnson, Krohn, and Kane) have achieved satisfactory results in the treatment of habitual abortion with the use of the luteal hormone, and as James Young (1937) has pointed out it may be that the work of the vitamin is completed when the placenta is fully developed. Until recently it was the accepted view that the action of the corpus luteum ceased about the middle of pregnancy, and this statement was substantiated by the fact that women did not necessarily abort if the ovar-ies were removed after the twelfth week.…”