Habenula lesions alter synaptic plasticity within the fimbria–accumbens pathway in the rat

Lecourtier, Lucas; Deschaux, Olivier; Arnaud, C.; Chessel, Aline; Kelly, Peter H.; García, René

doi:10.1016/j.neuroscience.2006.04.018

Cited by 24 publications

(18 citation statements)

References 45 publications

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“…One possible site for such hypersensitivity is the nucleus accumbens, a DA terminal site critical for psychostimulant locomotion. Indeed, it has been shown that lesions of the habenula alter synaptic plasticity within the fimbria-accumbens pathway, leading to increased long-term depression in nucleus accumbens (Lecourtier et al, 2006). Depression of synaptic strength in this nucleus is a common action of psychostimulants (Nicola et al, 1996) and is associated with a hypersensitive (sensitized) locomotor response following repeated exposure to these drugs (Beurrier and Malenka, 2002;Thomas et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Lesions of the lateral habenula dissociate the reward-enhancing and locomotor-stimulant effects of amphetamine

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Lesions of the lateral habenula dissociate the reward-enhancing and locomotor-stimulant effects of amphetamine

et al. 2012

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“…Scale bars a, e, l 200 lm, b, c 300 lm, d 400 lm, f-k, m, n 30 lm plexus is mainly involved in the production of cerebrospinal fluid (CSF) and in a variety of neurological disorders (Wolburg and Paulus 2009;Wrede et al 2009). Recently, habenula has attracted a great deal of attention for its prominent role in the regulation of dopamine and serotonin systems in terms of depression, anxiety, sleep mode, and extrapyramidal motor functions (Lecourtier et al 2006;Hikosaka 2010). As depression is associated with cell death (Arantes-Goncalves and Coelho 2006;McKernan et al 2009) and ProTa is a potent neuroprotective protein (Ueda et al 2007), the role of ProTa in the habenula may be an intriguing subject in the phenotypic analysis of Fig.…”

Section: Discussionmentioning

confidence: 99%

Regional Distribution and Cell Type-Specific Subcellular Localization of Prothymosin Alpha in Brain

Halder

Ueda

2011

Cell Mol Neurobiol

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Prothymosin alpha (ProTα) is an acidic nuclear protein implicated in several cellular functions including cell survival. ProTα is found in the central nervous system, but the regional and cell type-specific expression patterns are not known. In this study, our immunohistochemical analysis demonstrated that ProTα is expressed ubiquitously throughout adult brain with difference in the intensity of region-specific protein reactivity. Interestingly, the highest ProTα signals were observed in the brain regions relevant to neurogenesis, such as sub-ventricular zone, granular cell layer of dentate gyrus, as well as granule cell layer of olfactory bulb. Strong immunoreactivity was also found in habenula, ependymal cells lining the dorsal third and fourth ventricle, and in neurons in the Purkinje cell layer of cerebellum. We showed that ProTα was strictly localized in the nuclei of neurons, while it was found in the cytosolic space of astroglial and microglial processes and cell body in the adult brain. To clarify the phenomenon underlying cytosolic localization of ProTα in non-neuronal cells, ZVAD-fmk, a caspase-3 inhibitor, was delivered intracerebroventricularly in the brain. At the follow-up 24 h after ZVAD-fmk injection, we found that nuclear intensity of ProTα was significantly increased in astrocytes, whereas the ProTα expression was not affected in microglia. The present study would contribute toward better understanding of physiological and pathophysiological roles of ProTα in the brain.

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“…an immediate occurrence of an impulsive mode of behaviour, represented by a large increase in premature responding, and a late-occurring decline of accuracy. Finally, habenula lesions depress synaptic plasticity in the hippocampus-nucleus accumbens pathway (Lecourtier et al, 2006), involved in many cognitive processes.…”

Section: Cognitive Functions Of the Lhbmentioning

confidence: 99%

Habenula: Crossroad between the Basal Ganglia and the Limbic System

Hikosaka¹,

Sesack²,

Lecourtier³

et al. 2008

J. Neurosci.

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378

267

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There is a growing awareness that emotion, motivation, and reward values are important determinants of our behavior. The habenula is uniquely positioned both anatomically and functionally to participate in the circuit mediating some forms of emotive decision making. In the last few years there has been a surge of interest in this structure, especially the lateral habenula (LHb). The new studies suggest that the LHb plays a pivotal role in controlling motor and cognitive behaviors by influencing the activity of dopamine and serotonin neurons. Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and druginduced psychosis.

show abstract

Habenula lesions alter synaptic plasticity within the fimbria–accumbens pathway in the rat

Cited by 24 publications

References 45 publications

Lesions of the lateral habenula dissociate the reward-enhancing and locomotor-stimulant effects of amphetamine

Lesions of the lateral habenula dissociate the reward-enhancing and locomotor-stimulant effects of amphetamine

Regional Distribution and Cell Type-Specific Subcellular Localization of Prothymosin Alpha in Brain

Habenula: Crossroad between the Basal Ganglia and the Limbic System

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