HA metabolism in skin homeostasis and inflammatory disease

Kavasi, Rafaela‐Maria; Berdiaki, Aikaterini; Spyridaki, Ioanna; Corsini, Emanuela; Tsatsakis, Aristidis; Tzanakakis, George N.; Nikitovic, Dragana

doi:10.1016/j.fct.2017.01.012

Cited by 69 publications

(58 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chow et al () revealed a potent role of HA in EMT of epithelial‐phenotype cancer cells by up‐regulating HAS3. HAS3 is one of the three mammalian HA synthases that is usually overexpressed in malignancies (Adamia et al, ) or inflammation (Kavasi et al, ). Not only was the epithelial‐like morphology of HAS3‐overexpressing cells transformed into a mesenchymal‐like one, but also, E‐cadherin was decreased, while their vimentin expression was enhanced (Chow et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, oligosaccharides that result from HA degradation and low‐molecular‐weight HA (LMWHA) are capable of initiating angiogenesis and inflammation. On the other hand, high‐molecular‐weight HA (HMWHA) (1000–2000 kDa), which facilitates homeostasis, is present in intact tissues and is antiangiogenic as well as immunosuppressive (West et al, ; Jiang et al, ; Kavasi et al, ).…”

Section: Extracellular Matrix Organizationmentioning

confidence: 99%

See 1 more Smart Citation

Role of the extracellular matrix in cancer‐associated epithelial to mesenchymal transition phenomenon

Tzanakakis

Kavasi

Voudouri

et al. 2017

Developmental Dynamics

Self Cite

View full text Add to dashboard Cite

The epithelial to mesenchymal transition (EMT) program is a crucial component in the processes of morphogenesis and embryonic development. The transition of epithelial to mesenchymal phenotype is associated with numerous structural and functional changes, including loss of cell polarity and tight cell-cell junctions, the acquisition of invasive abilities, and the expression of mesenchymal proteins. The switch between the two phenotypes is involved in human pathology and is crucial for cancer progression. Extracellular matrices (ECMs) are multi-component networks that surround cells in tissues. These networks are obligatory for cell survival, growth, and differentiation as well as tissue organization. Indeed, the ECM suprastructure, in addition to its supportive role, can process and deliver a plethora of signals to cells, which ultimately regulate their behavior. Importantly, the ECM derived signals are critically involved in the process of EMT during tumorigenesis. This review discusses the multilayer interaction between the ECM and the EMT process, focusing on contributions of discrete mediators, a strategy that may identify novel potential target molecules. Developmental Dynamics 247:368-381, 2018. V C 2017 Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Extracellular Matrix Organizationmentioning

confidence: 99%

Role of the extracellular matrix in cancer‐associated epithelial to mesenchymal transition phenomenon

Tzanakakis

Kavasi

Voudouri

et al. 2017

Developmental Dynamics

Self Cite

View full text Add to dashboard Cite

show abstract

“…The dermal extracellular matrix (ECM) plays a major role in regulating skin functions and status . Among ECM components, hyaluronic acid (HA), a high‐molecular‐weight polysaccharide mainly synthesized by dermal fibroblasts, provides hydration to healthy skin and promotes tissue organization and repair .…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective, anti‐inflammatory, and antioxidant properties of high‐molecular‐weight hyaluronan enriched with red orange extract in human fibroblasts exposed to ultra violet light B irradiation

Albanesi

Bertorelli

Bandiera

et al. 2019

Biotech and App Biochem

View full text Add to dashboard Cite

Ultraviolet (UV) light exposure is the primary factor responsible for skin photoaging, affecting all the skin layers, mainly through the production of reactive oxygen species (ROS), activation of inflammatory responses, and apoptosis. In keeping with this evidence, exogenous supplementation with dietary antioxidants has been shown to provide photoprotective benefits. Moreover, oral administration of hyaluronic acid (HA) has been proved to reduce the signs of aged skin, such as wrinkles, and increase hydration and elasticity. The combination of different biologically active substances in order to slow down the onset of skin aging could represent a promising preventive strategy against photoaging. In the present study, we investigated the effects of a dietary supplement (IALUTEC R RED), consisting of high-molecular-weight HA (HMW-HA) combined with red orange extract (ROC-Red Orange Complex R ), in human fibroblasts exposed to ultra violet light B-induced oxidative stress. Our study suggests that, in fibroblasts exposed to UVB light, IALUTEC R RED is active in decreasing both the inflammatory response and the generation of ROS, two events that are involved in skin photoaging.

show abstract

“…Deri ülserleri, atopik dermatit, kuruluk, kızarıklık gibi daha birçok deri hastalıklarının tedavisinde oldukça etkili bulunmaktadır. 70 Sitotoksisitesi açısından incelendiğinde HA'nın, oldukça biyouyumlu olduğu ve sitotoksik etkilerinin olmadığı gözlenmiştir. 72 Türler arası yapısal benzerliğinin olması ve kan bileşenleriyle zayıf etkileşimi nedeni ile antijenik etkiler göstermemektedir ve immünojenik değildir.…”

Section: Hi̇yalüroni̇k Asi̇tunclassified