H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight

Hewage, Asanka Sudeshini; Jayanthiny, P.; Tennekoon, Kamani Hemamala; Kumarasiri, J. M.; Wijesundere, Anula; Karunanayake, E.H.

doi:10.1007/s12020-014-0402-z

Cited by 7 publications

(8 citation statements)

References 12 publications

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“…26 Another research shown that maternal H19 rs217727 TT genotype was associated with a higher birth weight. 27 A population-based case–control study comprising 177 bladder cancer patients and 204 controls reported that rs2839698 TC genotype was statistical significantly associated with decreased risk of bladder cancer compared with TT carriers (OR = 0.60; 95% CI = 0.36–0.99). And a borderline significantly decreased risk of bladder cancer was found for rs217727 T allele carriers compared with C allele carriers (OR = 0.74; 95% CI = 0.51–1.06).…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population

et al. 2016

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H19, a maternally expressed imprinted gene transcribing a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression. However, the association between the H19 polymorphisms and breast cancer (BC) susceptibility has remained elusive. The aim of this study was to evaluate the associations between 2 H19 haplotype tagging SNPs (rs3741219 T>C, rs217727 C>T) and the risk of breast cancer.Our study comprised 464 BC patients and 467 cancer-free controls in China. rs3741219 and rs217727 were genotyped with polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) and created restriction site PCR (CRS-RFLP) assays, respectively. False-positive report probability (FPRP) was calculated to test the false-positive association.On performing univariate analysis, no significant association between H19 polymorphisms (rs3741219 and rs217727) and BC was observed. However, in further stratified analyses, CT+TT genotypes of rs217727 had a significantly lower risk of breast cancer among women with number of pregnancy >2 (OR = 0.79; 95% CI = 0.55–0.97). CT genotype of rs217727 was associated with ER positivity (OR = 2.19; 95 % CI = 1.07–4.45) and HER-2 positivity (OR = 1.34; 95 % CI = 1.05–2.12). It was proved that our results were less likely to be false positives according to false-positive report probability calculation.Our findings extend available data on the association of H19 polymorphisms and BC susceptibility. Further validation in large population or cohort studies is needed.

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Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population

et al. 2016

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“…Gao et al also demonstrated that the nucleotide change in rs217727 C to T is associated with an increased risk of coronary artery disease, while the rs2067051 G to A is associated with a reduction in the risk of coronary artery disease. Hewage et al, in a case‐control investigation, assessed 177 patients with bladder cancer and 204 controls and reported that rs2839698 T>C was associated with a reduction in the risk of bladder cancer. In addition, findings showed a significant reduction in the bladder cancer risk in carriers of the T rs217727 allele compared with carrier C allele.…”

Section: Discussionmentioning

confidence: 99%

Association of the study between LncRNA‐H19 gene polymorphisms with the risk of breast cancer

Abdollahzadeh

Ghorbian

2018

Clinical Laboratory Analysis

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Background The H19 is a maternally expressed imprinted gene transcribing a long noncoding RNA (lncRNA), which has previously been reported to be involved in tumorigenesis and cancer progression. The aim of this study was to evaluate the associations between two lncRNA‐H19 (rs3741219 T>C and rs217727 C>T) gene polymorphisms with the risk of breast cancer (BC). Methods In a case‐control investigation, we evaluated 150 BC patients and 100 cancer‐free subjects in East Azerbaijan Province of Iran. To assess two gene polymorphisms, the polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method was used. Results The genotype frequencies of two lncRNA‐H19 (rs217727 C>T and rs3741219 T>C) gene polymorphisms TT + TC/CC and CC + CT/TT have not shown a statistically significant association with the risk of BC (P = 0.065; OR = 0.967; 95% CI, 0.938‐0.996) and (P = 0.510; OR = 1.583; 95% CI, 0.399‐6.726), respectively. In addition, our findings revealed a significant differences in allele frequencies in lncRNA‐H19 rs217727 C>T polymorphism between groups (P = 0.033; OR = 1.985; 95% CI, 1.048‐3.761). Conclusion Our findings suggested that rs217727 C>T polymorphism may be involved in the pathogenesis of BC, whereas rs3741219 T>C variation may not be involved in the genetic background of BC in Iranian.

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“…Gao et al argued that rs217727C to T variant was associated with increased coronary artery disease risk (CAD) (CT + TT vs CC: OR = 1.49; 95% CI = 1.21‐1.83), whereas the rs2067051 G to A variant was associated with reduced CAD risk (GA + AA vs GG: OR = 0.77; 95% CI = 0.62‐0.95). Another research showed that maternal TT genotype of H19‐rs217727 was associated with a higher birth weight …”

Section: Discussionmentioning

confidence: 99%

“…As previous genomics studies have demonstrated that single nucleotide polymorphisms (SNPs) in several genes were associated with the risk of PE; recently, studies on the effects of SNPs have extended to functional lncRNAs . Evidence suggests that H19 genetic variants play important roles in the development of some diseases such as cancers (Gastric cancer and bladder cancer), Coronary artery disease, and higher birth weight . However, there is no published report on the association between H19 polymorphisms and PE.…”

Section: Introductionmentioning

confidence: 99%

The long non‐coding RNA H19 rs217727 polymorphism is associated with PE susceptibility

Harati‐Sadegh

Kohan

Teimoori

et al. 2018

J of Cellular Biochemistry

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H19 is an imprinted gene transcribing a long noncoding RNA which was previously reported to be involved in some diseases. However, the association between the H19 polymorphisms and Pre-eclampsia (PE) susceptibility has remained elusive. This study aimed to evaluate the association between three H19 haplotype SNPs (rs3741219, rs217727, and rs2107425) and the risk of PE. The present case control study consisted of 193 PE women and 201 controls. The H19 rs3741219 and rs217727 polymorphisms were genotyped with PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) and the H19 rs2107425 polymorphism with ARMS-PCR (Amplification refractory mutation system) methods. The frequency of alleles and genotypes of H19 rs3741219 and rs2107425 polymorphisms did not differ between PE women and controls. The frequency of the H19 rs217727T allele was significantly higher in PE women (P < 0.0001). The H19 rs217727 polymorphism was associated with higher PE susceptibility in the Co-dominant (OR = 12.1, 95% CI = 5.7-24.5, P < 0.0001 for CT genotype and OR = 29.7, 95% CI = 12.9-68.1, P < 0.0001 for TT genotype), Dominant (OR = 15.1, 95% CI = 7.5-30.3, P = P < 0.0001), Recessive (OR = 4.5, 95% CI = 2.6-7.9, P = < 0.0001), and Over-dominant (OR = 2.1, 95% CI = 1.4-3.1, P = 0.0006) models. Furthermore, the CCC, TCT, TCC, and CCT haplotypes of H19 rs3741219, rs217727, rs2107425 were associated with lower risk of PE; however, the CTC, TTC, and TTT haplotypes were associated with higher risk of PE. In conclusion, the present study found the relationship between H19 rs217727 but not rs3741219 and rs2107425 polymorphisms and PE susceptibility. In addition, the CTC, TTC, and TTT haplotypes were associated with the higher risk of PE.

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H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight

Cited by 7 publications

References 12 publications

Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population

Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population

Association of the study between LncRNA‐H19 gene polymorphisms with the risk of breast cancer

The long non‐coding RNA H19 rs217727 polymorphism is associated with PE susceptibility

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